Haplotypes in the IL2RA region associated with diabetes and expression of the IL2RA protein on lymphocytes populations;Variants génétiques associés au diabète de type 1 et contrôle de l'expression du récepteur de l'IL-2

Medecine/Sciences

Volumn 26, Issue 3, 2010, Pages 236-238

  Plagnol, Vincent ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ARTICLE; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE; PHYSIOLOGY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTES; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 77953118914     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2010263236     Document Type: Article

References (5)

1. Wellcome Trust case control consortium. Genomewide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-78.
2. Dendrou C, Plagnol V, Fung E, et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009; 41: 1011-5.
3. Barrett JC, Clayton DG, Concannon P, et al. Genomewide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41: 703-7.
4. Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 39: 1074-82.
5. Bouatia-Naji N, Bonnefond A, Froguel P. Avancées dans la génétique de la glycémie à jeun: quelles leçons pour le diabète ?. Med Sci (Paris) 2009; 25: 897-902.