Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations

Journal of Rheumatology

Volumn 37, Issue 6, 2010, Pages 1164-1167

  Wipff, Julien ^a,b   Bonnet, Pierre ^b   Ruiz, Barbara ^b   Dieude, Philippe ^a   Avouac, Jerome ^a,b   Tiev, Kiet ^c   Hachulla, Eric ^d   Cracowski, Jean Luc ^e   Diot, Elizabeth ^f   Sibilia, Jean ^g   Mouthon, Luc ^a   Meyer, Olivier ^a   Kahan, Andre ^a   Boileau, Catherine ^b,h   Allanore, Yannick ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c HÔPITAL SAINT ANTOINE   (France)

^d UNIV LILLE   (France)

^e GRENOBLE UNIVERSITY HOSPITAL   (France)

^f CHU BRETONNEAU   (France)

^g UNIVERSITÉ DE STRASBOURG   (France)

^h HÔPITAL AMBROISE PARÉ   (France)

Author keywords

5 HTT (SLC6A4); Polymorphisms; Pulmonary arterial hypertension; Systemic sclerosis

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE MAP; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC SCLEROSIS; ULCER;

COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRANCE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION, PULMONARY; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RAYNAUD DISEASE; SCLERODERMA, SYSTEMIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SKIN ULCER;

EID: 77953207462     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.091156     Document Type: Article

References (15)

1. Allanore Y, Avouac J, Kahan A. Systemic sclerosis: an update in 2008. Joint Bone Spine 2008;75:650-655
2. Machado RD, Eickelberg O, Elliott G, Geraci MW, Hanaoka M, Chung WK, et al. Genetics and genomics of pulmonary hypertension. J Am Coll Cardiol 2009;54:32-42.
3. Marcos E, Fadel E, Sanchez O, Humbert M, Dartevelle P, Simonneau G, et al. Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ Res 2004;94:1263-1270
4. Eddahibi S, Humbert M, Fadel E, Raffestin B, Darmon M, Adnot S, et al. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest 2001;108:1141-1150
5. Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Phillips JA III, et al. Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2006;173:798-802.
6. Eddahibi S, Chaouat A, Morrell N, Fadel E, Fuhrman C, Bugnet AS, et al. Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. Circulation 2003;108:1839-1844
7. Wipff J, Kahan A, Hachulla E, Sibilia J, Cabane J, Meyer O, et al. Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension. Rheumatology 2007;46:622-625
8. Kawaguchi Y, Tochimoto A, Hara M, Kawamoto M, Sugiura T, Katsumata Y, et al. NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. Arthritis Res Ther 2006;8:R104.
9. Marasini B, Cossutta R, Selmi C, Pozzi MR, Gardinali M, Massarotti M, et al. Polymorphism of the fractalkine receptor CX3CR1 and systemic sclerosis-associated pulmonary arterial hypertension. Clin Dev Immunol 2005;12:275-279
10. Manetti M, Liakouli V, Fatini C, Cipriani P, Bonino C, Vettori S, et al. Association between a stromal cell-derived factor 1 (SDF-1/CXCL12) gene polymorphism and microvascular disease in systemic sclerosis. Ann Rheum Dis 2009;68:408-411
11. Wipff J, Gallier G, Dieude P, Avouac J, Tiev K, Hachulla E, et al. Angiotensin-converting enzyme gene does not contribute to genetic susceptibility to systemic sclerosis in European Caucasians. J Rheumatol 2009;36:337-340
12. Dieude P, Guedj M, Wipff J, Ruiz B, Hachulla E, Diot E, et al. STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Arthritis Rheum 2009;60:2472-2479
13. Allanore Y, Borderie D, Avouac J, Zerkak D, Meune C, Hachulla E, et al. High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis. Arthritis Rheum 2008;58:284-291
14. Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, et al. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 2000;105:1555-1562 (Pubitemid 30390306)
15. Machado RD, Koehler R, Glissmeyer E, Veal C, Suntharalingam J, Janssen B, et al. Genetic association of the serotonin transporter in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006;173:793-797