Antioxidant and nephroprotective activity of Spathodea campanulata bark against gentamicin induced nephrotoxicity

Pharmacologyonline

Volumn 1, Issue , 2010, Pages 666-675

  Shanmukha, I ^a   Siddiq, Abubaker ^a   Kamlesh, Gupt ^a   Khan, Majam ^a   Ramachandra Setty, S ^a  

^a SCS College of Pharmacy   (India)

Author keywords

Antioxidant; Gentamicin; GSH; Lipid peroxidation; Marker enzymes

Indexed keywords

ALCOHOL; CREATININE; GENTAMICIN; GLUTATHIONE; LIPID PEROXIDE; NITRIC OXIDE; NITROGEN; PLANT EXTRACT; SPATHODEA CAMPANULATA EXTRACT; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DOSE COMPARISON; FEMALE; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; RAT; RENAL PROTECTION; SPATHODEA CAMPANULATA; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL;

EID: 77953209274     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Naznin Ara, Hasan Nur. In vitro antioxidant activity of methanolic leaves and flowers extracts of Lippia Alba. Research Journal of Medicine and Medical Sciences 2009; 4(1): 107-110.
2. Jain PK, Agrawal RK. Antioxidant and free radical scavenging properties of developed mono- and polyherbal Formulations. Asian J. Exp. Sci., 2008; 22 (3): 213-220.
3. Ali BH. Gentamicin nephrotoxicity in humans and animals: Some recent research. Gen Pharmacol 1995; 26: 1477-87.
4. Mathew TH. Drug-induced renal disease. Med J Aust 1992; 156: 724-28.
5. Ramsammy L, Ling KY, Josepovitz C, et al. Effect of gentamicin on lipid peroxidation in rat renal cortex. Biochem Pharmacol 1985; 34: 3895-900.
6. Yang C, Du X, Han Y. Renal cortical mitochondria are the source of oxygen free radicals enhanced by gentamicin. Renal Fail 1995; 17: 21-26.
7. Feldman S, Wang M, Kaloyanides GJ. Aminoglycosides induce a phospholipidosis in the renal cortex of the rat: An early manifestation of nephrotoxicity. J Pharmacol Exp Therp 1982; 220: 514-20.
8. Adriana pianaro, jurandir Pereira pinto et al. Iridoid glucoside and antifungal phenolic compounds from Spathodea campanulata roots. Ciencias agrarias, Londrina June 2007; 28(2):251-256.
9. Ayyappa Das MP, Dhanabalan R, Doss A. Invitro anti bacterial activity of Spathodea campanulata against Bovine under isolated bacterial pathogens from dairy herbs. Ethanobotanical leaflets 2009; 13: 153-58.
10. Mrs. Prema Veeraraghavan. Expert consultant, CPCSEA, OECD guideline No. 420; Oct. 2000.
11. Oyaizu M. Studies on product of browning reaction preparation from glucose amine. Jap J Nutrition 1986; 44: 307-09.
12. Rekha Rajendran, Saleem Basha N, Ruby S. Evaluation of in-vitro antioxidant activity of stem-bark and stem-wood of Premna serratifolia. Research J. Pharmacognosy and Phytochemistry, July 2009; 1(1):11-14.
13. Sangameswaran B, Balakrishnan BR, Chumbhale Deshraj, Jayakar B. Invitro antioxidant activity of roots of Thespesia lampas Dalz and Gibs. Pak. J. Pharm. Sci., October 2009; 22(4): 368-372.
14. Vijaj Kumar K, Naidu MUR, Anwar A, Shifow, Ratnakar KS. Probucol protects against gentamicin induced nephrotoxicity in rats. Ind J Pharmacol 2000; 32: 108-13.