The effects of loading and estrogen on rat bone growth

Journal of Applied Physiology

Volumn 108, Issue 6, 2010, Pages 1737-1744

  Leppänen, Olli V ^a,b   Sievänen, Harri ^c   Jokihaara, Jarkko ^a,b,d   Pajamäki, Ilari ^a,b   Kannus, Pekka ^a,b,c   Cooper, David M ^e   Järvinen, Teppo L N ^a,b,d  

^a UNIVERSITY OF TAMPERE   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UKK INSTITUTE FOR HEALTH PROMOTION RESEARCH   (Finland)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Bone mass; Bone strength; Development; Femur; Peripheral quantitative computed tomography

Indexed keywords

ESTROGEN;

ANIMAL; BONE DEVELOPMENT; DRUG EFFECTS; FEMALE; FEMUR; GROWTH, DEVELOPMENT AND AGING; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; WEIGHT BEARING;

ANIMALS; BONE DEVELOPMENT; ESTROGENS; FEMALE; FEMUR; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT-BEARING;

EID: 77953154883     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00989.2009     Document Type: Article

References (52)

1. Baron R. FSH versus estrogen: who's guilty of breaking bones? Cell Metab 3: 302-305, 2006.
2. Biewener AA, Bertram JE. Structural response of growing bone to exercise and disuse. J Appl Physiol. 76: 946-955, 1994.
3. Brouwers JE, Lambers FM, van Rietbergen B, Ito K, Huiskes R. Comparison of bone loss induced by ovariectomy and neurectomy in rats analyzed by in vivo micro-CT. J Orthop Res 27: 1521-1527, 2009.
4. Carter DR, Van Der Meulen MC, Beaupre GS. Mechanical factors in bone growth, and development. Bone 18: 5S-10S, 1996.
5. DeSantis DT, Schmaltz LW. The mother-litter relationship in developmental rat studies: cannibalism, vs. caring. Dev Psychobiol 17: 255-262, 1984.
6. Eliasson P, Fahlgren A, Pasternak B, Aspenberg P. Unloaded rat Achilles tendons continue to grow, but lose viscoelasticity. J Appl Physiol 103: 459-463, 2007.
7. Frost HM. Bone "mass" and the "mechanostat": A proposal. Anat Rec 2.19: 1-9, 1987.
8. Gomez C, David V, Peet NM, Vico L, Chenu C, Malaval L, Skerry TM. Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice. J Anat 2.10: 259-271, 2007.
9. Helander HF, Bergh A. How to avoid maternal cannibalism after neonatal surgery in rats. Experientia 36: 1295-1296, 1980.
10. Iwamoto J, Seki A, Takeda T, Sato Y, Yamada H. Effects of risedronate on femoral bone mineral density and bone strength in sciatic neurectomized young rats. J Bone Miner Metab 23: 456-462, 2005.
11. Iwasaki-Ishizuka Y, Yamato H, Murayama H, Ezawa I, Kurokawa K, Fukagawa M. Menatetrenone rescues bone loss by improving osteoblast dysfunction in. rats immobilized by sciatic neurectomy, life Sci 76: 1721-1734, 2005.
12. Jarvinen TL, Kannus P, Pajamaki I, Vuohelainen T, Tuukkanen J, Jarvinen M, Sievanen H. Estrogen deposits extra mineral into bones of female rats in puberty, but simultaneously seems to suppress the responsiveness of female skeleton, to mechanical loading. Bone 32: 642-651, 2003.
13. Jarvinen TL, Kannus P, Sievanen H. Estrogen and bone-a reproductive and locomotive perspective. J Bone Miner Res 18: 1921-1931, 2003.
14. Jarvinen TL, Kannus P, Sievanen H, Jozsa L, Heinonen OJ, Vieno T, Jarvinen M. Effects of remobilization on rat femur are dose-dependent. Scand J Med Sci Sports 11: 292-298, 2001.
15. Jarvinen TL, Pajamaki I, Sievanen H, Vuohelainen T, Tuukkanen J, Jarvinen M, Kannus P. Femoral neck response to exercise and subsequent deconditioning in young and adult rats. J Bone Miner Res 18: 1292-1299, 2003.
16. Jarvinen TL, Sievanen H, Jokihaara J, Einhorn TA. Revival of bone strength: The bottom line. J Bone Miner Res 20: 717-720, 2005.
17. Jarvinen TL, Sievanen H, Kannus P, Jarvinen M. Dual-energy X-ray absorptiometry in predicting mechanical characteristics of rat femur. Bone 22: 551-558, 1998.
18. Jiang SD, Shen C, Jiang LS, Dai LY. Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy. Osteoporos Int 18: 743-750, 2007.
19. Kalu DN. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology 115: 507-512, 1984.
20. Kim BT, Mosekilde L, Duan Y, Zhang XZ, Tornvig L, Thomsen JS, Seeman E. The structural and hormonal basis of sex differences in peak appendicular bone strength in rats. J Bone Miner Res 18: 150-155, 2003.
21. Kontulainen SA, Macdonald HM, Khan KM, McKay HA. Examining bone surfaces across puberty: A 20-mo pQCT trial. J Bone Miner Res 20: 1202-1207, 2005.
22. Lanham SA, Roberts C, Cooper C, Oreffo RO. Intrauterine programming of bone. 1. Alteration of the osteogenic environment. Osteoporos Int 19: 147-156, 2008.
23. Lanham SA, Roberts C, Perry MJ, Cooper C, Oreffo RO. Intrauterine programming of bone. 2. Alteration of skeletal structure. Osteoporos Int 19: 157-167, 2008.
24. Lanyon L, Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: A hypothesis. J Bone Miner Res 16: .1937-1947, 2001.
25. Lanyon LE. The influence of function on the development of bone curvature. An experimental study on the rat tibia. J Zool Lond 192: 457-466, 1980.
26. Lanyon LE, Baggott DG. Mechanical function as an influence on the structure and form of bone. J Bone Joint Surg Br 58-B: 436-443, 1976.
27. Leppanen O, Sievanen H, Jokihaara J, Pajamaki I, Jarvinen TL. Three-point bending of rat femur in the mediolateral direction: introduction, and validation of a novel biomechanical testing protocol. J Bone Miner Res 21: 1231-1237, 2006.
28. Leppanen OV, Sievanen H, Jarvinen TL. Biomechanical testing in experimental bone interventions-May the power be with you. J Biomech 4.1: 1623-1631, 2008.
29. Leppanen OV, Sievanen H, Jokihaara J, Pajamaki I, Kannus P, Jarvinen TL. Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit. PLoS ONE 3: e2540, 2008.
30. Lindsay R. Hormones and bone health in postmenopausal women. Endocrine 24: 223-230, 2004.
31. Pajamaki I, Kannus P, Vuohelainen T, Sievanen H, Tuukkanen J, Jarvinen M, Jarvinen TL. The bone gain induced by exercise in puberty is not preserved through a virtually life-long deconditioning: A randomized controlled experimental study in male rats. J Bone Miner Res 18: 544552, 2003.
32. Pajamaki I, Sievanen H, Kannus P, Jokihaara J, Vuohelainen T, Jarvinen TL. Skeletal effects of estrogen and mechanical loading are structurally distinct. Bone 43: 748-757, 2008.
33. Palacios J, Rodriguez JI, Ruiz A, Sanchez M, Alvarez 1, DeMiguel E. Long bone development in extrinsic fetal akinesia: an experimental study in rat fetuses subjected to oligohydramnios. Teratology 46: 79-84, 1992.
34. Rauch F. Bone growth in length and width: The Yin and Yang of bone stability. J Musculoskelet Neuronal Interact 5: 194-201, 2005.
35. Rodriguez JI, Palacios J, Ruiz A, Sanchez M, Alvarez I, Demiguel E. Morphological changes in long bone development in fetal akinesia deformation sequence: an experimental study in curarized rat fetuses. Teratology 45: 213-221, 1992.
36. Rot-Nikcevic 1, Reddy T, Downing KJ, Belliveau AC, Hallgrimsson B, Hall BK, Kablar B. Myf5-/-:MyoD-/- amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis. Dev Genes Evol 2.16: 1-9, 2006.
37. Schoenau E, Fricke O, Rauch F. The regulation of bone development as a biological system. Homo 54: 113-118, 2003.
38. Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass. Cell 125: 247-260, 2006.
39. Thompson DW. On Growth and Form. Cambridge, UK: University Press, 1919.
40. Turner RT, Backup P, Sherman PJ, Hill E, Evans GL, Spelsberg TC. Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation, and activity. Endocrinology 131: 883-889, 1992.
41. Turner RT, Hannon KS, Demers LM, Buchanan J, Bell NH. Differential effects of gonadal function on bone histomorphometry in male and female rats. J Bone Miner Res 4: 557-563, 1989.
42. Turner RT, Wakley GK, Hannon KS, Bell NH. Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Miner Res 2: 449-456, 1987.
43. Turner RT, Vandersteenhoven JJ, Bell NH. The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 2: 115-122, 1987.
44. Tuukkanen J, Wallmark B, Jalovaara P, Takala T, Sjogren S, Vaananen K. Changes induced in growing rat bone by immobilization and remobilization. Bone 12: 113-118, 1991.
45. van der Meulen MC, Carter DR. Developmental mechanics determine long bone allometry. J Theor Biol 172: 323-327, 1995.
46. Waynforth HB. Experimental and Surgical Techniques in the Rat. San Diego, CA: Academic, 1988.
47. Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirchwild, 1892.
48. Wong MY, Day NE, Luan JA, Chan KP, Wareham NJ. The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 32: 51-57, 2003.
49. Wronski TJ, Schenck PA, Cintron M, Walsh CC. Effect of body weight on osteopenia in ovariectomized rats. Calcif Tissue Int 40: 155-159, 1987.
50. Yang RS, Chen YZ, Huang TH, Tang CH, Fu WM, Lu BY, Lin WL. The effects of low-intensity ultrasound on growing bone after sciatic neurectomy. Ultrasound Med Biol 31: 431-437, 2005.
51. Yonezu H, Takata S, Shibata A. Effects of unilateral sciatic neurectomy on growing rat femur as assessed by peripheral quantitative computed tomography, Fourier transform, infrared spectroscopy and bending test. J Med Invest 5.1: 96-102, 2004.
52. Zeng QQ, Jee WS, Bigornia AE, King JG Jr, D'Souza SM, Li XJ, Ma YF, Wechter WJ. Time responses of cancellous and cortical bones to sciatic neurectomy in growing female rats. Bone 19: 13-21, 1996.