Administration of thebisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats

Calcified Tissue International

Volumn 86, Issue 6, 2010, Pages 502-510

  Hiraga, Toru ^a   Ninomiya, Tadashi ^a   Hosoya, Akihiro ^a   Nakamura, Hiroaki ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Bisphosphonate; Dental abnormality; Odontoma; Tooth eruption; Zoledronic acid

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; ZOLEDRONIC ACID; BONE DENSITY CONSERVATION AGENT; IMIDAZOLE DERIVATIVE;

ALVEOLAR BONE; AMELOBLAST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DRUG EFFICACY; DRUG SAFETY; ENAMEL; EPITHELIUM; GROWTH INHIBITION; HISTOPATHOLOGY; INCISOR; MALE; MANDIBLE; MESENCHYME; MOLAR TOOTH; NONHUMAN; ODONTOGENIC TUMOR; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT; TOOTH CROWN; TOOTH DEVELOPMENT; TOOTH DISEASE; TOOTH ERUPTION; TOOTH MALFORMATION; TOOTH ROOT; X RAY; ANIMAL; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; NICK END LABELING; PATHOLOGY; TOOTH; WISTAR RAT;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; ODONTOGENESIS; RATS; RATS, WISTAR; TOMOGRAPHY, X-RAY COMPUTED; TOOTH; TOOTH ERUPTION;

EID: 77953232275     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9366-z     Document Type: Article

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