Age-related changes in bone structure and strength in female and male BALB/c Mice

Calcified Tissue International

Volumn 86, Issue 6, 2010, Pages 470-483

  Willinghamm, Mark D ^a,b   Brodt, Michael D ^a   Lee, Kristen L ^a,b   Stephens, Abby L ^a,b   Ye, Jiaxin ^b   Silva, Matthew J ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Aging; Bone mineralization; Bone strength; Bone structure; Mouse model

Indexed keywords

AGING; ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; BIOMECHANICS; BONE AGE; BONE DENSITY; BONE GROWTH; BONE STRENGTH; BONE STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; FEMALE; FEMUR; FRACTURE; FRIGIDITY; LUMBAR VERTEBRA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIUS; SEX DIFFERENCE; TIBIA; TRABECULAR BONE;

AGING; ANIMALS; BONE AND BONES; BONE DENSITY; COMPRESSIVE STRENGTH; FEMALE; MALE; MICE; MICE, INBRED BALB C; STRESS, MECHANICAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77953198416     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9359-y     Document Type: Article

References (34)

1. HG Ahlborg O Johnell CH Turner G Rannevik MK Karlsson 2003 Bone loss and bone size after menopause N Engl J Med 349 327 334 10.1056/NEJMoa022464 12878739 (Pubitemid 36886238)
2. ML Bouxsein KH Myburgh MC van der Meulen E Lindenberger R Marcus 1994 Age-related differences in cross-sectional geometry of the forearm bones in healthy women Calcif Tissue Int 54 113 118 10.1007/BF00296061 1:STN:280:DyaK2c3ot1Kntg%3D%3D 8012866
3. RB Martin PJ Atkinson 1977 Age and sex-related changes in the structure and strength of the human femoral shaft J Biomech 10 223 231 10.1016/0021-9290(77)90045-8 1:STN:280:DyaE2s7msFaktQ%3D%3D 858728
4. CB Ruff WC Hayes 1988 Sex differences in age-related remodeling of the femur and tibia J Orthop Res 6 886 896 10.1002/jor.1100060613 1:STN:280:DyaL1M%2FhtFWntg%3D%3D 3171769 (Pubitemid 18259483)
5. P Szulc E Seeman F Duboeuf E Sornay-Rendu PD Delmas 2006 Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women J Bone Miner Res 21 1856 1863 10.1359/jbmr.060904 17002580 (Pubitemid 44851561)
6. BL Riggs LJ Melton RA Robb JJ Camp EJ Atkinson JM Peterson PA Rouleau CH McCollough ML Bouxsein S Khosla 2004 Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites J Bone Miner Res 19 1945 1954 10.1359/JBMR.040916 15537436 (Pubitemid 41103408)
7. B Martin 1995 Mathematical model for repair of fatigue damage and stress fracture in osteonal bone J Orthop Res 13 309 316 10.1002/jor.1100130303 1:STN:280:DyaK2MzisF2htw%3D%3D 7602391
8. AH Burstein DT Reilly M Martens 1976 Aging of bone tissue: mechanical properties J Bone Joint Surg Am 58 82 86 1:STN:280:DyaE287itVKmtA%3D%3D 1249116
9. RW McCalden JA McGeough MB Barker CM Court-Brown 1993 Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure J Bone Joint Surg Am 75 1193 1205 1:STN:280:DyaK3szlvFCrtg%3D%3D 8354678
10. X Wang X Shen X Li CM Agrawal 2002 Age-related changes in the collagen network and toughness of bone Bone 31 1 7 10.1016/S8756-3282(01)00697-4 12110404 (Pubitemid 34754417)
11. P Zioupos JD Currey 1998 Changes in the stiffness, strength, and toughness of human cortical bone with age Bone 22 57 66 10.1016/S8756-3282(97) 00228-7 1:STN:280:DyaK1c7gtVWlug%3D%3D 9437514 (Pubitemid 28033654)
12. RW McCalden JA McGeough CM Court-Brown 1997 Age-related changes in the compressive strength of cancellous bone. The relative importance of changes in density and trabecular architecture J Bone Joint Surg Am 79 421 427 1:STN:280:DyaK2s3itl2msA%3D%3D 9070533
13. L Mosekilde L Mosekilde CC Danielson 1987 Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals Bone 8 79 85 10.1016/8756-3282(87)90074-3 1:STN:280: DyaL2s3kt1Wntg%3D%3D 3593611 (Pubitemid 17108982)
14. AC Courtney EF Wachtel ER Myers WC Hayes 1995 Age-related reductions in the strength of the femur tested in a fall-loading configuration J Bone Jt Surg Am 77 387 395 1:STN:280:DyaK2M7pslKqsw%3D%3D
15. EN Ebbesen JS Thomsen H Beck-Nielsen HJ Nepper-Rasmussen L Mosekilde 1999 Age- and gender-related differences in vertebral bone mass, density, and strength J Bone Miner Res 14 1394 1403 10.1359/jbmr.1999.14.8.1394 1:STN:280:DyaK1MzovVahsg%3D%3D 10457272 (Pubitemid 29368302)
16. EM Lochmuller M Matsuura J Bauer W Hitzl TM Link R Muller F Eckstein 2008 Site-specific deterioration of trabecular bone architecture in men and women with advancing age J Bone Miner Res 23 1964 1973 10.1359/jbmr.080709 18665791
17. Harrison DE (2009) Baseline life span data: twelve strains of commonly used laboratory mice. http://research.jax.org/faculty/harrison/ger1vi- LifeStudy2.html
18. Flurkey K, Currer JM, Harrison DE (2007) Mouse models in aging research. In: Fox JG, Barthold SW, Davisson MT et al (eds) The mouse in biomedical research, vol 3, 2nd edn. Academic Press, San Diego, pp 637-672
19. WG Beamer LR Donahue CJ Rosen DJ Baylink 1996 Genetic variability in adult bone density among inbred strains of mice Bone 18 397 403 10.1016/8756-3282(96)00047-6 1:STN:280:DyaK28zhvFWkug%3D%3D 8739896 (Pubitemid 26152301)
20. MD Brodt CB Ellis MJ Silva 1999 Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties J Bone Miner Res 14 2159 2166 10.1359/jbmr.1999.14.12.2159 1:STN:280: DC%2BD3c%2Fos1Crug%3D%3D 10620076
21. HR Buie CP Moore SK Boyd 2008 Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice J Bone Miner Res 23 2048 2059 10.1359/jbmr.080808 18684086
22. VL Ferguson RA Ayers TA Bateman SJ Simske 2003 Bone development and age-related bone loss in male C57BL/6J mice Bone 33 387 398 10.1016/S8756- 3282(03)00199-6 13678781 (Pubitemid 37107464)
23. V Glatt E Canalis L Stadmeyer ML Bouxsein 2007 Age-related changes in trabecular architecture differ in female and male C57BL/6J mice J Bone Miner Res 22 1197 1207 10.1359/jbmr.070507 17488199 (Pubitemid 351339702)
24. MJ Silva MB Brodt SL Ettner 2002 Long bones from the senescence accelerated mouse SAMP6 have increased size but reduced whole-bone strength and resistance to fracture J Bone Miner Res 17 1597 1603 10.1359/jbmr.2002.17.9.1597 12211429
25. JL Schriefer AG Robling SJ Warden AJ Fournier JJ Mason CH Turner 2005 A comparison of mechanical properties derived from multiple skeletal sites in mice J Biomech 38 467 475 10.1016/j.jbiomech.2004.04.020 15652544 (Pubitemid 40126457)
26. SM Tommasini TG Morgan M van der Meulen KJ Jepsen 2005 Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body J Bone Miner Res 20 817 827 10.1359/JBMR.041234 15824855 (Pubitemid 40571639)
27. C Price BC Herman T Lufkin HM Goldman KJ Jepsen 2005 Genetic variation in bone growth patterns defines adult mouse bone fragility J Bone Miner Res 20 1983 1991 10.1359/JBMR.050707 1:CAS:528:DC%2BD2MXht1amt7nF 16234972 (Pubitemid 41532784)
28. BP Halloran VL Ferguson SJ Simske A Burghardt LL Venton S Majumdar 2002 Changes in bone structure and mass with advancing age in the male C57BL/6J mouse J Bone Miner Res 17 1044 1050 10.1359/jbmr.2002.17.6.1044 12054159
29. MJ Silva MD Brodt B Wopenka S Thomopoulos D Williams MH Wassen M Ko N Kusano RA Bank 2006 Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse J Bone Miner Res 21 78 88 10.1359/JBMR.050909 16355276 (Pubitemid 43023229)
30. RJ Bergman D Gazit AJ Kahn H Gruber S McDougall TJ Hahn 1996 Age-related changes in osteogenic stem cells in mice J Bone Miner Res 11 568 577 10.1002/jbmr.5650110504 1:CAS:528:DyaK28XjtVGksrw%3D 9157771
31. MJ Silva MD Brodt BA Uthgenannt 2004 Morphological and mechanical properties of vertebrae in the SAMP6 mouse model of senile osteoporosis Bone 35 425 431 10.1016/j.bone.2004.03.027 15268893 (Pubitemid 38953189)
32. BL Clarke PR Ebeling JD Jones HW Wahner WM O'Fallon BL Riggs LA Fitzpatrick 1996 Changes in quantitative bone histomorphometry in aging healthy men J Clin Endocrinol Metab 81 2264 2270 10.1210/jc.81.6.2264 1:CAS:528:DyaK28XjsFyksbo%3D 8964862 (Pubitemid 26175955)
33. JD Currey K Brear P Zioupos 1996 The effects of ageing and changes in mineral content in degrading toughness of human femora J Biomech 29 257 260 10.1016/0021-9290(95)00048-8 1:STN:280:DyaK2s%2Fgt1Cktg%3D%3D 8849821 (Pubitemid 26010608)
34. Whittingham DG, Wood MJ (1983) Reproductive physiology. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, vol 3, 1st edn. Academic Press, San Diego, pp 137-164