Management of functional abdominal pain and irritable bowel syndrome in children and adolescents

Expert Review of Gastroenterology and Hepatology

Volumn 4, Issue 3, 2010, Pages 293-304

  Chiou, Eric ^a   Nurko, Samuel ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Children; Cognitive behavioral therapy; Dietary therapy; Functional abdominal pain; Irritable bowel syndrome; Pharmacotherapy; Psychosocial intervention; Recurrent abdominal pain

Indexed keywords

ALOSETRON; AMITRIPTYLINE; CIMETROPIUM; CITALOPRAM; CYPROHEPTADINE; DIGESTIVE TRACT SPASMOLYTIC AGENT; ERYTHROMYCIN; FAMOTIDINE; HERBACEOUS AGENT; HYOSCYAMINE; ISPAGULA; LOPERAMIDE; LUBIPROSTONE; MACROGOL 3350; MAGNESIUM OXIDE; METOCLOPRAMIDE; NEOMYCIN; OTILONIUM BROMIDE; PEPPERMINT OIL; PINAVERIUM; PLACEBO; PROBIOTIC AGENT; PSYLLIUM HYDROCOLLOID; RIFAXIMIN; SEROTONIN UPTAKE INHIBITOR; TEGASEROD; TRICYCLIC ANTIDEPRESSANT AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; GASTROINTESTINAL AGENT;

ABDOMINAL PAIN; ACUPUNCTURE; ADOLESCENT; AGITATION; ALTERNATIVE MEDICINE; ANTICHOLINERGIC SYNDROME; BEDTIME DOSAGE; BIFIDOBACTERIUM; BLOATING; BLURRED VISION; BURNING SENSATION; CARDIOVASCULAR DISEASE; CHILD; CHINESE MEDICINE; COGNITIVE THERAPY; CONSTIPATION; DEFECATION URGENCY; DIARRHEA; DIET RESTRICTION; DIETARY FIBER; DIGESTIVE SYSTEM PERFORATION; DOCTOR PATIENT RELATION; DROWSINESS; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; DYSPEPSIA; ESOPHAGUS PAIN; EXTRAPYRAMIDAL SYMPTOM; FATIGUE; FUNCTIONAL ABDOMINAL PAIN; GASTROINTESTINAL PAIN; GUIDED IMAGERY; HEART ARRHYTHMIA; HEARTBURN; HUMAN; HYPNOSIS; IRRITABILITY; IRRITABLE COLON; ISCHEMIC COLITIS; LACTASE DEFICIENCY; LACTOBACILLUS; LACTOSE INTOLERANCE; MALABSORPTION; PLACEBO EFFECT; PSYCHOSOCIAL CARE; QT PROLONGATION; RECTAL BURNING SENSATION; RELAXATION TRAINING; REVIEW; SIDE EFFECT; TACHYCARDIA; URINE RETENTION; VISUAL DISORDER; WHEAT BRAN; XEROSTOMIA; DIET THERAPY; FEMALE; IRRITABLE BOWEL SYNDROME; MALE; PRESCHOOL CHILD; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ABDOMINAL PAIN; ADOLESCENT; CHILD; CHILD, PRESCHOOL; COMPLEMENTARY THERAPIES; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; PARASYMPATHOLYTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 77953254132     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.10.28     Document Type: Review

References (77)

1. Hyams JS, Burke G, Davis PM, Rzepski B, Andrulonis PA. Abdominal pain and irritable bowel syndrome in adolescents: a community-based study. J. Pediatr. 129(2), 220-226 (1996).
2. Saps M, Seshadri R, Sztainberg M, Schaffer G, Marshall BM, Di Lorenzo C. A prospective school-based study of abdominal pain and other common somatic complaints in children. J. Pediatr. 154(3), 322-326 (2009).
3. Starfield B, Hoekelman RA, McCormick M et al. Who provides health care to children and adolescents in the United States? Pediatrics 74(6), 991-997 (1984).
4. Rasquin A, Di Lorenzo C, Forbes D et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 130(5), 1527-1537 (2006).
5. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 130(5), 1480-1491 (2006).
6. Youssef NN, Murphy TG, Langseder AL, Rosh JR. Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions. Pediatrics 117(1), 54-59 (2006).
7. Drossman DA, Li Z, Andruzzi E et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig. Dis. Sci. 38(9), 1569-1580 (1993).
8. Chitkara DK, Talley NJ, Weaver AL et al. Incidence of presentation of common functional gastrointestinal disorders in children from birth to 5 years: a cohort study. Clin. Gastroenterol. Hepatol. 5(2), 186-191 (2007).
9. Campo JV, Di Lorenzo C, Chiappetta L et al. Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it? Pediatrics 108(1), E1 (2001).
10. Drossman D. Presidential address: gastrointestinal illness and the biopsychosocial model. Psychosom. Med. 60(3), 258-267 (1998).
11. Apley J, Naish N. Recurrent abdominal pains: a field survey of 1,000 school children. Arch. Dis. Child. 33(168), 165-170 (1958).
12. Levy RL, Olden KW, Naliboff BD et al. Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology 130(5), 1447-1458 (2006).
13. Saps M, Youssef N, Miranda A et al. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology 137(4), 1261-1269 (2009).
14. Dearlove J, Dearlove B, Pearl K, Primavesi R. Dietary lactose and the child with abdominal pain. Br. Med. J. (Clin. Res. Ed.) 286, 1936 (1983).
15. Lebenthal E, Rossi T, Nord K, Branski D. Recurrent abdominal pain and lactose absorption in children. Pediatrics 67(6), 828-832 (1981).
16. Gomara R, Halata M, Newman L et al. Fructose intolerance in children presenting with abdominal pain. J. Pediatr. Gastroenterol. Nutr. 47(3), 303-308 (2008).
17. Ford A, Talley N, Spiegel B, Foxx-Orenstein A, Schiller L, Quigley E. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. Br. Med. J. 13(337), a2313 (2008).
18. Paulo A, Amancio O, de Morais M, Tabacow K. Low-dietary fiber intake as a risk factor for recurrent abdominal pain in children. Eur. J. Clin. Nutr. 60(7), 823-827 (2006).
19. Feldman W, McGrath P, Hodgson C, Ritter H, Shipman R. The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent, abdominal pain. Results in a prospective, double-blind, randomized controlled trial. Am. J. Dis. Child. 139(12), 1216-1218 (1985).
20. Huertas-Ceballos AA, Logan S, Bennett C, Macarthur C. Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev. 1, CD003019 (2009).
21. Christensen M. Recurrent abdominal pain and dietary fiber. Am. J. Dis. Child. 140(8), 738-739 (1986).
22. Hebden JM, Blackshaw E, D'Amato M, Perkins AC, Spiller RC. Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran on transit and symptoms. Am. J. Gastroenterol. 97(9), 2315-2320 (2002).
23. Lin HC. Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 292(7), 852-858 (2004).
24. Vandenplas Y, Benninga M. Probiotics and functional gastrointestinal disorders in children. J. Pediatr. Gastroenterol. Nutr. 48(Suppl. 2), S107-S109 (2009).
25. Malinen E, Rinttila T, Kajander K et al. Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am. J. Gastroenterol. 100(2), 373-382 (2005).
26. Quigley EM. Probiotics in functional gastrointestinal disorders: what are the facts? Curr. Opin. Pharmacol. 8(6), 704-708 (2008).
27. Moayyedi P, Ford A, Talley N et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59(3), 325-332 (2008).
28. Bausserman M, Michail S. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. J. Pediatr. 147(2), 197-201 (2005).
29. Gawronska A, Dziechciarz P, Horvath A, Szajewska H. A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Aliment. Pharmacol. Ther. 25, 177-184 (2007).
30. Bu LN, Chang MH, Ni YH, Chen HL, Cheng CC. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatr. Int. 49(4), 485-490 (2007).
31. Lackner JM, Mesmer C, Morley S, Dowzer C, Hamilton S. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J. Consult. Clin. Psychol. 72(6), 1100-1113 (2004).
32. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C. Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev. 1, CD003014 (2008).
33. Brent M, Lobato D, LeLeiko N. Psychological treatments for pediatric functional gastrointestinal disorders. J. Pediatr. Gastroenterol. Nutr. 48(1), 13-21 (2009).
34. Bursch B. Psychological/cognitive behavioral treatment of childhood functional abdominal pain and irritable bowel syndrome. J. Pediatr. Gastroenterol. Nutr. 47(5), 706-707 (2008).
35. Walker LS, Williams SE, Smith CA, Garber J, Van Slyke DA, Lipani TA. Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain. Pain 122(1-2), 43-52 (2006).
36. American Academy of Pediatrics Subcommittee on Chronic Abdominal Pain. Chronic abdominal pain in children. Pediatrics 115(3), 812-815 (2005).
37. Ditto B, Eclache M, Goldman N. Short-term autonomic and cardiovascular effects of mindfulness body scan meditation. Ann. Behav. Med. 32(3), 227-234 (2006).
38. Bury RG. A study of 111 children with recurrent abdominal pain. Aust. Paediatr. J. 23(2), 117-119 (1987).
39. Youssef N, Rosh J, Loughran M et al. Treatment of functional abdominal pain in childhood with cognitive behavioral strategies. J. Pediatr. Gastroenterol. Nutr. 39, 192-196 (2004).
40. Sanders MR, Rebgetz M, Morrison M et al. Cognitive-behavioral treatment of recurrent nonspecific abdominal pain in children: an analysis of generalization, maintenance, and side effects. J. Consult. Clin. Psychol. 57(2), 294-300 (1989).
41. Sanders MR, Shepherd RW, Cleghorn G, Woolford H. The treatment of recurrent abdominal pain in children: a controlled comparison of cognitive-behavioral family intervention and standard pediatric care. J. Consult. Clin. Psychol. 62(2), 306-314 (1994).
42. Humphreys P, Gevirtz R. Treatment of recurrent abdominal pain: components analysis of four treatment protocols. J. Pediatr. Gastroenterol. Nutr. 31(1), 47-51 (2000).
43. Robins PM, Smith SM, Glutting JJ, Bishop CT. A randomized controlled trial of a cognitive-behavioral family intervention for pediatric recurrent abdominal pain. J. Pediatr. Psychol. 30(5), 397-408 (2005).
44. Duarte MA, Penna FJ, Andrade EM, Cancela CS, Neto JC, Barbosa TF. Treatment of nonorganic recurrent abdominal pain: cognitive-behavioral family intervention. J. Pediatr. Gastroenterol. Nutr. 43(1), 59-64 (2006).
45. Weydert JA, Shapiro DE, Acra SA, Monheim CJ, Chambers AS, Ball TM. Evaluation of guided imagery as treatment for recurrent abdominal pain in children: a randomized controlled trial. BMC Pediatr. 6, 29 (2006).
46. Vlieger A, Menko-Frankenhuis C, Wolfkamp S, Tromp E, Benninga M. Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome. Gastroenterology 133(5), 1430-1436 (2007).
47. Anbar RD. Self-hypnosis for the treatment of functional abdominal pain in childhood. Clin. Pediatr. (Phila.) 40(8), 447-451 (2001).
48. Lebel AA. Pharmacology. J. Pediatr. Gastroenterol. Nutr. 47(5), 703-705 (2008).
49. Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 58(3), 367-378 (2009).
50. Bridge JA, Iyengar S, Salary CB et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA 297(15), 1683-1696 (2007).
51. Gutgesell H, Atkins D, Barst R et al. Cardiovascular monitoring of children and adolescents receiving psychotropic drugs: a statement for healthcare professionals from the Committee on Congenital Cardiac Defects, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 99(7), 979-982 (1999).
52. Bahar RJ, Collins BS, Steinmetz B, Ament ME. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J. Pediatr. 152(5), 685-689 (2008).
53. Campo J, Perel J, Lucas A et al. Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. J. Am. Acad. Child Adolesc. Psychiatry 43(10), 1234-1242 (2004).
54. Ladabaum U, Sharabidze A, Levin TR et al. Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 8(1), 42-48, e41 (2010).
55. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J. Pediatr. 138(1), 125-128 (2001).
56. Sadeghian M, Farahmand F, Fallahi GH, Abbasi A. Cyproheptadine for the treatment of functional abdominal pain in childhood: a double-blinded randomized placebo-controlled trial. Minerva Pediatr. 60(6), 1367-1374 (2008).
57. See MC, Birnbaum AH, Schechter CB, Goldenberg MM, Benkov KJ. Double-blind, placebo-controlled trial of famotidine in children with abdominal pain and dyspepsia: global and quantitative assessment. Dig. Dis. Sci. 46(5), 985-992 (2001).
58. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132(1), 397-414 (2007).
59. Khoshoo V, Armstead C, Landry L. Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome. Aliment. Pharmacol. Ther. 23(1), 191-196 (2006).
60. Brandt LJ, Chey WD, Foxx-Orenstein AE et al. An evidence-based position statement on the management of irritable bowel syndrome. Am. J. Gastroenterol. 104(Suppl. 1), S1-S35 (2009).
61. Karamanolis G, Tack J. Promotility medications - now and in the future. Dig. Dis. 24(3-4), 297-307 (2006).
62. Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Curr. Opin. Pharmacol. 8(6), 690-696 (2008).
63. Drossman DA, Chey WD, Johanson JF et al. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment. Pharmacol. Ther. 29(3), 329-341 (2009).
64. Cann P, Read N, Holdsworth C, Barends D. Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Dig. Dis. Sci. 29, 239-247 (1984).
65. Pimentel M, Park S, Mirocha J, Kane S, Kong Y. The effect of a nonabsorbed oral antibiotic (rifaxamin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann. Intern. Med. 145(8), 557-563 (2006).
66. Pimentel M, Chatterjee S, Chow E, Park S, Kong Y. Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent of the presence of methane gas: subanalysis of a double-blind randomized controlled study. Dig. Dis. Sci. 51(8), 1297-1301 (2006).
67. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C. Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev. 1, CD003017 (2008).
68. Di Lorenzo C, Colletti RB, Lehmann HP et al. Chronic abdominal pain in children: a technical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 40(3), 249-261 (2005).
69. Vlieger AM, Blink M, Tromp E, Benninga MA. Use of complementary and alternative medicine by pediatric patients with functional and organic gastrointestinal diseases: results from a multicenter survey. Pediatrics 122(2), e446-e451 (2008).
70. Day AS. Use of complementary and alternative therapies and probiotic agents by children attending gastroenterology outpatient clinics. J. Paediatr. Child Health 38(4), 343-346 (2002).
71. Heuschkel R, Afzal N, Wuerth A et al. Complementary medicine use in children and young adults with inflammatory bowel disease. Am. J. Gastroenterol. 97(2), 382-388 (2002).
72. Bensoussan A, Talley NJ, Hing M, Menzies R, Guo A, Ngu M. Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trial. JAMA 280(18), 1585-1589 (1998).
73. Leung WK, Wu JC, Liang SM et al. Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebo-controlled trial. Am. J. Gastroenterol. 101(7), 1574-1580 (2006).
74. Schneider A, Enck P, Streitberger K et al. Acupuncture treatment in irritable bowel syndrome. Gut 55(5), 649-654 (2006).
75. Lembo AJ, Conboy L, Kelley JM et al. A treatment trial of acupuncture in IBS patients. Am. J. Gastroenterol. 104(6), 1489-1497 (2009).
76. Broide E, Pintov S, Portnoy S, Barg J, Klinowski E, Scapa E. Effectiveness of acupuncture for treatment of childhood constipation. Dig. Dis. Sci. 46(6), 1270-1275 (2001).
77. Camilleri M, Chang L. Challenges to the therapeutic pipeline for irritable bowel syndrome: end points and regulatory hurdles. Gastroenterology 135(6), 1877-1891 (2008).