Effects of AG490 on lens epithelial cell death induced by H 2O2

Japanese Journal of Ophthalmology

Volumn 54, Issue 2, 2010, Pages 151-155

  Kim, Ungsoo Samuel ^a   Nam, Sang Min ^b   Jung, Sun Ah ^a   Kim, Sung Joo ^a   Lee, Joon H ^a  

^a Konyang University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

AG490; Cataract; H2O2; Lens epithelial cell

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; HYDROGEN PEROXIDE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT3 PROTEIN; TYROSINE;

ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LENS EPITHELIUM; MICROSCOPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANNEXIN A5; BLOTTING, WESTERN; BUTADIENES; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; JANUS KINASES; LENS, CRYSTALLINE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRILES; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; STAT3 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 77953261983     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10384-009-0772-6     Document Type: Article

References (15)

1. Li WC, Kuszak JR, Dunn K, et al. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol 1995;130: 169-181.
2. Lee EH, Wan XH, Song J, et al. Lens epithelial cell death and reduction of anti-apoptotic protein Bcl-2 in human anterior polar cataracts. Mol Vis 2002;8:235-240.
3. Long AC, Colitz CM, Bomser JA. Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death. Exp Biol Med (Maywood) 2004;229:1072-1080.
4. Darnell JE Jr. STATs and gene regulation. Science 1997;277: 1630-1635.
5. Chin YE, Kitagawa M, Kuida K, Flavell RA, Fu XY. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol 1997;17:5328-5337.
6. Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 1996;272:719-722.
7. Wagner BJ, Hayes TE, Hoban CJ, Cochran BH. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J 1990;9:4477-4484.
8. Tacchini L, Fusar-Poli D, Bernelli-Zazzera A. Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochem Pharmacol 2002;63:139-148.
9. Gorina R, Petegnief V, Chamorro A, Planas AM. AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinfl ammatory cytokines: Involvement of the JAK2/STAT pathway. J Neurochem 2005;92:505-518.
10. Schallenberg M, Charalambous P, Thanos S. GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death. Exp Eye Res 2009;89:665-677.
11. Andley UP, Rhim JS, Chylack LT Jr, Fleming TP. Propagation and immortalization of human lens epithelial cells in culture. Invest Ophthalmol Vis Sci 1994;35:3094-3102.
12. Banes-Berceli AK, Ogobi S, Tawfik A, et al. Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species. Vascul Pharmacol 2005; 43:310-319.
13. Favata MF, Horiuchi KY, Manos EJ, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998;273:18623-18632.
14. Kopantzev Y, Heller M, Swaminathan N, Rudikoff S. IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells. Oncogene 2002;21:6791-6800.
15. Gardner AM, Xu FH, Fady C, et al. Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radic Biol Med 1997;22:73-83.