메뉴 건너뛰기




Volumn 23, Issue 3, 2010, Pages 493-505

The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response

Author keywords

Antimicrobial peptide; Lactoferrin; Monocytes; NF B; TLR

Indexed keywords

CELL SURFACE RECEPTOR; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTOFERRIN; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; LACTOFERRIN (1-11), HUMAN; PEPTIDE FRAGMENT;

EID: 77953234577     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-010-9322-4     Document Type: Conference Paper
Times cited : (25)

References (25)
  • 1
    • 68449088241 scopus 로고    scopus 로고
    • Lactoferrin as a natural immune modulator
    • 10.2174/138161209788453202 1:CAS:528:DC%2BD1MXotFKht7k%3D 19519436
    • JK Actor SA Hwang ML Kruzel 2009 Lactoferrin as a natural immune modulator Curr Pharm Des 15 1956 1973 10.2174/138161209788453202 1:CAS:528:DC%2BD1MXotFKht7k%3D 19519436
    • (2009) Curr Pharm des , vol.15 , pp. 1956-1973
    • Actor, J.K.1    Hwang, S.A.2    Kruzel, M.L.3
  • 2
    • 0031839843 scopus 로고    scopus 로고
    • Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111
    • 1:CAS:528:DyaK1cXjs1eisbs%3D 9596699
    • DS Chapple DJ Mason CL Joannou EW Odell V Gant RW Evans 1998 Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111 Infect Immun 66 2434 2440 1:CAS:528:DyaK1cXjs1eisbs%3D 9596699
    • (1998) Infect Immun , vol.66 , pp. 2434-2440
    • Chapple, D.S.1    Mason, D.J.2    Joannou, C.L.3    Odell, E.W.4    Gant, V.5    Evans, R.W.6
  • 3
    • 0026716209 scopus 로고
    • Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin
    • 1:CAS:528:DyaK38XkvVynsrw%3D 1535239
    • SP Crouch KJ Slater J Fletcher 1992 Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin Blood 80 235 240 1:CAS:528:DyaK38XkvVynsrw%3D 1535239
    • (1992) Blood , vol.80 , pp. 235-240
    • Crouch, S.P.1    Slater, K.J.2    Fletcher, J.3
  • 4
    • 33845464963 scopus 로고    scopus 로고
    • Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways
    • DOI 10.1016/j.cellimm.2006.08.006, PII S0008874906001523
    • CS Curran KP Demick JM Mansfield 2006 Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways Cell Immunol 242 23 30 10.1016/j.cellimm.2006.08.006 1:CAS:528:DC%2BD28XhtlaltbjO 17034774 (Pubitemid 44894393)
    • (2006) Cellular Immunology , vol.242 , Issue.1 , pp. 23-30
    • Curran, C.S.1    Demick, K.P.2    Mansfield, J.M.3
  • 5
    • 9644287934 scopus 로고    scopus 로고
    • The synthetic n-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii
    • DOI 10.1128/AAC.48.12.4919-4921.2004
    • L Dijkshoorn CP Brouwer SJP Bogaards A Nemec PJ van den Broek PH Nibbering 2004 The synthetic n-terminal peptide of human lactoferin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii Antimicrob Agents Chemother 48 4919 4921 10.1128/AAC.48.12.4919-4921.2004 1:CAS:528:DC%2BD2cXhtVKmt7bJ 15561882 (Pubitemid 39577708)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.12 , pp. 4919-4921
    • Dijkshoorn, L.1    Brouwer, C.P.J.M.2    Bogaards, S.J.P.3    Nemec, A.4    Van Den Broek, P.J.5    Nibbering, P.H.6
  • 6
    • 61449099474 scopus 로고    scopus 로고
    • Lactoferrin: Structure, function and applications
    • 10.1016/j.ijantimicag.2008.07.020 1:CAS:528:DC%2BD1MXivVKgs7s%3D
    • SA Gonzalez-Chavez S Revalo-Gallegos Q Rascon-Cruz 2009 Lactoferrin: structure, function and applications Int J Antimicrob Agents 33 301.e1 301.e8 10.1016/j.ijantimicag.2008.07.020 1:CAS:528:DC%2BD1MXivVKgs7s%3D
    • (2009) Int J Antimicrob Agents , vol.33
    • Gonzalez-Chavez, S.A.1    Revalo-Gallegos, S.2    Rascon-Cruz, Q.3
  • 7
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • DOI 10.1038/nri1733
    • S Gordon PR Taylor 2005 Monocyte and macrophage heterogeneity Nat Rev Immunol 5 953 964 10.1038/nri1733 1:CAS:528:DC%2BD2MXht1Kntr3N 16322748 (Pubitemid 41746764)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 8
    • 17744405513 scopus 로고    scopus 로고
    • Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-κB
    • DOI 10.1016/S0008-8749(03)00006-6
    • L Haversen BG Ohlsson M Hahn-Zoric LA Hanson I Mattsby-Baltzer 2002 Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B Cell Immunol 220 83 95 10.1016/S0008-8749(03)00006-6 1:CAS:528:DC%2BD3sXitlWhtbk%3D 12657243 (Pubitemid 36349060)
    • (2002) Cellular Immunology , vol.220 , Issue.2 , pp. 83-95
    • Haversen, L.1    Ohlsson, B.G.2    Hahn-Zoric, M.3    Hanson, L.A.4    Mattsby-Baltzer, I.5
  • 9
    • 73849146045 scopus 로고    scopus 로고
    • Structure-microbicidal activity relationship of synthetic fragments derived from the antibacterial alpha-helix of human lactoferrin
    • 10.1128/AAC.00908-09 1:STN:280:DC%2BD1MfjtlyntQ%3D%3D 19917761
    • L Haversen N Kondori L Baltzer LA Hanson GT Dolphin K Duner I Mattsby-Baltzer 2010 Structure-microbicidal activity relationship of synthetic fragments derived from the antibacterial alpha-helix of human lactoferrin Antimicrob Agents Chemother 54 418 425 10.1128/AAC.00908-09 1:STN:280: DC%2BD1MfjtlyntQ%3D%3D 19917761
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 418-425
    • Haversen, L.1    Kondori, N.2    Baltzer, L.3    Hanson, L.A.4    Dolphin, G.T.5    Duner, K.6    Mattsby-Baltzer, I.7
  • 10
    • 30044434256 scopus 로고    scopus 로고
    • The mononuclear phagocyte system
    • DOI 10.1016/j.coi.2005.11.008, PII S0952791505002013, Innate Immunity/Antigen Processing and Recognition
    • DA Hume 2006 The mononuclear phagocyte system Curr Opin Immunol 18 49 53 10.1016/j.coi.2005.11.008 1:CAS:528:DC%2BD28XhvFOgsw%3D%3D 16338128 (Pubitemid 43049647)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.1 , pp. 49-53
    • Hume, D.A.1
  • 14
    • 0035112330 scopus 로고    scopus 로고
    • Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria
    • DOI 10.1128/IAI.69.3.1469-1476.2001
    • PH Nibbering E Ravensbergen MM Welling LA van Berkel PH van Berkel EK Pauwels JH Nuijens 2001 Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria Infect Immun 69 1469 1476 10.1128/IAI.69.3.1469-1476.2001 1:CAS:528:DC%2BD3MXitFGrt7Y%3D 11179314 (Pubitemid 32187596)
    • (2001) Infection and Immunity , vol.69 , Issue.3 , pp. 1469-1476
    • Nibbering, P.H.1    Ravensbergen, E.2    Welling, M.M.3    Van Berkel, L.A.4    Van Berkel, P.H.C.5    Pauwels, E.K.J.6    Nuijens, J.H.7
  • 16
    • 73449125791 scopus 로고    scopus 로고
    • A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat
    • 10.1097/SLA.0b013e3181b246a7 19953722
    • E Nilsson C Bjorn V Sjostrand K Lindgren M Munnich I Mattsby-Baltzer ML Ivarsson K Olmarker M Mahlapuu 2009 A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat Ann Surg 250 1021 1028 10.1097/SLA.0b013e3181b246a7 19953722
    • (2009) Ann Surg , vol.250 , pp. 1021-1028
    • Nilsson, E.1    Bjorn, C.2    Sjostrand, V.3    Lindgren, K.4    Munnich, M.5    Mattsby-Baltzer, I.6    Ivarsson, M.L.7    Olmarker, K.8    Mahlapuu, M.9
  • 17
    • 0029930976 scopus 로고    scopus 로고
    • Antibacterial activity of peptides homologous to a loop region in human lactoferrin
    • DOI 10.1016/0014-5793(96)00168-8
    • EW Odell R Sarra M Foxworthy DS Chapple RW Evans 1996 Antibacterial activity of peptides homologous to a loop region in human lactoferrin FEBS Lett 382 175 178 10.1016/0014-5793(96)00168-8 1:CAS:528:DyaK28Xhslehsbc%3D 8612745 (Pubitemid 26092948)
    • (1996) FEBS Letters , vol.382 , Issue.1-2 , pp. 175-178
    • Odell, E.W.1    Sarra, R.2    Foxworthy, M.3    Chapple, D.S.4    Evans, R.W.5
  • 18
    • 58149140244 scopus 로고    scopus 로고
    • Immunomodulatory effects of lactoferrin on antigen presenting cells
    • 10.1016/j.biochi.2008.05.005 1:CAS:528:DC%2BD1MXktF2hsQ%3D%3D 18539153
    • P Puddu P Valenti S Gessani 2009 Immunomodulatory effects of lactoferrin on antigen presenting cells Biochimie 91 11 18 10.1016/j.biochi.2008.05.005 1:CAS:528:DC%2BD1MXktF2hsQ%3D%3D 18539153
    • (2009) Biochimie , vol.91 , pp. 11-18
    • Puddu, P.1    Valenti, P.2    Gessani, S.3
  • 19
    • 14744275370 scopus 로고    scopus 로고
    • IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin
    • DOI 10.1016/j.cyto.2004.12.005
    • EF Schippers C van't Veer S van Voorden CA Martina TW Huizinga CS Le JT van Dissel 2005 IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin Cytokine 29 215 228 10.1016/j.cyto.2004.12.005 1:CAS:528:DC%2BD2MXitFequ7k%3D 15760678 (Pubitemid 40326608)
    • (2005) Cytokine , vol.29 , Issue.5 , pp. 215-228
    • Schippers, E.F.1    Van't Veer, C.2    Van Voorden, S.3    Martina, C.A.E.4    Huizinga, T.W.J.5    Le Cessie, S.6    Van Dissel, J.T.7
  • 21
    • 48749104758 scopus 로고    scopus 로고
    • Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells
    • 10.1096/fj.07-098038 1:CAS:528:DC%2BD1cXpsVygsLg%3D 18364398
    • M Spadaro C Caorsi P Ceruti A Varadhachary G Forni F Pericle M Giovarelli 2008 Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells FASEB J 22 2747 2757 10.1096/fj.07-098038 1:CAS:528:DC%2BD1cXpsVygsLg%3D 18364398
    • (2008) FASEB J , vol.22 , pp. 2747-2757
    • Spadaro, M.1    Caorsi, C.2    Ceruti, P.3    Varadhachary, A.4    Forni, G.5    Pericle, F.6    Giovarelli, M.7
  • 23
    • 0030664951 scopus 로고    scopus 로고
    • N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA
    • 9359845
    • PH van Berkel ME Geerts HA van Veen M Mericskay HA de Boer JH Nuijens 1997 N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA Biochem J 328 Pt 1 145 151 9359845
    • (1997) Biochem J , vol.328 , Issue.PART 1 , pp. 145-151
    • Van Berkel, P.H.1    Geerts, M.E.2    Van Veen, H.A.3    Mericskay, M.4    De Boer, H.A.5    Nuijens, J.H.6
  • 24
    • 75749088351 scopus 로고    scopus 로고
    • Antimicrobial peptide hLF1-11 directs GM-CSF-driven monocyte differentiation towards macrophages with enhanced recognition and clearance of pathogens
    • 10.1128/AAC.00652-09 19933796
    • AM van der Does SJP Bogaards E Ravensbergen H Beekhuizen JT van Dissel PH Nibbering 2010 Antimicrobial peptide hLF1-11 directs GM-CSF-driven monocyte differentiation towards macrophages with enhanced recognition and clearance of pathogens Antimicrob Agents Chemother 54 811 816 10.1128/AAC.00652-09 19933796
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 811-816
    • Van Der Does, A.M.1    Bogaards, S.J.P.2    Ravensbergen, E.3    Beekhuizen, H.4    Van Dissel, J.T.5    Nibbering, P.H.6
  • 25
    • 70350708570 scopus 로고    scopus 로고
    • Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11)
    • 10.1186/1741-7015-7-44 19735580
    • WF van der Velden TMP van Iersel NMA Blijlevens JP Donnelly 2009 Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11) BMC Med 7 44 10.1186/1741-7015-7-44 19735580
    • (2009) BMC Med , vol.7 , pp. 44
    • Van Der Velden, W.F.1    Van Iersel, T.M.P.2    Blijlevens, N.M.A.3    Donnelly, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.