Structural basis for the non-immunosuppressive character of the cyclosporin A analogue debio 025

Biochemistry

Volumn 49, Issue 22, 2010, Pages 4679-4686

  Landrieu, Isabelle ^a   Hanoulle, Xavier ^a   Bonachera, Fanny ^a   Hamel, Arnaud ^b   Sibille, Nathalie ^a   Yin, Yanxia ^d   Wieruszeski, Jean Michel ^a   Horvath, Dragos ^c   Wei, Qun ^d   Vuagniaux, Grégoire ^b   Lippens, Guy ^a  

^a UNIV LILLE   (France)

^b DEBIOPHARM SA   (Switzerland)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CAN INTERFACE; CYCLOPHILIN A; CYCLOSPORIN A; HEPATITIS C; HYDROPHOBIC CAVITIES; IN-VITRO; METHYL GROUP; MOLECULAR LEVELS; NMR DATA; NMR SPECTROSCOPY; SHARP CONTRAST; SIDE CHAINS; STRUCTURAL BASIS; TERNARY COMPLEX; UNDECAPEPTIDE; VIRAL LIFE CYCLE;

HYDROCARBONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

HYDROPHOBICITY;

CALCINEURIN; CYCLOSPORIN A [3 N METHYL DEXTRO ALANINE 4 N ETHYLVALINE]; LEUCINE; VALINE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG STRUCTURE; HYDROPHOBICITY; IMMUNOSUPPRESSIVE TREATMENT; MOLECULAR INTERACTION; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CALCINEURIN; CYCLOSPORINE; DRUG INTERACTIONS; HEPACIVIRUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUCINE; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; VALINE; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 77953111743     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1003266     Document Type: Article

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