Oral acetyl-l-carnitine therapy and insulin resistance

Hypertension

Volumn 55, Issue 6, 2010, Pages

  Ruggenenti, Piero ^a,b   Van Der Meer, Irene M ^b,c   Remuzzi, Giuseppe ^a,b  

^a OSPEDALI RIUNITI   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LEVACECARNINE; PLACEBO;

CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG RESPONSE; HUMAN; HYPERTENSION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; NONHUMAN; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME;

ACETYLCARNITINE; ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERTENSION; INSULIN RESISTANCE; MALE; PILOT PROJECTS; RATS; SENSITIVITY AND SPECIFICITY;

EID: 77953124361     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.153767     Document Type: Letter

References (5)

1. Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi G. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Hypertension. 2009;54:567-574.
2. Muniyappa R. Oral carnitine therapy and insulin resistance. Hypertension. 2010;55:e13.
3. Ferrannini E, Buzzigoli G, Bevilacqua S, Boni C, Del Chiaro D, Oleggini M, Brandi L, Maccari F. Interaction of carnitine with insulin-stimulated glucose metabolism in humans. Am J Physiol. 1988;255:E946-E952.
4. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complicat. 1999;13:251-253.
5. Noland RC, Koves TR, Seiler SE, Lum H, Lust R, Ilkayeva O, Stevens R, Hegardt F, Muoio D. Carnitine insufficiency caused by aging and overnu-trition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009;284:22840-22852.