Phaeohyphomycosis due to Alternaria species in transplant recipients

Transplant Infectious Disease

Volumn 12, Issue 3, 2010, Pages 242-250

  Boyce, R D ^a   Deziel, P J ^a   Otley, C C ^a   Wilhelm, M P ^a   Eid, A J ^a   Wengenack, N L ^a   Razonable, R R ^a  

^a MAYO CLINIC   (United States)

Author keywords

Alternaria; Caspofungin; Echinocandin; Fungal infections; Fungi; Mycoses; Phaeohyphomycosis; Posaconazole; Transplant; Voriconazole

Indexed keywords

AZATHIOPRINE; CASPOFUNGIN; CYCLOSPORIN A; ITRACONAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; POSACONAZOLE; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; VORICONAZOLE; ANTIFUNGAL AGENT; ECHINOCANDIN; PYRROLE DERIVATIVE;

ACUTE GRAFT REJECTION; ADULT; ALTERNARIA; ALTERNARIOSIS; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CHRONIC GRAFT REJECTION; CLINICAL ARTICLE; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ERYTHEMA; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; HUMAN; HUMAN TISSUE; LIVER TOXICITY; LOADING DRUG DOSE; MALE; OPPORTUNISTIC INFECTION; PAPULE; PHAEOHYPHOMYCOSIS; PHOTOSENSITIVITY; PRIORITY JOURNAL; PUSTULE; SKIN NODULE; TREATMENT OUTCOME; CLASSIFICATION; DERMATOMYCOSES; DRUG EFFECTS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; OPPORTUNISTIC INFECTIONS; ORGAN TRANSPLANTATION; PATHOLOGY;

ADULT; ALTERNARIA; ANTIFUNGAL AGENTS; AZOLES; DERMATOMYCOSES; ECHINOCANDINS; FEMALE; HUMANS; MALE; MIDDLE AGED; OPPORTUNISTIC INFECTIONS; ORGAN TRANSPLANTATION;

EID: 77953190533     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2009.00482.x     Document Type: Article

References (27)

1. Ajello L, Georg LK, Steigbigel RT, Wang CJ. A case of phaeohyphomycosis caused by a new species of Phialophora. Mycologia 1974 66 (3 490 498.
2. Gilaberte M, Bartralot R, Torres JM, et al. Cutaneous alternariosis in transplant recipients: clinicopathologic review of 9 cases. J Am Acad Dermatol 2005 52 (4 653 659.
3. Pastor FJ, Guarro J. Alternaria infections: laboratory diagnosis and relevant clinical features. Clin Microbiol Infect 2008 14 (8 734 746.
4. Lyke KE, Miller NS, Towne L, Merz WG. A case of cutaneous ulcerative alternariosis: rare association with diabetes mellitus and unusual failure of itraconazole treatment. Clin Infect Dis 2001 32 (8 1178 1187.
5. Ben-Ami R, Lewis RE, Raad II, Kontoyiannis DP. Phaeohyphomycosis in a tertiary care cancer center. Clin Infect Dis 2009 48 (8 1033 1041.
6. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008 46 (12 1813 1821.
7. Larone DH. Medically Important Fungi: A Guide to Identification (4th edn)., Washington, DC: ASM Press, 2002.
8. CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi: Approved Standard. CLSI Document M38-A., Philadelphia, PA: CLSI, 2002.
9. Kazory A, Ducloux D, Reboux G, et al. Cutaneous Alternaria infection in renal transplant recipients: a report of two cases with an unusual mode of transmission. Transpl Infect Dis 2004 6 (1 46 49.
10. Farina C, Gotti E, Parma A, Naldi L, Goglio A. Pheohyphomycotic soft tissue disease caused by Alternaria alternata in a kidney transplant patient: a case report and literature review. Transplant Proc 2007 39 (5 1655 1659.
11. Revankar SG, Patterson JE, Sutton DA, Pullen R, Rinaldi MG. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis 2002 34 (4 467 476.
12. Halaby T, Boots H, Vermeulen A, et al. Phaeohyphomycosis caused by Alternaria infectoria in a renal transplant recipient. J Clin Microbiol 2001 39 (5 1952 1955.
13. Merino E, Banuls J, Boix V, et al. Relapsing cutaneous alternariosis in a kidney transplant recipient cured with liposomal amphotericin B. Eur J Clin Microbiol Infect Dis 2003 22 (1 51 53.
14. Luque P, Garcia-Gil FA, Larraga J, et al. Treatment of cutaneous infection by Alternaria alternata with voriconazole in a liver transplant patient. Transplant Proc 2006 38 (8 2514 2515.
15. Perfect JR, Marr KA, Walsh TJ, et al. Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis 2003 36 (9 1122 1131.
16. Wildfeuer A, Seidl HP, Paule I, Haberreiter A. In vitro evaluation of voriconazole against clinical isolates of yeasts, moulds and dermatophytes in comparison with itraconazole, ketoconazole, amphotericin B and griseofulvin. Mycoses 1998 41 (7-8 309 319.
17. Cuenca-Estrella M, Gomez-Lopez A, Mellado E, Buitrago MJ, Monzon A, Rodriguez-Tudela JL. Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi. Antimicrob Agents Chemother 2006 50 (3 917 921.
18. Cuenca-Estrella M, Ruiz-Diez B, Martinez-Suarez JV, Monzon A, Rodriguez-Tudela JL. Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum. J Antimicrob Chemother 1999 43 (1 149 151.
19. McGinnis MR, Pasarell L, Sutton DA, Fothergill AW, Cooper CR Jr., Rinaldi MG. In vitro activity of voriconazole against selected fungi. Med Mycol 1998 36 (4 239 242.
20. Mullane K, Toor AA, Kalnicky C, Rodriguez T, Klein J, Stiff P. Posaconazole salvage therapy allows successful allogeneic hematopoietic stem cell transplantation in patients with refractory invasive mold infections. Transpl Infect Dis 2007 9 (2 89 96.
21. Kahn JN, Hsu MJ, Racine F, Giacobbe R, Motyl M. Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-d-1,3 glucan levels in culture. Antimicrob Agents Chemother 2006 50 (6 2214 2216.
22. Del Poeta M, Schell WA, Perfect JR. In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds. Antimicrob Agents Chemother 1997 41 (8 1835 1836.
23. Tu EY. Alternaria keratitis: clinical presentation and resolution with topical fluconazole or intrastromal voriconazole and topical caspofungin. Cornea 2009 28 (1 116 119.
24. Laumaille C, Le Gall F, Degeilh B, Gueho E, Huerre M. Cutaneous Alternaria infectoria infection after liver transplantation Ann Pathol 1998 18 (3 192 194.
25. Miele PS, Levy CS, Smith MA, et al. Primary cutaneous fungal infections in solid organ transplantation: a case series. Am J Transplant 2002 2 (7 678 683.
26. Ara M, Aspiroz C, Zaballos P, et al. Relapse of cutaneous Alternaria infectora in a renal transplant recipient after 2 years. Acta Derm Venereol 2006 86 (2 154 155.
27. Vieira R, Veloso J, Afonso A, Rodrigues A. Cutaneous alternariosis in a liver transplant recipient. Rev Iberoam Micol 2006 23 (2 107 109.