COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke

Experimental and Translational Stroke Medicine

Volumn 2, Issue 1, 2010, Pages

  Kraft, Peter ^a   Schwarz, Tobias ^a   Pochet, Lionel ^b   Stoll, Guido ^a   Kleinschnitz, Christoph ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; COU 254; COUMARIN DERIVATIVE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFICACY; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; IMMUNOBLOTTING; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SCORING SYSTEM; STAINING; THROMBOGENESIS; WESTERN BLOTTING;

EID: 77953219775     PISSN: None     EISSN: 20407378     Source Type: Journal    
DOI: 10.1186/2040-7378-2-5     Document Type: Article

References (26)

1. Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets fortreatment. Blood 2008, 112:3555-3562. 10.1182/blood-2008-04-144758, 18676880.
2. Sandercock PA, Counsell C, Kamal A. Anticoagulants for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2008, (4):CD000024.
3. Levine MN, Raskob G, Landefeld S, Kearon C. Hemorrhagic complications of anticoagulant treatment. Chest 2001, 119(Suppl 1):108S-121S. 10.1378/chest.119.1_suppl.108S, 11157645.
4. Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964, 145:1310-1312. 10.1126/science.145.3638.1310, 14173416.
5. Macfarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 1964, 202:498-499. 10.1038/202498a0, 14167839.
6. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004, 24:1015-1022. 10.1161/01.ATV.0000130465.23430.74, 15117736.
7. Gailani D, Renné T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol 2007, 27:2507-2513. 10.1161/ATVBAHA.107.155952, 17916770.
8. Ratnoff OD, Colopy JE. A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma. J Clin Invest 1955, 34:602-613. 10.1172/JCI103109, 438666, 14367514.
9. Gailani D, Broze GJ. Factor XI activation in a revised model of blood coagulation. Science 1991, 253:909-912. 10.1126/science.1652157, 1652157.
10. Renne T, Pozgajova M, Gruner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B. Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 2005, 202:271-281. 10.1084/jem.20050664, 2213000, 16009717.
11. Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, Burfeind P, Renné C, Gailani D, Nieswandt B, Renné T. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 2006, 203:513-518. 10.1084/jem.20052458, 2118228, 16533887.
12. Robert S, Bertolla C, Masereel B, Dogné JM, Pochet L. Novel 3-Carboxamide-coumarins as Potent and Selective FXIIa Inhibitors. J Med Chem 2008, 51:3077-3080. 10.1021/jm8002697, 18459730.
13. Dirnagl U. Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab 2006, 26:1465-78. 10.1038/sj.jcbfm.9600298, 16525413.
14. Berna-Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B. STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal 2009, 2:ra67. 10.1126/scisignal.2000522, 19843959.
15. Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, Stoll G, Renné T, Kleinschnitz C. Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 2009, 40:285-93. 10.1161/STROKEAHA.108.526673, 18988906.
16. Ikeda K, Monden T, Kanoh T, Tsujie M, Izawa H, Haba A, Ohnishi T, Sekimoto M, Tomita N, Shiozaki H, Monden M. Extraction and analysis of diagnostically useful proteins from formalin-fixed, paraffin-embedded tissue sections. J Histochem Cytochem 1998, 46:397-403.
17. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
18. Moran PM, Higgins LS, Cordell B, Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human amyloid precursor protein. Proc Natl Acad Sci 1995, 92:5341-5345. 10.1073/pnas.92.12.5341, 41690, 7777509.
19. Connolly ES, Winfree CJ, Stern DM, Solomon RA, Pinsky DJ. Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery 1996, 38:523-532. 10.1097/00006123-199603000-00021, 8837805.
20. Gailani D, Renné T. The intrinsic pathway of coagulation:a target for treating thromboembolic disease?. J Thromb Haemost 2007, 5:1106-12. 10.1111/j.1538-7836.2007.02446.x, 17388803.
21. Carter TH, Everson BA, Ratnoff OD. Cabbage seed protease inhibitor: a slow, tight-binding inhibitor of trypsin with activity toward thrombin, activated Stuart factor (factor Xa), activated Hageman factor (factor XIIa), and plasmin. Blood 1990, 75:108-115.
22. Campos IT, Tanaka-Azevedo AM, Tanaka AS. Identification and characterization of a novel factor XIIa inhibitor in the hematophagous insect, Triatoma infestans (Hemiptera: Reduviidae). FEBS Lett 2004, 577:512-516. 10.1016/j.febslet.2004.10.052, 15556638.
23. Isawa H, Orito Y, Jingushi N, Iwanaga S, Morita A, Chinzei Y, Yuda M. Identification and characterization of plasma kallikrein-kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans. FEBS J 2007, 274:4271-86. 10.1111/j.1742-4658.2007.05958.x, 17645545.
24. Decrem Y, Rath G, Blasioli V, Cauchie P, Robert S, Beaufays J, Frère JM, Feron O, Dogné JM, Dessy C, Vanhamme L, Godfroid E. Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis. J Exp Med 2009, 206:2381-95. 10.1084/jem.20091007, 19808248.
25. Foster CB, Flanigan TP, DeStigter KK, Blanton R, Dumenco LL, Gallagher C, Ratnoff OD. Inhibition of the activation of Hageman factor (factor XII) by extracts of Schistosoma mansoni. J Lab Clin Med 1992, 120:735-739.
26. Ulmer JS, Lindquist RN, Dennis MS, Lazarus RA. Ecotin is a potent inhibitor of the contact system proteases factor XIIa and plasma kallikrein. FEBS Lett 1995, 365:159-163. 10.1016/0014-5793(95)00466-M, 7781771.