Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis

Journal of Dermatological Science

Volumn 58, Issue 3, 2010, Pages 193-197

  Haas, Stefanie ^a   Capellino, Silvia ^a   Phan, Ngoc Quan ^b   Böhm, Markus ^b   Luger, Thomas A ^b   Straub, Rainer H ^a   Ständer, Sonja ^b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Atopic dermatitis; Hyperinnervation; Itch; Nerve fibers; NGF

Indexed keywords

NERVE GROWTH FACTOR; SUBSTANCE P; TYROSINE 3 MONOOXYGENASE;

ADULT; AGED; ARTICLE; CATECHOLAMINE SYNTHESIS; CELL DENSITY; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; LYMPHOCYTIC INFILTRATION; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; PRURIGO NODULARIS; SENSORY NERVE; SIGNAL TRANSDUCTION; SKIN DEFECT; SKIN DISEASE; SKIN PRURITUS; SYMPATHETIC NERVE; VISUAL ANALOG SCALE;

ADRENERGIC FIBERS; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CHRONIC DISEASE; DERMATITIS, ATOPIC; DERMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MIDDLE AGED; PRURIGO; PRURITUS; SENSORY RECEPTOR CELLS; SUBSTANCE P;

EID: 77953133224     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.03.020     Document Type: Article

References (33)

1. Ikoma A., Steinhoff M., Ständer S., Yosipovitch G., Schmelz M. The neurobiology of itch. Nat Rev Neurosci 2006, 7:535-547.
2. Paus R., Schmelz M., Biro T., Steinhoff M. Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest 2006, 116:1174-1186.
3. Ständer S., Weisshaar E., Luger T.A. Neurophysiological and neurochemical basis of modern pruritus treatment. Exp Dermatol 2008, 17:161-169.
4. Urashima R., Mihara M. Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study. Virchows Arch 1998, 432:363-370.
5. Tominaga M., Kamo A., Tengara S., Ogawa H., Takamori K. In vitro model for penetration of sensory nerve fibres on a Matrigel basement membrane: implications for possible application to intractable pruritus. Br J Dermatol 2009, 161:1028-1037.
6. Abadia M.F., Burrows N.P., Jones R.R., Terenghi G., Polak J.M. Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis. Br J Dermatol 1992, 127:344-351.
7. Tanaka M., Aiba S., Matsumura N., Aoyama H., Tagami H. Prurigo nodularis consists of two distinct forms: early-onset atopic and late-onset non-atopic. Dermatology 1995, 190:269-276.
8. Sugiura H., Omoto M., Hirota Y., Danno K., Uehara M. Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis. Arch Dermatol Res 1997, 289:125-131.
9. Ostlere L.S., Cowen T., Rustin M.H. Neuropeptides in the skin of patients with atopic dermatitis. Clin Exp Dermatol 1995, 20:462-467.
10. Thomsen J.S., Sonne M., Benfeldt E., Jensen S.B., Serup J., Menne T. Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch. Br J Dermatol 2002, 146:792-800.
11. Hägermark O., Hökfelt T., Pernow B. Flare and itch induced by substance P in human skin. J Invest Dermatol 1978, 71:233-235.
12. Lotz M., Vaughan J.H., Carson D.A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 1988, 241:1218-1221.
13. Lotz M., Carson D.A., Vaughan J.H. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 1987, 235:893-895.
14. Tanabe T., Otani H., Mishima K., Ogawa R., Inagaki C. Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells. Rheumatol Int 1996, 16:159-167.
15. Lieb K., Fiebich B.L., Berger M., Bauer J., Schulze-Osthoff K. The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 1997, 159:4952-4958.
16. Harrison N.K., Dawes K.E., Kwon O.J., Barnes P.J., Laurent G.J., Chung K.F. Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis. Am J Physiol 1995, 268:L278-L283.
17. Kahler C.M., Herold M., Wiedermann C.J. Substance P: a competence factor for human fibroblast proliferation that induces the release of growth-regulatory arachidonic acid metabolites. J Cell Physiol 1993, 156:579-587.
18. Kimball E.S., Fisher M.C. Potentiation of IL-1-induced BALB/3T3 fibroblast proliferation by neuropeptides. J Immunol 1988, 141:4203-4208.
19. Straub R.H., Cutolo M. Involvement of the hypothalamic - pituitary - adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum 2001, 44:493-507.
20. Konttinen Y.T., Kemppinen P., Segerberg M., Hukkanen M., Rees R., Santavirta S., Sorsa T., Pertovaara A., Polak J.M. Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain. Arthritis Rheum 1994, 37:965-982.
21. Ständer S., Weisshaar E., Mettang T., Szepietowski J.C., Carstens E., Ikoma A., Bergasa N.V., Gieler U., Misery L., Wallengren J., Darsow U., Streit M., Metze D., Luger T.A., Greaves M.W., Schmelz M., Yosipovitch G., Bernhard J.D. Clinical classification of itch: a position paper of the International Forum for the study of Itch. Acta Derm Venereol 2007, 87:291-294.
22. Lotts T., Klein D., Chatzigeorgakidis E., Iking A., Phan N.Q., Ständer S. Multidimensional database for pruritus patients - statistical evaluation of clinical characteristics. Acta Derm Venereol 2009, 89:691.
23. Weidler C., Holzer C., Harbuz M., Hofbauer R., Angele P., Scholmerich J., Straub R.H. Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 2005, 64:13-20.
24. Weigelt N, Metze D, Ständer S. Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients. J Cutan Pathol [Epub ahead of print].
25. Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. Eur J Dermatol 2002, 12:390-399.
26. Sivilia S., Paradisi M., D'Intino G., Fernandez M., Pirondi S., Lorenzini L., Calza L. Skin homeostasis during inflammation: a role for nerve growth factor. Histol Histopathol 2008, 23:1-10.
27. Verge V.M., Richardson P.M., Wiesenfeld-Hallin Z., et al. Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons. J Neurosci 1995, 15:2081-2096.
28. Lewin G.R., Mendell L.M. Nerve growth factor and nociception. Trends Neurosci 1993, 16:353-359.
29. Toyoda M., Nakamura M., Makino T., Hino T., Kagoura M., Morohashi M. Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol 2002, 147:71-79.
30. Linker R., Gold R., Luhder F. Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination. Crit Rev Immunol 2009, 29:43-68.
31. Miller L.E., Jüsten H.P., Schölmerich J., Straub R.H. The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 2000, 14:2097-2107.
32. Falabella R., Barona M.I., Echeverri I.C., Alzate A., Substance P may play a part during depigmentation in vitiligo. A pilot study. J Eur Acad Dermatol Venereol 2003, 17:355-356.
33. Ständer S., Siepmann D., Luger T.A. Targeting the neurokinin receptor 1 as a new antipruritic strategy: results of a case series with aprepitant. Acta Derm Venereol 2009, 89:717.