Safety of azathioprine therapy adjusted to thiopurine methyltransferase activity in the treatment of infantile atopic dermatitis. Report on 7 cases;Seguridad de azatioprina según los niveles de tiopurina metiltransferasa en el tratamiento de la dermatitis atópica infantil. Experiencia en 7 casos

Actas Dermo-Sifiliograficas

Volumn 101, Issue 5, 2010, Pages 417-422

  Martel, R M ^a   Melwani, P ^a   Islas, D ^a   Peate, Y ^a   Borrego, L ^a  

^a HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

Author keywords

Atopic dermatitis; Azathioprine; Thiopurine methyltransferase

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN A; PIMECROLIMUS; TACROLIMUS; THIOPURINE METHYLTRANSFERASE;

ADOLESCENT; AGRANULOCYTOSIS; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ATOPIC DERMATITIS; BONE MARROW SUPPRESSION; CHILD; CLINICAL ARTICLE; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LEUKOCYTE COUNT; LEUKOPENIA; LIVER TOXICITY; LYMPHOMA; MALE; NEUTROPENIA; PANCYTOPENIA; SIDE EFFECT; SPAIN; SQUAMOUS CELL CARCINOMA; TERATOGENICITY; TREATMENT DURATION;

EID: 77953142560     PISSN: 00017310     EISSN: 15782190     Source Type: Journal    
DOI: 10.1016/j.ad.2009.12.017     Document Type: Article

References (20)

1. A. Conde-Toboada, F.J. Gonzlez Barcala, and J. Toribio Dermatitis atpica infantil: revisin y actualizacin Actas Dermosifilogr 99 2008 690 700
2. S.J. Meggitt, and N.J. Reynolds Azathioprine for atopic dermatitis Review Clin Exp Dermatol 26 2001 369 375
3. L.A. Murphy, and D. Atherton A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at risk of myelosuppression Br J Dermatol 147 2002 308 315
4. J.L. Snow, and L.E. Gibson The role of genetic variation in thiopurine methyltransferasa activity and the efficacy and/or side effects of Azathioprine therapy in dermatologic patients Arch Dermatol 131 1995 193 197
5. J.I. Harper, I. Ahmed, G. Barclay, M. Lacour, P. Hoeger, and M.J. Cork Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy Br J Dermatol 142 2000 52 58
6. J. Schmitt, N. Schmitt, and M. Meurer Cyclosporin in the treatment of patients with atopic eczema a systematic review and meta-analysis JEADV 21 2007 606 619
7. K.L.E. Hon, G. Ching, T.F. Leung, C.M. Chow, K.C. Lee, and P. Cheung Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults J Derm Treat 27 2008 1 5
8. M. Heller, H.T. Shin, S.J. Orlow, and J.V. Schaffer Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients Br J Dermatol 157 2007 127 132
9. T.H. Clayton, S.M. Clark, D. Turner, and V. Goulden The treatment of severe atopic dermatitis in childhood with narrowband ultraviolet B phototherapy Clin Exp Dermatol 32 2007 28 33
10. M.P. Sheehan, D.J. Atherton, P. Norris, and J. Hawk Oral psoralen photochemotherapy in severe childhood atopic eczema: an update Br J Dermatol 129 1993 431 436
11. A. Pasić, R. Ceović, J. Lipozencić, K. Husar, S.M. Susić, and M. Skerlev Phototherapy in pediatric patients Pediatr Dermatol 20 2003 71 73
12. S. Jolles A review of high dose intravenous immunoglobulin treatment for atopic dermatitis Clin Exp Dermatol 27 2002 3 7
13. H. Kimata High dose gammaglobuline treatment for atopic dermatitis Arch Dis Child 70 1994 335 336
14. J.E. Lane, J.M. Cheyney, T.N. Lane, D.E. Kent, and D.J. Cohen Treatment of recalcitrant dermatitis with omalizumab J Am Acad Dermatol 54 2006 68 72
15. K. Wolf, L. Goldsmith, S.I. Katz, B.A. Gilchrest, A.S. Paller, and D.J. Leffell Fitzpatrick's Dermatology in General Medicine 7th ed 2008 McCraw-Hill New York
16. S.E. Wolverton Comprehensive dermatologic drug therapy 2nd ed 2008 Elsevier Indianapolis
17. B.B. Tan, J.T. Lear, D.J. Gawkrodger, and J.S. English Azathioprine in Dermatology: a survey of current practice in the UK Br J Dermatol 136 1997 351 355
18. L.A. Murphy, and D.J. Atherton Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency Pediatr Dermatol 6 2003 531 534
19. S.J. Meggitt, C. Gray, and N.J. Reynolds Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind randomised controlled trial Lancet 367 2006 839 846
20. D.A. Bucley, P. Baldwin, and S. Rogers The use of azathioprine in severe adult atopic eczema J Eur Acad Dermatol Venereol 11 1998 137 140