No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness

Experimental Biology and Medicine

Volumn 235, Issue 6, 2010, Pages 737-740

  Wang, Pei ^a   Koehle, Michael S ^a,b   Rupert, Jim L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Altitude; Bradykinin; Bradykinin receptor; Hypoxia; Nepalese

Indexed keywords

BRADYKININ B2 RECEPTOR; DNA;

ALTITUDE DISEASE; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE FREQUENCY; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; INDEL MUTATION; MAJOR CLINICAL STUDY; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ALTITUDE SICKNESS; DISEASE SUSCEPTIBILITY; GENE FREQUENCY; POLYMORPHISM, GENETIC; RECEPTORS, BRADYKININ;

EID: 77953208844     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2010.009325     Document Type: Article

References (27)

1. Hackett PH, Roach RC. High-altitude illness. N Engl J Med 2001;345:107-114
2. West JB. The physiologic basis of high-altitude diseases. Ann Intern Med 2004;141:789-800
3. Bartsch P, Bailey DM, Berger MM, Knauth M, Baumgartner RW. Acute mountain sickness: controversies and advances. High Alt Med Biol 2004;5:110-124
4. Rupert JL, Koehle MS. Evidence for a genetic basis for altitude-related illness. High Alt Med Biol 2006;7:150-167
5. Schoene RB. Illnesses at high altitude. Chest 2008;134:402-416
6. Wilson MH, Newman S, Imray CH. The cerebral effects of ascent to high altitudes. Lancet Neurol 2009;8:175-191
7. Basnyat B, Murdoch DR. High-altitude illness. Lancet 2003;361:1967-1974
8. Schneider M, Bernasch D, Weymann J, Holle R, Bartsch P. Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate. Med Sci Sports Exerc 2002;34:1886-1891 (Pubitemid 35440406)
9. Koehle MS, Wang P, Guenette JA, Rupert JL. No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 metres. High Alt Med Biol 2006;7:281-289
10. Wang P, Koehle MS, Rupert JL. Common haplotypes in the β-2 adrenergic receptor gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt Med Biol 2007;8:206-212
11. Kalson NS, Thompson J, Davies AJ, Stokes S, Earl MD, Whitehead A, Tyrrell-Marsh I, Frost H, Montgomery H. The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m). Eur J Appl Physiol 2009;105:373-379
12. Qia Y, Niuc WQ, Zhue TC, Liue JL, Donge WY, Xue Y, Dinge SQ, Cuie CB, Pane YJ, Yue GS, Zhoua WY, Qiua CC. Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4,000 meters. Clin Chim Acta 2009;405:17-22
13. Tom B, Dendorfer A, Danser AH. Bradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact? Int J Biochem Cell Biol 2003;35:792-801
14. Venema RC. Post-translational mechanisms of endothelial nitric oxide synthase regulation by bradykinin. Int Immunopharmacol 2002;2:1755-1762
15. Beall CM, Laskowski D, Strohl KP, Soria R, Villena M, Vargas E, Alarcon AM, Gonzales C, Erzurum SC. Pulmonary nitric oxide in mountain dwellers. Nature 2001;414:411-412
16. Busch T, Bartsch P, Pappert D, Grunig E, Hildebrandt W, Elser H, Falke KJ, Swenson ER. Hypoxia decreases exhaled nitric oxide in mountaineers susceptible to high-altitude pulmonary edema. Am J Respir Crit Care Med 2001;163:368-373 (Pubitemid 32158514)
17. Montgomery HE, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C, Hayward M, Holliman DE, Jubb M, World M, Thomas EL, Brynes AE, Saeed N, Barnard M, Bell JD, Prasad K, Rayson M, Talmud PJ, Humphries S. Human gene for physical performance. Nature 1998;393:221-222
18. Braun A, Kammerer S, Maier E, Bohme E, Roscher AA. Polymorphisms in the gene for the human B2-bradykinin receptor. New tools in assessing a genetic risk for bradykinin-associated diseases. Immunopharmacology 1996;33:32-35
19. Lung CC, Chan EK, Zuraw BL. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol 1997;99(Part 1):134-146
20. Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin Pharmacol Ther 2008;83:122-129
21. Mukae S, Aoki S, Itoh S, Nishio K, Iwata T, Ueda H, Geshi E, Fuzimaki T, Katagiri T. Promoter polymorphism of the beta2 bradykinin receptor gene is associated with essential hypertension. Jpn Circ J 1999;63:759-762
22. Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension 2008;51:454-459
23. Saunders CJ, Xenophontos SL, Cariolou MA, Anastassiades LC, Noakes TD, Collins M. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. Hum Mol Genet 2006;15:979-987
24. Wang P, Koehle MS, Rupert JL. Genotype at the missense G894T polymorphism (Glu298Asp) in the NOS3 gene is associated with the susceptibility to acute mountain sickness. High Alt Med Biol 2009;10:261-267
25. Basnyat B, Subedi D, Sleggs J, Lemaster J, Bhasyal G, Aryal B, Subedi N. Disoriented and ataxic pilgrims: an epidemiological study of acute mountain sickness and high-altitude cerebral edema at a sacred lake at 4300 m in the Nepal Himalayas. Wilderness Environ Med 2000;11:89-93 (Pubitemid 30437378)
26. Fischer M, Lieb W, Marold D, Berthold M, Baessler A, Lowel H, Hense HW, Hengstenberg C, Holmer S, Schunkert H, Erdmann J. Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction. Clin Sci (Lond) 2004;107:505-511
27. Hartl DL. A Primer of Population Genetics. 3rd edn. Sunderland, MA: Sinauer Associates Inc, 2000