Missing links in pressure ulcer research - An interdisciplinary overview

Journal of Applied Physiology

Volumn 108, Issue 6, 2010, Pages 1458-1464

  Olesen, Christian Gammelgaard ^a   De Zee, Mark ^a   Rasmussen, John ^a  

^a AALBORG UNIVERSITY   (Denmark)

Author keywords

Biomechanics; Deep tissue injury; Pressure ulcer; Spinal cord injury; Wheelchair

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; DECUBITUS; HUMAN; MEDICAL RESEARCH; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW; SPINAL CORD INJURY; COMPLICATION; PRESSURE ULCER; TRENDS;

ANIMALS; BIOMEDICAL RESEARCH; HUMANS; MODELS, BIOLOGICAL; PRESSURE ULCER; SPINAL CORD INJURIES;

EID: 77953165280     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01006.2009     Document Type: Review

References (60)

1. Agam L, Gefen A. Toward real-time detection of deep tissue injury risk in wheelchair users using Hertz contact theory. J Rehabil Res Dev 45: 537-550, 2008.
2. Agam L, Gefen A. Pressure ulcers and deep tissue injury: A bioengineering perspective. J Wound Care 16: 336-342, 2007.
3. Bader D, Oomens C, Bouten C, Taylor R, James T, Sanders J. Pressure Ulcer Research - Current and Future Perspectives. Berling: Springer, 2005, p. 382.
4. Bennett L, Kavner D, Lee BK, Trainor FA. Shear vs pressure as causative factors in skin blood flow occlusion. Arch Phys Med Rehabil 60: 7: 309-314, 1979.
5. Bennett L, Kavner D, Lee BY, Trainor FS, Lewis JM. Skin stress and blood flow in sitting paraplegic patients. Arch Phys Med Rehabil 65: 186-190, 1984.
6. Brem H, Lyder C. Protocol for the successful treatment of pressure ulcers. Am J Surg 188: 9-17, 2004.
7. Breuls RG, Bouten CV, Oomens CW, Bader DL, Baaijens FP. Compression induced cell damage in engineered muscle tissue: an in vitro model to study pressure ulcer aetiology. Ann Biomed Eng 31: 1357-1364, 2003.
8. Brienza DM, Karg PE, JoGeyer M, Kelsey S, Trefler E. The relationship between pressure ulcer incidence and buttock-seat cushion interface pressure in at-risk elderly wheelchair users. Arch Phys Med Rehabil 82: 529-533, 2001.
9. Brooks B. Pathologic changes in muscle as a result of disturbances of circulation: An experimental study of Volkmann's ischemic paralysis. Arch Surg 5: 188-216, 1922.
10. Bush TR, Hubbard RP. Support force measures of midsized men in seated positions. J Biomech Eng 129: 58-65, 2007.
11. Chen D, Apple DF, Jr Hudson LM, Bode R. Medical complications during acute rehabilitation following spinal cord injury-current experience of the Model Systems. Arch Phys Med Rehabil 80: 1397-1401, 1999.
12. Cho J, Kang GH, Kim EC, Oh YM, Choi HJ, Im TH, Yang JH, Cho YS, Chung HS. Comparison of manikin versus porcine models in cricothyrotomy procedure training. Emerg Med J 25: 732-734, 2008.
13. Conine TA, Hershler C, Daechsel D, Peel C, Pearson A. Pressure ulcer prophylaxis in elderly patients using polyurethane foam or Jay wheelchair cushions, Int J Rehabil Res 17: 123-137, 1994.
14. Daniel RK, Priest DL, Wheatley DC. Etiologic factors in pressure sores: an experimental model. Arch Phys Med Rehabil 62: 492-498, 1981.
15. Dansereau JG, Conway H. Closure of decubiti in paraplegics. Report of 2000 cases. Plast Reconstr Surg 33: 474-480, 1964.
16. Deitrick G, Charalel J, Bauman W, Tuckman J. Reduced arterial circulation to the legs in spinal cord injury as a cause of skin breakdown lesions. Angiology 58: 175-184, 2007.
17. Dietrick RB, Russi S. Tabulation and review of autopsy findings in fifty-five paraplegics. J Am Med Assoc 166: 41-44, 1958.
18. EPFL. Peripheral Systems Lab. Visible Human Server [Online], http:// visiblehuman.epfl.ch/[04/03/2009 2009].
19. Gawlitta D, Li W, Oomens CW, Baaijens FP, Bader DL, Bouten CV. The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study. Ann Biomed Eng 35: 273-284, 2007.
20. Gawlitta D, Oomens CW, Bader DL, Baaijens FP, Bouten CV. Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle. J Appl Physiol 103: 464-473, 2007.
21. Gefen A. Risk factors for a pressure-related deep tissue injury: A theoretical model. Med Biol Eng Comput 45: 563-573, 2007.
22. Gefen A, Gefen N, Linder-Ganz E, Margulies SS. In vivo muscle stiffening under bone compression promotes deep pressure sores. J Biomech Eng 127: 512-524, 2005.
23. Gefen A, van Nierop B, Bader DL, Oomens CW. Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury. J Biomech 41: 2003-2012, 2008.
24. Giangregorio L, McCartney N. Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies. J Spinal Cord Med 29: 489-500, 2006.
25. Gilsdorf P, Patterson R, Fisher S. Thirty-minute continuous sitting force measurements with different support surfaces in the spinal cord injured and able-bodied. J Rehabil Res Dev 28: 33-38, 1991.
26. Gilsdorf P, Patterson R, Fisher S, Appel N. Sitting forces and wheelchair mechanics. J Rehabil, Res Dev 27: 239-246, 1990.
27. Goossens RH, Snijders CJ, Holscher TG, Heerens WC, Holman AE. Shear stress measured on beds and wheelchairs. Scand J Rehabil Med 29: 131-136, 1997.
28. Goossens RH, Zegers R, Hoek van Dijke GA, Snijders CJ. Influence of shear on skin oxygen tension. Clin Physiol 14: 111-118, 1994.
29. Hobson DA. Comparative effects of posture on pressure and shear at the body-seat interface. J Rehabil Res Dev 29: 21-31, 1992.
30. Husain T. An experimental study of some pressure effects on tissues, with reference to the bed-sore problem. J Pathol Bacteriol 66: 347-358, 1953.
31. Kosiak M. Etiology of decubitus ulcers. Arch Phys Med Rehabil 42: 19-29, 1961.
32. Kosiak M. Etiology and pathology of ischemic ulcers. Arch Phys Med Rehabil 40: 62-69, 1959.
33. Kosiak M, Kubicek WG, Olson M, Danz JN, Kottke FJ. Evaluation of pressure as a factor in the production of ischial ulcers. Arch Phys Med Rehabil 39: 10: 623-629, 1958.
34. Lapsley HM, Vogels R. Cost and prevention of pressure ulcers in an acute teaching hospital. Int J Qual Health Care 8: 61-66, 1996.
35. Linder-Ganz E, Engelberg S, Scheinowitz M, Gefen A. Pressure-time cell death threshold for albino rat skeletal muscles as related to pressure sore biomechanics. J Biomech 39: 2725-2732, 2006.
36. Linder-Ganz E, Gefen A. Stress analyses coupled with damage laws to determine biomechanical risk factors for deep tissue injury during sitting. J Biomech Eng 131: 011003, 2009.
37. Linder-Ganz E, Gefen A. Mechanical compression-induced pressure sores in rat hindlimb: muscle stiffness, histology, and computational models. J Appl Physiol 96: 2034-2049, 2004.
38. Linder-Ganz E, Shabshin N, Itzchak Y, Gefen A. Assessment of mechanical conditions in sub-dermal tissues during sitting: A combined experimental-MRI and finite element approach. J Biomech 40: 1443-1454, 2007.
39. Linder-Ganz E, Shabshin N, Itzchak Y, Yizhar Z, Siev-Ner I, Gefen A. Strains and stresses in sub-dermal tissues of the buttocks are greater in paraplegics than in healthy during sitting. J Biomech 41: 567-580, 2008.
40. Linder-Ganz E, Yarnitzky G, Yizhar Z, Siev-Ner I, Gefen A. Real-time finite element monitoring of sub-dermal tissue stresses in individuals with spinal cord injury: toward prevention of pressure ulcers. Ann Biomed Eng 37: 387-400, 2009.
41. Maurer CL, Sprigle S. Effect of seat inclination on seated pressures of individuals with spinal cord injury. Phys Ther 84: 255-261, 2004.
42. Meijer JH, Germs PH, Schneider H, Ribbe MW. Susceptibility to decubitus ulcer formation. Arch Phys Med Rehabil 75: 318-323, 1994.
43. Nola GT, Vistnes LM. Differential response of skin and muscle in the experimental production of pressure sores. Plast Reconstr Surg 66: 5: 728-733, 1980.
44. Peeters EAG, Bouten CVC, Oomens CWJ, Baaijens FPT. Monitoring the biomechanical response of individual cells under compression: A new compression device. Med Biol Eng Comput 41: 498-503, 2003.
45. Peirce SM, Skalak TC, Rodeheaver GT. Ischemia-reperfusion injury in chronic pressure ulcer formation: A skin model in the rat. Wound Repair Regen 8: 68-76, 2000.
46. Salzberg CA, Byrne DW, Cayten CG, van Niewerburgh P, Murphy JG, Viehbeck M. A new pressure ulcer risk assessment scale for individuals with spinal cord injury. Am J Phys Med Rehabil 75: 96-104, 1996.
47. Shields RK, Cook TM. Effect of seat angle and lumbar support on seated buttock pressure. Phys Ther 68: 1682-1686, 1988.
48. Shirado O, Kawase M, Minami A, Strax TE. Quantitative evaluation of long sitting in paraplegic patients with spinal cord injury. Arch Phys Med Rehabil 85: 1251-1256, 2004.
49. Siefert A, Pankokea S, Wölfela H. Virtual optimisation of car passenger seats: Simulation of static and dynamic effects on drivers' seating comfort. Int J Ind Ergonomics 38: 410, 2008.
50. Slomka N, Or-Tzadikario S, Sassun D, Gefen A. Membrane-stretchinduced cell death in deep tissue injury: computer model studies. Cell Mol Bioeng; doi: 10.1007/s12195-009-0046-x.
51. Stekelenburg A, Oomens CW, Strijkers GJ, Nicolay K, Bader DL. Compression-induced deep tissue injury examined with magnetic resonance imaging and histology. J Appl Physiol 100: 1946-1954, 2006.
52. Then C, Menger J, Benderoth G, Alizadeh M, Vogl TJ, Hubner F, Silber G. Analysis of mechanical interaction between human gluteal soft tissue and body supports. Technol Health Care 16: 61-76, 2008.
53. Thorfinn J, Sjöberg F, Lidman D. Perfusion of buttock skin in healthy volunteers after long and short repetitive loading evaluated by laser Doppler perfusion imager. Scand J Plast Reconstr Surg Hand Surg 41: 297-302, 2007.
54. Todd BA, Thacker JG. Three-dimensional computer model of the human buttocks, in vivo. J Rehabil Res Dev 31: 111-119, 1994.
55. Tsuji S, Ichioka S, Sekiya N, Nakatsuka T. Analysis of ischemiareperfusion injury in a microcirculatory model of pressure ulcers. Wound Repair Regen 13: 209-215, 2005.
56. van Geffen P, Reenalda J, Veltink PH, Koopman BF. Effects of sagittal postural adjustments on seat reaction load. J Biomech 41: 2237-2245, 2008.
57. Verver MM, van Hoof J, Oomens CW, Wismans JS, Baaijens FP. A finite element model of the human buttocks for prediction of seat pressure distributions. Comput Methods Biomech Biomed Engin 7: 193-203, 2004.
58. Visible Human Server.
59. Wagnac EL, Aubin C, Dansereau J. A new method to generate a patient-specific finite element model of the human buttocks. IEEE Trans Biomed Eng 55: 774-783, 2008.
60. Zhang M, Roberts VC. The effect of shear forces externally applied to skin surface on underlying tissues. J Biomed Eng 15: 451-456, 1993.