Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via c-src/MAPK/AP-1 signaling pathways

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 6, 2010, Pages 582-592

  Amos, Samson ^a   Redpath, Gerard T ^a   Dipierro, Charles G ^a   Carpenter, Joan E ^a   Hussaini, Isa M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Epidermal growth factor receptor; Glioblastoma; Invasion; Signaling molecules; Urokinase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR AP 1; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENESIS; CONTROLLED STUDY; GENE MUTATION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ASTROCYTES; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; GLIOBLASTOMA; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAP KINASE SIGNALING SYSTEM; MICE; PROMOTER REGIONS, GENETIC; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 77953136445     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181e008fe     Document Type: Article

References (36)

1. Kleihues P, Burger PC, Aldape KD, et al. Glioblastoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumors of the Central Nervous System. Lyon, France: IARC Press; 2007: 33-49
2. Behin A, Hoang-Xuan K, Carpentier AF, et al. Primary brain tumors in adults. Lancet 2003;361:323-31
3. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96
4. Smith JS, Tachibana I, Passe SM, et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glio-blastoma multiforme. J Natl Cancer Inst 2001;93:1246-56
5. Nathoo N, Goldlust S, Vogelbaum MA. Epidermal growth factor receptor antagonists: Novel therapy for the treatment of high-grade gliomas. Neurosurgery 2004;54:1480-88
6. Ekstrand AJ, Sugawa N, James CD, et al. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails. Proc Natl Acad Sci USA 1992;89:4309-13
7. Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 1992;89:2965-69
8. Chu CT, Everiss KD, Wikstrand CJ, et al. Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem J 1997;324:855-61
9. Wikstrand CJ, Reist CJ, Archer GE, et al. The class III variant of the epidermal growth factor receptor (EGFRvIII): Characterization and utilization as an immunotherapeutic target. Neurovirol 1998;4:148-58
10. Nishikawa R, Ji XD, Harmon RC, et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorige-nicity. Proc Natl Acad Sci USA 1994;91:7727-31
11. Andreasen PA, KjLller L, Christensen L, et al. The urokinase-type plas-minogen activator system in cancer metastasis: A review. Int J Cancer 1997;72:1-22
12. Gondi CS, Lakka SS, Dinh DH, et al. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits in-tracranial tumor growth in nude mice. Clin Cancer Res 2007;13:4051-60
13. Bindal AK, Hammoud M, Shi WM, et al. Prognostic significance of proteolytic enzymes in human brain tumors. J Neurooncol 1994;22:101-10
14. Gladson CL, Pijuan-Thompson V, Olman MA, et al. Up-regulation of urokinase and urokinase receptor genes in malignant astrocytoma. Am J Pathol 1995;146:1150-60
15. Yamamoto M, Sawaya R, Mohanam S, et al. Expression and localization of urokinase-type plasminogen activator receptor in human gliomas. Cancer Res 1994;54:5016-20
16. Zhao Y, Lyons CE Jr, Xiao A, et al. Urokinase directly activates matrix metalloproteinases-9: A potential role in glioblastoma invasion. Biochem Biophys Res Commun 2008;369:1215-20
17. Zhang X, Bu XY, Zhen HN, et al. Expression and localisation of urokinase-type plasminogen activator gene in gliomas. J Clin Neurosci 2000;7:116-19
18. Hussaini IM, Karns LR, Vinton G, et al. Phorbol 12-myristate 13-acetate induces protein kinase acetate-specific proliferative response in astrocytic tumor cells. J Biol Chem 2000;275:22348-54
19. Amos S, Martin PM, Polar GA, et al. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. J Biol Chem 2005; 280:7729-38
20. Amos S, Mut M, diPierro CG, et al. Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and uroki-nase increases astrocytoma invasion. Cancer Res 2007;67:10241-51
21. Hussaini IM, Brown MD, Weaver AM, et al. Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptorY related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line. Antisense Nucleic Acid Drug Dev 1999;9: 183-90
22. Li H, Ye X, Mahanivong C, et al. Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. J Biol Chem 2005;280:10564-71
23. Zhao Y, Xiao A, Dipierro CG, et al. H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway. Glia 2008;56:917-24
24. Ishizawar RC, Miyake T, Parsons SJ. c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function. Oncogene 2007;26: 3503-10
25. Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell 2004;6:209-14
26. Konecny G, Untch M, Arboleda J, et al. Her-2/neu and urokinase-type plasminogen activator and its inhibitor in breast cancer. Clin Cancer Res 2001;7:2448-57
27. Libermann TA, Nusbaum HR, Razon N, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985;313:144-47
28. Watabe T, Yoshida K, Shindoh M, et al. The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and col-lagenase genes in response to epidermal growth factor. Int J Cancer 1998; 77:128-37
29. Ried S, Jäger C, Jeffers M, et al. Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor. J Biol Chem 1999;274:16377-86
30. Dunn SE, Torres JV, Oh JS, et al. Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase. Cancer Res 2001;61:1367-74
31. Hackel PO, Zwick E, Prenzel N, et al. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways. Curr Opin Cell Biol 1999;11:184-89
32. Zwick E, Hackel PO, Prenzel N, et al. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol Sci 1999;20: 408-1233
33. Friday BB, Adjei A. Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy. Clin Cancer Res 2008;14:342-46
34. RLrth P, Nerlov C, Blasi F, et al. Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in mu-rine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Nucleic Acids Res 1990;18:5009-17
35. Rao JS. Molecular mechanisms of glioma invasiveness: The role of proteases. Nat Rev Cancer 2003;3:489-501
36. Gondi CS, Lakka SS, Dinh DH, et al. Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth. Neuron Glia Biol 2004;1:165-76