Blockade of airway sensory nerves and dyspnea in humans

Pulmonary Pharmacology and Therapeutics

Volumn 23, Issue 4, 2010, Pages 279-282

  Burki, Nausherwan K ^a   Lee, Lu Yuan ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Adenosine; Dyspnea; Lidocaine; Theophylline; Vagal C fibers

Indexed keywords

ADENOSINE; LIDOCAINE; PLACEBO; THEOPHYLLINE;

ABSENCE OF SIDE EFFECTS; ADULT; ANXIETY; ARTICLE; BREATHING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DYSPNEA; FEMALE; HAND GRIP; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; MALE; NERVE BLOCK; NERVE POTENTIAL; NORMAL HUMAN; PRIORITY JOURNAL; SENSORY RECEPTOR; SIDE EFFECT; SODIUM TRANSPORT; TACHYCARDIA; VAGUS NERVE;

ADOLESCENT; ADULT; ANESTHETICS, LOCAL; DOUBLE-BLIND METHOD; DYSPNEA; FEMALE; HUMANS; LIDOCAINE; MALE; MIDDLE AGED; NERVE BLOCK; NERVE FIBERS, UNMYELINATED; RECEPTORS, PURINERGIC P1; SODIUM CHANNELS; THEOPHYLLINE; VAGUS NERVE; YOUNG ADULT;

EID: 77953230424     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2010.02.002     Document Type: Article

References (27)

1. Guz A. Respiratory sensations in man. Br Med Bull 33 2 (1977) 175-177
2. Davies S.F., McQuaid K.R., Iber C., McArthur C.D., Path M.J., Beebe D.S., et al. Extreme dyspnea from unilateral pulmonary venous obstruction. Demonstration of a vagal mechanism and relief by right vagotomy. Am Rev Respir Dis 136 (1987) 184-188
3. Burki N.K., Dale W.J., and Lee L.-Y. Intravenous adenosine and dyspnea in man. J Appl Physiol 98 (2005) 180-185
4. Burki N.K., Alam M., and Lee L.Y. The pulmonary effects of intravenous adenosine in asthmatic subjects. Respir Res 7 (2006) 139
5. Burki N.K., Sheatt M., and Lee L.-Y. Effects of airway anesthesia on dyspnea and ventilatory response to intravenous injection of adenosine in healthy human subjects. Pulm Pharmacol Ther 21 1 (2008) 208-213
6. Winning A.J., Hamilton R.D., Shea S.A., and Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity. Clin Sci 71 (1986) 519-526
7. Dicpinigaitis P.V. Experimentally induced cough. Pulm Pharmacol Ther 20 (2007) 319-324
8. Jain S.K., Subramanian S., Julka D.B., and Guz A. Search for evidence of lung chemoreflexes in man: study of respiratory and circulatory effects of phenyldiguanide and lobeline. Clin Sci 42 (1972) 163-177
9. Raj H., Bakshi G.S., Tiwari R.R., Anand A., and Paintal A.S. How does lobeline injected intravenously produce a cough?. Respir Physiol Neurobiol 145 (2005) 79-90
10. Gandevia S.C., Butler J.E., Taylor J.L., and Crawford M.R. Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres. J Physiol 511 (1998) 289-300
11. Undem B.J., and Nassenstein C. Airway nerves and dyspnea associated with inflammatory airway disease. Respir Physiol Neurobiol 167 (2009) 36-44
12. Lee L.Y. Respiratory sensations evoked by activation of bronchopulmonary C-fibers. Respir Physiol Neurobiol 167 1 (2009) 26-35
13. Burki N. Effects of bronchodilation on magnitude estimation of added resistive loads in asthmatic subjects. Am Rev Respir Dis 129 (1984) 225-229
14. Liistro G., Stanescu D., Rodenstein D., and Veriter C. Reassessment of the interruption technique for measuring airflow resistance in humans. J Appl Physiol 67 (1989) 933-937
15. Zechman F.W., Wiley R.L., and Davenport P.W. Ability of healthy men to discriminate between added inspiratory resisitive and elastic loads. Respir Physiol 45 (1981) 111-120
16. Muza S.R., and Zechman F.W. Scaling of added loads to breathing: magnitude estimation vs handgrip matching. J Appl Physiol 57 (1984) 888-891
17. Armitage P., Berry G., and Matthews J.N.S. Statistical methods in Medical Research. 4th ed. (2002), Blackwell Science Ltd, Iowa State University Press, Ames, Iowa p. 225-227, and 432-435
18. Hong J.L., Ho C.Y., Kwong K., and Lee L.Y. Activation of pulmonary C fibers by adenosine in anaesthetized rats: role of adenosine A1 receptors. J Physiol (Lond) 508 (1998) 109-118
19. Chaudhary B.A., and Burki N.K. The effects of airway anesthesia on detection of added inspiratory elastic loads. Am Rev Respir Dis 122 (1980) 635-640
20. Dolovich M.B. 18F-fluorodeoxyglucose positron emission tomographic imaging of pulmonary functions, pathology, and drug delivery. Proc Am Thorac Soc 6 5 (2009) 477-485
21. Jammes Y., Fornaris E., Mei N., and Barrat E. Afferent and efferent components of the bronchial vagal branches in cats. J Auton Nerv Syst 5 (1982) 165-176
22. Chou Y.L., Scarupa M.D., Mori N., and Canning B.J. Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 295 5 (2008) R1572-R1584
23. Butler J.E., Anand A., Crawford M.R., Glanville A.R., McKenzie D.K., Paintal A.S., et al. Changes in respiratory sensations induced by lobeline after human bilateral lung transplantation. J Physiol 534 Pt 2 (2001) 583-593
24. Winning A.J., Hamilton R.D., Shea S.A., Knott C., and Guz A. The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man. Clin Sci (Lond) 68 2 (1985) 215-225
25. 2 in healthy subjects. J Appl Physiol 74 (1993) 1419-1424
26. Undem B.J., Chuaychoo B., Lee M.G., Weinreich D., Myers A.C., and Kollarik M. Subtypes of vagal afferent C-fibres in guinea-pig lungs. J Physiol 556 (2004) 905-917
27. Chuaychoo B., Lee M.G., Kollarik M., Pullmann Jr. R., and Undem B.J. Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs. J Physiol 575 (2006) 481-490