Atypical antipsychotic medications are independently associated with severe obstructive sleep apnea

Clinical Neuropharmacology

Volumn 33, Issue 3, 2010, Pages 109-113

  Rishi, Muhammad Adeel ^a   Shetty, Mahesh ^a   Wolff, Armand ^a   Amoateng Adjepong, Yaw ^a   Manthous, Constantine A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotic; Polysomnography; Sleep apnea

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; CLOZAPINE; OLANZAPINE; PALIPERIDONE; QUETIAPINE; RISPERIDONE; TRANQUILIZER; ZIPRASIDONE;

ADULT; ANTHROPOMETRIC PARAMETERS; APNEA HYPOPNEA INDEX; APNEA INDEX; ARTICLE; BIPOLAR DISORDER; BODY MASS; CENTRAL APNEA INDEX; CONTROLLED STUDY; DEPRESSION; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; EPWORTH SLEEPINESS SCALE; FEMALE; HUMAN; LARYNGEAL NERVE; MAJOR CLINICAL STUDY; MALE; NECK CIRCUMFERENCE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PSYCHOSIS; REM SLEEP; SCHIZOPHRENIA; SLEEP APNEA SYNDROME; TIC;

ADULT; AGING; ANTIPSYCHOTIC AGENTS; BODY MASS INDEX; BODY SIZE; COHORT STUDIES; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; NECK; POLYSOMNOGRAPHY; PSYCHOTIC DISORDERS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; SLEEP APNEA, OBSTRUCTIVE; SLEEP DISORDERS;

EID: 77953145932     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNF.0b013e3181db8040     Document Type: Article

References (42)

1. Allison DB, Mentore JL, Heo M, et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 1999;156:1686-1696.
2. Stanton JM. Weight gain associated with neuroleptic medication: a review. Schizophr Bull 1995;121:463-472.
3. Green AI, Patel JK, Goisman RM, et al. Weight gain from novel antipsychotic drugs: need for action. Gen Hosp Psychiatry 2000;22:224-235.
4. Wirshing DA, Pierre JM, Wirshing WC. Sleep apnea associated with antipsychotic-induced obesity. J Clin Psychiatry 2002;63:369-370.
5. Busetto L, Calo E, Mazza M, et al. Upper airway size is related to obesity and body fat distribution in women. Eur Arch Otorhinolaryngol 2009;266(4):559-563.
6. Patil SP, Schneider H, Marx JJ, et al. Neuromechanical control of upper airway patency during sleep. J Appl Physiol 2007;102:510-512.
7. Remmers JE, DeGroot WJ, Sauerland EK, et al. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 1978;44:931-938.
8. Tsuiki S, Isono S, Ishikawa T, et al. Anatomical balance of the upper airway and obstructive sleep apnea. Anesthesiology 2008;108(6):1009-1015.
9. Lunteren E, Dick TE. Motor unit regulation of mammalian pharyngeal dilator muscle activity. J Clin Invest 1989;84(2):577-585.
10. Jibson MD, Tandon R. An overview of antipsychotic medications. CNS News Special Edition 2001;3:49-547.
11. Norton JR, Ward DS, Karan S, et al. Differences between midazolam and propofol sedation on upper airway collapsibility using dynamic negative airway pressure. Anesthesiology 2006;104:1155-1164.
12. Yaddanapudi S, Batra YK, Balagopal A, et al. Sedation in patients above 60 years of age undergoing urological surgery under spinal anesthesia: comparison of propofol and midazolam infusions. J Postgrad Med 2007;53:171-175.
13. Iber C, Ancoli-Israel S, Chesson AL, et al. The AASM Manual for the Scoring of Sleep and Associated Events. West Chester, IL: American Academy of Sleep Medicine; 2007.
14. Bixler EO, Vgontzas AN, Ten Have T, et al. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998:157: 144-148.
15. Young T, Peppard PE, Gottlieb DJ, et al. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-1239.
16. Quintana-Gallego E, Carmona-Bernal C, Capote F, et al. Gender differences in obstructive sleep apnea syndrome: a clinical study of 1166 patients. Respir Med 2004;98:984-989.
17. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-1235.
18. Hoffstein V, Mateika S. Differences in abdominal and neck circumferences in patients with and without obstructive sleep apnea. Eur Respir J 1992;5:377-381.
19. Goldberg AN, Schwab RJ. Identifying the patient with sleep apnea: upper airway assessment and physical examination. Otolaryngol Clin North Am 1998;31:919-930.
20. Owens RL, Eckert DJ, Yeh SY, et al. Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature. Curr Opin Pulm Med 2008;14(6):519-524.
21. Malhoutra A, Pillar G, Fogel RB, et al. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med 2002;165:71-77.
22. Eastwood PR, Szollosi I, Platt PR, et al. Collapsibility of the upper airway during anesthesia with isoflurane. Anesthesiology 2002;97:786-793.
23. Mutoh T, Kanamaru A, Kojima K, et al. Effects of volatile anesthetics on the activity of laryngeal drive receptors in anesthetized dogs. J Vet Med Sci 1999;61:1033-1038.
24. Nishino T, Anderson JW, Sant'Ambrogio G. Effects of halothane, enflurane, and isoflurane on laryngeal receptors in dogs. Respir Physiol 1993;91:247-260. (Pubitemid 23083405)
25. McGinley BM, Schwartz AR, Schneider H, et al. Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea. J Appl Physiol 2008;105:197-205.
26. Berry RB, Bower J, Prosise G, et al. Triazolam in patients with obstructive sleep apnea. Am J Respir Crit Care Med 1995;151:450-454.
27. Cirignotta F, Mondini S, Zucconi M, et al. Zolpidem-polysomnographic study of the effect of a new hypnotic drug in sleep apnea syndrome. Pharmacol Biochem Behav 1988;29:807-809.
28. Gothelf D, Falk B, Singer P, et al. Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine. Am J Psychiatry 2002;159:1055-1057.
29. Graham KA, Perkins DO, Edwards LJ, et al. Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis. Am J Psychiatry 2005;162:118-123.
30. Antai-Otong D. Metabolic effects associated with atypical antipsychotic medications. Perspect Psychiatr Care 2004;40:70-72.
31. Fleischman JK, Ananthamoorthy R, Greenberg H, et al. An unexplained death in the psychiatric emergency room: a case of undiagnosed obstructive sleep apnea? Gen Hosp Psychiatry 2008;30:83-86.
32. Roth T, Roehrs T, Zorick F, et al. Pharmacological effects of sedative-hypnotics, narcotic analgesics, and alcohol during sleep. Med Clin North Am 1985;69:1281-1288.
33. Freudenmann RW, Süssmuth SD, Wolf RC, et al. Respiratory dysfunction in sleep apnea associated with quetiapine. Pharmacopsychiatry 2008;41:119-121.
34. Cohrs S. Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics. CNS Drugs 2008;22:939-962.
35. Winkelman JW. Schizophrenia, obesity, and obstructive sleep apnea. J Clin Psychiatry 2001;62:8-11.
36. Karanti A, Landén M. Treatment refractory psychosis remitted upon treatment with continuous positive airway pressure: a case report. Psychopharmacol Bull 2007;40:113-117.
37. Bottlender R, Möller HJ. Negative symptoms due tosleep apnea syndrome in a patient with a delusional disorder. Eur Psychiatry 1999;14:352.
38. Fountoulakis KN, Nimatoudis I, Iacovides A, et al. Off-label indications for atypical antipsychotics: a systematic review. Ann Gen Hosp Psychiatry 2004;3(1):4.
39. Young T, Shahar E, Nieto J, et al. Sleep Heart Health Study Research Group. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 2002;162:893-900.
40. Li HY, Lee LA. Sleep-disordered breathing in children. Chang Gung Med J 2009;32(3):247-257.
41. Dyken ME, Im KB. Obstructive sleep apnea and stroke. Chest 2009;136(6):1668-1677.
42. Kapur VK, Koepsell TD, deMaine J, et al. Association of hypothyroidism and obstructive sleep apnea. Am J Respir Crit Care Med 1998;158 (5 pt 1):1379-1383.