Biological and molecular characteristics of live attenuated Japanese encephalitis vaccine virus strain SA14-14-2 inoculated intrathoracically to culex tritaeniorhynchus

Chinese Journal of Biologicals

Volumn 20, Issue 6, 2007, Pages 419-421

  Liu, Zhi Wen ^a   Yu, Yong Xin ^b   Zhang, Hai Lin ^b  

^a NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^b NONE

Author keywords

Biological characteristic; Culex tritaeniorhynchus; Japanese encephalitis; Molecular characteristic; SA14 14 2 strain

Indexed keywords

ASPARTIC ACID; GLYCINE; JAPANESE ENCEPHALITIS VACCINE; LIVE VACCINE; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN BHK; CENTRIFUGATION; CONTROLLED STUDY; CULEX; CULEX TRITAENIORHYNCUS; DRUG ADMINISTRATION ROUTE; DRUG SAFETY; DRUG SCREENING; DRUG STABILITY; ENCEPHALITIS VIRUS; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; INOCULATION; INTRATHORACIC DRUG ADMINISTRATION; LD 50; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; TOXICITY TESTING; VIRUS STRAIN; VIRUS VIRULENCE;

CULEX TRITAENIORHYNCHUS; JAPANESE ENCEPHALITIS VIRUS; MUS;

EID: 77953136487     PISSN: 10045503     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Chinese source.
2. Chinese source.
3. Chinese source.
4. Chinese source.
5. Chinese source.
6. Monath TP, Soike K, Levenbook, et al. Recombinant, chimeric live, attenuated vaccine(ChimeriVax™) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever(17D) virus is safe, immunogenic and protective in non-human primates. Vaccine, 1999, 17 (15-16): 1869-1882.
7. Ni HL, Gwong-Jen Chang, Xie H, et al. Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14. J Gen Virol, 1995, 76(Pt 2): 409-413.