Parathyroid carcinoma

Otolaryngologic Clinics of North America

Volumn 43, Issue 2, 2010, Pages 441-453

  Dudney, W Cross ^a   Bodenner, Donald ^a,b,c   Stack, Brendan C ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Parathyroid; Parathyroid cancer; Parathyroid carcinoma; Parathyroid hormone

Indexed keywords

ALKALINE PHOSPHATASE; CARCINOEMBRYONIC ANTIGEN; PARATHYROID HORMONE; VITAMIN D;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; BACKACHE; BACTEREMIA; CALCIUM BLOOD LEVEL; CASE REPORT; CLINICAL FEATURE; DIALYSIS; DISEASE COURSE; DISEASE DURATION; DYSPNEA; FRACTURE; GOITER; HEMITHYROIDECTOMY; HISTOPATHOLOGY; HUMAN; HYPERCALCEMIA; KYPHOSCOLIOSIS; MALE; MEDIASTINUM MASS; NECK DISSECTION; NECK TUMOR; OSTEOPOROSIS; PARATHYROID CARCINOMA; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROIDECTOMY; PREOPERATIVE PERIOD; PREVALENCE; RESPIRATORY FAILURE; REVIEW; SCAPULA FRACTURE; THORACOTOMY; THYROID SURGERY; TUMOR VOLUME; ULTRASOUND; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

BONE NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; HUMANS; HYPERCALCEMIA; MALE; MEDIASTINAL NEOPLASMS; MIDDLE AGED; NECK DISSECTION; PARATHYROID GLANDS; PARATHYROID HORMONE; PARATHYROID NEOPLASMS; PARATHYROIDECTOMY; RIBS; THORACOTOMY; THYROIDECTOMY; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY;

EID: 77953267115     PISSN: 00306665     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otc.2010.01.011     Document Type: Review

References (69)

1. de Quervain F. Parastruma maligna aberrata [Malignant aberrant parathyroid]. Deusche Zeitschr Chir 1904, 100:334-352. [in German].
2. Sainton P., Millot J. Malegne d'un adenoma parathyroidiene eosinophile [Malignant eosinophilic parathyroid]. Au cours d'une de Recklinghausen. Ann Anal Pathol 1933, 10:813. [in French].
3. Holmes E., Morton D., Ketcham A. Parathyroid carcinoma: a collective review. Ann Surg 1969, 169:631-640.
4. Fujimoto Y., Obara T. How to recognize and treat parathyroid carcinoma. Surg Clin North Am 1987, 67:343-357.
5. Shane E. Parathyroid carcinoma. J Clin Endocrinol Metab 2001, 86:485-493.
6. Iihara M., Okamoto T., Suzuki R., et al. Functional parathyroid carcinoma: long-term treatment outcome and risk factor analysis. Surgery 2007, 142:936-943.
7. Obara T., Okamoto T., Ito Y., et al. Surgical and medical management of patients with pulmonary metastasis from parathyroid carcinoma. Surgery 1993, 114:1040-1049.
8. Giesler G., Beech D. Nonfunctional parathyroid carcinoma. J Natl Med Assoc 2001, 93:251-255.
9. Okamoto T., Iihara M., Obara T., et al. Parathyroid carcinoma: diagnosis, etiology, treatment. World J Surg 2009, Available at:, Accessed July 12, 2009. http://www.springerlink.com/content/g3h320187l3ru638/.
10. Shane E., Bilezikian J. Parathyroid carcinoma: a review of 62 patients. Endocr Rev 1982, 3:218-226.
11. Sandelin K., Auer G., Bondeson L., et al. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg 1992, 16:724-731.
12. Fujimoto Y., Obara T., Ito Y., et al. Surgical treatment of ten cases of parathyroid carcinoma: importance of an initial en block resection. World J Surg 1984, 8:392-400.
13. Favia G., Lumachi F., Polistina F., et al. Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg 1998, 22:1225-1230.
14. Dotzenrath C., Goretzki P.E., Sarbia M., et al. Parathyroid carcinoma: problems in diagnosis and the need for radical surgery even in recurrent disease. Eur J Surg Oncol 2001, 27:383-389.
15. Hakaim A.G., Esselstyn C.B. Parathyroid carcinoma: 50-year experience at The Cleveland Clinic Foundation. Cleve Clin J Med 1993, 60:331-335.
16. Obara T., Fujimoto Y. Diagnosis and treatment of patients with parathyroid carcinoma: an update and review. World J Surg 1991, 15:738-744.
17. Hundahl S., Fleming I., Fremgen A., et al. Two hundred eighty-six cases of parathyroid carcinoma treated in the US between 1985-1995, a national cancer data base report. Cancer 1999, 86:538-544.
18. Jenkins P., Satta M., Simmgen M., et al. Metastatic parathyroid carcinoma in the MEN2A syndrome. Clin Endocrinol 1997, 41:747-751.
19. Hamill J., Maoate K., Beasley S., et al. Familial parathyroid carcinoma in a child. J Paediatr Child Health 2002, 38:314-317.
20. Dionisi S., Minisola S., Pepe J., et al. Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: presentation as hypercalcemic crisis. Mayo Clin Proc 2002, 77:866-869.
21. Weinstein L., Simonds W. HRPT2, a marker of parathyroid cancer. N Engl J Med 2003, 349:1691-1692.
22. Cordeiro A., Montenegro F., Kulcsar M., et al. Parathyroid carcinoma. Am J Surg 1998, 175:52-55.
23. Levin K., Galante M., Clark O. Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia. Surgery 1987, 101:647-660.
24. Wynne A., Heerden J., Carney A., et al. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine 1992, 71:197-205.
25. Chen Q., Kaji H., Nomura R., et al. Trial to predict malignancy of affected parathyroid glands in primary hyperparathyroidism. Endocr J 2003, 50:527-534.
26. Silverberg S., Shane E., Jacobs J., et al. Nephrolithiasis and bone involvement in primary hyperparathyroidism. Am J Med 1990, 89:327-334.
27. Busaidy N.L., Jimenez C., Habra M.A., et al. Parathyroid carcinoma: a 22-year experience. Head Neck 2004, 26:716-726.
28. Chon K., Siverman M., Corrado J., et al. Parathyroid carcinoma: the Lahey Clinic experience. Surgery 1985, 98:1095-1100.
29. Mallette L.E., Bilezikian J.P., Ketcham A.S., et al. Parathyroid carcinoma in familial hyperparathyroidism. Am J Med 1974, 57:642-648.
30. Flye M.W., Brennan M.F. Surgical resection of metastatic parathyroid carcinoma. Ann Surg 1981, 193:425-435.
31. Snell S., Gaar E., Stevens S., et al. Parathyroid cancer, a continued diagnostic and therapeutic dilemma: report of four cases and review of the literature. Am Surg 2003, 69:711-718.
32. Schoretsanitis G., Daskalakis M., Melissas J., et al. Parathyroid carcinoma: clinical presentation and management. Am J Otol 2009, 30:277-280.
33. Clayman G.L., Gonzalez H.E., El-Naggar A., et al. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer 2004, 100:900-905.
34. Schantz A., Castleman B. Parathyroid carcinoma: a study of 70 cases. Cancer 1973, 31:600-605.
35. McKeown P., McGarity W., Sewell C. Carcinoma of the parathyroid gland: is it over diagnosed? A report of three cases. Am J Surg 1984, 147:292-297.
36. Stojadinovic A., Hoos A., Nissan A., et al. Parathyroid neoplasms: clinical, histopathological, and tissue microarray-based molecular analysis. Hum Pathol 2003, 34:54-64.
37. Obara T., Fujimato Y., Hivayama A., et al. Flow cytometric DNA analysis of parathyroid tumors with special reference to its diagnostic and prognostic value in parathyroid carcinoma. Cancer 1990, 65:1789-1793.
38. Abbona G., Papotti M., Gasparri G., et al. Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining. Hum Pathol 1995, 26:135-138.
39. Cetani F., Pardi E., Viacava P., et al. A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clin Endocrinol 2004, 60:99.
40. Westin G., Bjorklund P., Akerstrom G. Molecular genetics of parathyroid disease. World J Surg 2009, Available at:, Accessed July 12, 2009. http://www.springerlink.com/content/a2351831t228j77k/.
41. Tan M.H., Morrison C., Wang P., et al. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clin Cancer Res 2004, 10:6629-6637.
42. Rogers S.E. Perrier ND Parathyroid carcinoma. Curr Opin Oncol 2006, 18:16-22.
43. Rawat N., Khetan N., Williams D.W., et al. Parathyroid carcinoma. Br J Surg 2005, 92:1345-1353.
44. Mittendorf E.A., McHenry C.R. Parathyroid carcinoma. J Surg Oncol 2005, 89:136-142.
45. Valimaki S., Forsberg L., Farnebo L.O., et al. Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas. Int J Oncol 2002, 21:727-735.
46. Howell V.M., Haven C.J., Kahnoski K., et al. HRPT2 mutations are associated with malignancy in sporadic parathyroid tumors. J Med Genet 2003, 40:657-663.
47. Gill A.J., Clarkson A., Gimm O., et al. Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. Am J Surg Pathol 2006, 30:1140-1149.
48. Shattuck T., Valimaki S., Obara T., et al. Somatic and germline mutations of PRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med 2003, 349:1722-1729.
49. Cetani F., Ambrogini E., Viacava P., et al. Should parafibromin staining replace HRPT2 gene analysis as an additional tool for histological diagnosis of parathyroid carcinoma?. Eur J Endocrinol 2007, 156:547-554.
50. Haven C.J., van Puijenbroek M., Tan M.H., et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin embedded (sporadic) parathyroid carcinomas. Clin Endocrinol (Oxf) 2007, 67:370-376.
51. Hewitt K.M., Sharma P.K., Samowitz W., et al. Aberrant methylation of the HRPT2 gene in parathyroid carcinoma. Ann Otol Rhinol Laryngol 2007, 116:928-933.
52. Juhlin C.C., Haglund F., Villablanca A., et al. Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-b in parathyroid carcinomas. Int J Oncol 2009, 34:481-492.
53. DeLellis R.A. Parathyroid carcinoma: an overview. Adv Anat Pathol 2005, 12:53-61.
54. Hunt J.L., Carty S.E., Yim I.H., et al. Allelic loss in parathyroid neoplasia can help characterize malignancy. Am J Surg Pathol 2005, 29:1049-1055.
55. Kebebew E., Arici C., Duh Q., et al. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg 2001, 136:878-885.
56. Hara H., Igarahi A., Yano Y., et al. Ultrasonographic features of parathyroid carcinoma. Endocr J 2001, 48:213-217.
57. Weber A., Randolph G., Aksoy F. The thyroid and parathyroid glands: CT and MR imaging and correlation with pathology and clinic. Radiol Clin North Am 2000, 38:1105-1129.
58. Redman C., Bodenner D., Stack B. Role of vitamin D deficiency in continued hyperparathyroidism following parathyroidectomy. Head Neck 2009, Available at:, Accessed July 27, 2009. http://www3.interscience.wiley.com/journal/122296749/abstract?CRETRY=1&SRETRY=0.
59. Untch B.R., Barfield M.E., Dar M. Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. Surgery 2007, 142:1022-1026.
60. Kirkby-Bott J., Lewis P., Harmer C.L., et al. One stage treatment of parathyroid cancer. Eur J Surg Oncol 2005, 31:78-83.
61. Chow E., Tsang R., Breierley J., et al. Parathyroid carcinoma-the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys 1998, 41:569-572.
62. Muson N., Foote R., Northcutt R., et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy?. Cancer 2003, 98:2378-2384.
63. Calandra D., Chejfec G., Foy B., et al. Parathyroid carcinoma: biochemical and pathologic response to DTIC. Surgery 1984, 96:1132-1137.
64. Bukowski R., Sheller L., Cunningham J., et al. Successful combination chemotherapy for metastatic parathyroid carcinoma. Arch Intern Med 1984, 144:399-400.
65. Newrick P., Braafvedt G., Webd A., et al. Prolonged remission of hypercalcemia due to parathyroid carcinoma with pamidronate. Postgrad Med J 1994, 70:231.
66. Singer F., Neer R., Murray T., et al. Mithramycin treatment of intractable hypercalcemia due to parathyroid carcinoma. N Engl J Med 1970, 283:634-636.
67. Schott M., Feldkamp J., Schattenberg D., et al. Induction of cellular immunity in parathyroid carcinoma treated with tumor lysate-pulsed dendritic cells. Eur J Endocrinol 2000, 142:300-306.
68. Bradwell A.R., Harvey T.C. Control of hypercalcemia of parathyroid carcinoma by immunisation. Lancet 1999, 353:370-373.
69. Betea D., Bradwell A.R., Harvey T.C., et al. Hormonal and biochemical normalization and tumor shrinkage induced by antiparathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma. J Clin Endocrinol Metab 2004, 89:3413-3420.