Usage of benzodiazepines: A review

International Journal of Psychiatry in Clinical Practice

Volumn 14, Issue 2, 2010, Pages 78-87

  Donoghue, John ^a,b   Lader, Malcolm ^c  

^a Medicines in Mental Health Ltd   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Benzodiazepines; Dependence problems; Long term usage; Prescriptions

Indexed keywords

ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CLORAZEPATE; DIAZEPAM; FLUNITRAZEPAM; HYPNOTIC AGENT; LORAZEPAM; NITRAZEPAM; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TEMAZEPAM; TRICYCLIC ANTIDEPRESSANT AGENT; ZOLPIDEM; ZOPICLONE;

AGE; CLINICAL PRACTICE; DRUG EFFICACY; DRUG SAFETY; DRUG USE; EUROPE; GENERALIZED ANXIETY DISORDER; HUMAN; INSOMNIA; LONG TERM CARE; MAJOR DEPRESSION; MENTAL DISEASE; NORTH AMERICA; PHARMACEUTICAL CARE; PRESCRIPTION; PREVALENCE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; REVIEW; RISK BENEFIT ANALYSIS; SLEEP DISORDER; UNITED KINGDOM;

EID: 77953189858     PISSN: 13651501     EISSN: 14711788     Source Type: Journal    
DOI: 10.3109/13651500903447810     Document Type: Review

References (59)

1. Committee on the Review of Medicines. Systematic review of benzodiazepines. Br Med J 1980;280:910-12.
2. Katzman MA. Current considerations in the treatment of Generalized Anxiety Disorder. CNS Drugs 2009;23: 103-20.
3. Lader M. Benzodiazepines. A risk-benefit profile. CNS Drugs 1994;1:377-87.
4. Barker MJ, Greenwood KM, Jackson M, et al. Cognitive effects of long-term benzodiazepine use. CNS Drugs 2004; 18:37-45.
5. Lader M. History of benzodiazepine dependence. J Substance Abuse Treatment 1991;8:1-2.
6. Ashton H. The diagnosis and management of benzodiaze-pine dependence. Curr Opin Pychiatry 2005;18:249-255.
7. Jaffe JH, Bloor R, Crome, et al. A postmarketing study of relative abuse liability of hypnotic sedative drugs. Addiction 2004;99:165-173.
8. Martin JLR, Sainz-Pardo M, Furukawa TA, et al. Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol 2007;21: 774-782.
9. Wright N, Caplan R, Payne S. Community survey of long term daytime use of benzodiazepines. Br Med J 1994; 309:27-8.
10. Ohayon MM, Caulet M, Priest RG, Guilleminault C. Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol 1998;51:273-83.
11. Siriwardena AN, Qureshi Z, Gibson S, Collier S, Latham M. GPs' attitudes to benzodiazepine and 'Z-drug' prescribing: a barrier to implementation of evidence and guidance on hypnotics. Br J Gen Pract 2006;56:964-7.
12. National Institute for Health and Clinical Excellence. Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia. Technology Appraisal 77. London, National Institute for Health and Clinical Excellence; April 2004.
13. Office of National Statistics. Psychiatric morbidity among adults living in private households, 2000. London: HMSO; 2006.
14. Colman I, Wadsworth ME, Croudace TJ, Jones PB. Three decades of antidepressant, anxiolytic and hypnotic use in a national population birth cohort. Br J Psychiatry 2006; 189:156-60.
15. Krska J, MacLeod TN. Sleep quality and the use of benzo-diazepine hypnotics in general practice. J Clin Pharmacol Ther 1995;20:91-6.
16. Pharoah PD, Meltzer D. Variation in prescribing of hypnotics and antidepressants between 61 general practices. Br J Gen Pract 1995;45:595-9.
17. Nolan L, O'Malley K. Patients, prescribing, and benzodi-azepines. Eur J Clin Pharmacol 1988;35:225-9.
18. Straand J, Rokstad K. General practitioners' prescribing patterns of benzodiazepine hypnotics: are elderly patients at particular risk for overprescribing? A report from the Møre & Romsdal Prescription Study. Scand J Prim Health Care 1997;15:16-21.
19. Lagnaoui R, Depont F, Fourrier A, Abouelfath A, Begaud B, Verdoux H, Moore N. Patterns and correlates of benzodi-azepine use in the French general population. Eur J Clin Pharmacol 2004;60:523-9.
20. Ciuna A, Andretta M, Corbari L, Levi D, Mirandola M, Sorio A, et al. Are we going to increase the use of antidepres-sants up to that of benzodiazepines? Eur J Clin Pharmacol 2004;60:629-34.
21. Veronese A, Garatti M, Cipriani A, Barbui C. Benzodiazepine use in the real world of psychiatric practice: low-dose, long-term drug taking and low rates of treatment discontinuation. Eur J Clin Pharmacol 2007;63:867-73.
22. Magrini N, Vaccheri A, Parma E, D'Alessandro R, Bottoni A, Occhionero M, et al. Use of benzodiazepines in the Italian general population: prevalence, pattern of use and risk factors for use. Eur J Clin Pharmacol 1996; 50:19-25.
23. Isacson D, Carsjo K, Bergman U, Blackburn JL. Long-term use of benzodiazepines in a Swedish community: an eight-year follow-up. J Clin Epidemiol 1992; 45:429-36.
24. van Hulten R, Teeuw KB, Bakker A, Leufkens HG. Initial 3-month usage characteristics predict long-term use of benzodiazepines: an 8-year follow-up. Eur J Clin Pharmacol 2003;58:689-94.
25. Zandstra SM, Furer JW, van de Lisdonk EH, van't HM, Bor JH, van Weel C, et al. Different study criteria affect the prevalence of benzodiazepine use. Soc Psychiatry Psychiatr Epidemiol 2002;37:139-44.
26. Zandstra SM, van Rijswijk E, Rijnders CATh, van de Lisdonk EH, Bor JHJ, van Weel C, et al. Long-term benzo-diazepine users in family practice: differences from short-term users in mental health, coping behaviour and psychological characteristics. Family Practice 2004;21:266-9.
27. Hausken AM, Furu K, Skurtveit S, Engeland A, Bramness JG. Starting insomnia treatment: the use of benzodiazepines versus z-hypnotics. A prescription database study of predictors. Eur J Clin Pharmacol 2009;65:295-301.
28. van Rijswijk E, Borghuis M, van de Lisdonk E, Zitman F, van Weel. Treatment of mental health problems in general practice: a survey of psychotropics prescribed and other treatments provided. Int J Clin Pharmacol Ther 2007; 45:23-9.
29. van Hulten R, Isacson D, Bakker A, Leufkens HG. Comparing patterns of long-term benzodiazepine use between a Dutch and a Swedish community. Pharmacoepidemiol Drug Saf 2003;12:49-53.
30. Ohayon MM, Lader MH. Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom. J Clin Psychiatry 2002;63:817-25.
31. Alsonso J, Ferrer M, Romera B, Vilagut G, et al. The European Study of the Epidemiology of Mental Misorders. ESEMeD/MHEDEA 2000; project: rationale and methods. Int J Methods Psychiatr Res 2002;11:55-6.
32. Mancini J, Thition X, Masut A, et al. Anxiolytics, hypnotics, and antidepressants dispensed to adolescents in a French region in 2002. Pharmacoepidemiol Drug Saf 2006;15: 494-503.
33. Kessler RC. The global burden of anxiety and mood disorders: putting ESEMeD findings into perspective. J Clin Psychiatr 2007;68(Suppl 2):10-19.
34. Vasile RG, Bruce SE, Goisman RM, Pagano M, Keller MB. Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in treatment of Generalized Anxiety Disorder and Social Phobia. Depress Anxiety 2005;22:59-67.
35. Neutel CI. The epidemiology of long-term benzodiazepine use. Int Rev Psychiatry 2005;17:189-97.
36. Smith AJ, Sketris I, Cooke C, et al. A comparison of benzo-diazepine and related drug use in Nova Scotia and Australia. Can J Psychiatr 2008;53:545-52.
37. Ribeiro CS, Azevedo RCS, da Silva VF, Botega NJ. Chronic use of diazepam in primary healthcare centers: user profile and usage pattern. Sao Paulo Med J 2007;125:270-4.
38. Taylor S, McCracken CF, Wilson KC, Copeland JR. Extent and appropriateness of benzodiazepine use. Results from an elderly urban community. Br J Psychiatry 1998; 173:433-8.
39. Batty GM, Osborne CA, Swift CG, Jackson SH. Development of an indicator to identify inappropriate use of benzo-diazepines in elderly medical in-patients. Int J Geriatr Psychiatry 2000;15:892-6.
40. Straand J, Rokstad KS. Elderly patients in general practice: diagnoses, drugs and inappropriate prescriptions. A report from the Møre & Romsdal Prescription Study. Family Practice 1999;16:380-8.
41. Linden M, Bär T, Helmchen H. Prevalence and appropriateness of psychotropic drug use in old age; results from the Berlin Aging Study (BASE). Int Psychogeriatr 2004;16: 461-80.
42. Luijendijk HJ, Tiermeier H, Hofman A, Heeringa J, Stricker BHCh. Determinants of chronic benzodiazepine use in the elderly: a longitudinal study. Br J Clin Pharmacol 2007; 65:593-9.
43. Aparasu RR, Mort JR, Brandt H. Psychotropic prescription use by community-dwelling elderly in the United States. J Am Geriatr Soc 2003;51:671-7.
44. Aparasu RR, Mort JR. Prevalence, correlates, and associated outcomes of potentially inappropriate psychotropic use in the community-dwelling elderly. Am J Geriatr Pharmacother 2004;2:102-11.
45. Tu K, Mamdani MM, Hux JE, Tu JB. Progressive trends in the prevalence of benzodiazepine prescribing in older people in Ontario, Canada. J Am Geriatr Soc 2001;49: 1341-5.
46. Grad R, Tamblyn R, Holbrook AM, et al. Risk of a new benzodiazepine prescription in relation to recenr hospitalization. J Am Geriatr Soc 1999;47:184-8.
47. Windle A, Elliot E, Duszynski K, Moore V. Benzodiazepine prescribing in elderly Australian general practice patients. Aust NZ J Public Health 2007;31:379-81.
48. Millar HL, Clunie FS, NcGilchrist MM, et al. The impact of community benzodiazepine prescribing of hospitalization. J Psychosom Res 1997;42:61-9.
49. Howes JB, Ryan J, Fairbrother G, O'Neill K, Howes LG. Benzodiazepine prescribing in a Sydney teaching hospital. Med J Australia 1996;165:305-8.
50. Nakao M, Takeuchi T, Yano E. Prescription of benzodi-azepines and antidepressants to outpatients attending a Japanese university hospital. International J Clin Pharmacol Ther 2007;45:30-5.
51. Valenstein M, Taylor KK, Austin K, et al. Benzodiazepine use among depressed patients treated in mental health settings. Am J Psychiatr 2004;161:654-61.
52. Hallahan BP, Murray IT, McDonald C. Benzodiazepine and hypnotic prescribing in an acute psychiatric in-patient unit. Psychiatric Bull 2009;33:12-4.
53. Holbrook AM. Editorial: treating insomnia. Br Med J 2004; 329:1198-9.
54. NHS Business Services Authority, Prescription Pricing Division http://www.ppa.org.uk//news/pact-092005.htm accessed 9.5.07.
55. National Institute for Health and Clinical Excellence. Anxiety: management of anxiety (panic disorder, with or without agoraphobia, and generalised anxiety disorder) in adults in primary, secondary and community care (December 2004) Clinical Guidance 22: National Institute for Health and Clinical Excellence.
56. Anthierens S, Habraken H, Petrovic M, Christiaens T. The lesser evil? Initiating a benzodiazepine prescription in general practice. Scand J Primary Health Care 2007;25:214-9.
57. Haw C, Stubbs J. Benzodiazepines - a necessary evil? A survey of prescribing at a specialist UK psychiatric hospital. J Psychopharmacol 2007;21:645-9.
58. Logan KE, Lawrie SM. Long term use of hypnotics and anxiolytics may not result in increased tolerance. Br Med J 1994; 309:742-3.
59. Sussman N. Treating anxiety while minimizing abuse and dependence. J Clin Psychiatry 1993;54(Suppl): 44-51.