Protein/solvent medium effects on Mg2+-carboxylate interactions in metalloenzymes

Journal of the American Chemical Society

Volumn 132, Issue 18, 2010, Pages 6290-6291

  Babu, C Satheesan ^a   Lim, Carmay ^a,b  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; COFACTORS; EXPLICIT WATER; MEDIUM EFFECT; METALLOENZYMES; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN MEDIUM; RNASE H; STRUCTURE-BASED; THREE-DIMENSIONAL ARCHITECTURE; UMBRELLA SAMPLING;

CARBOXYLATION; ENERGY BARRIERS; ENZYMES; FREE ENERGY; MOLECULAR DYNAMICS;

BINDING ENERGY;

CARBOXYLIC ACID; MAGNESIUM ION; METAL COMPLEX; METALLOENZYME; SOLVENT; UNCLASSIFIED DRUG; ENZYME; MAGNESIUM; METALLOPROTEIN; RIBONUCLEASE H; WATER;

ARTICLE; BINDING SITE; CHEMICAL INTERACTION; ENZYME ANALYSIS; LIGAND BINDING; METAL BINDING; NONHUMAN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MURINE LEUKEMIA VIRUS; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

BINDING SITES; CARBOXYLIC ACIDS; DRUG DESIGN; ENZYMES; ESCHERICHIA COLI; HIV-1; LEUKEMIA VIRUS, MURINE; MAGNESIUM; METALLOPROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RIBONUCLEASE H; SOLVENTS; THERMODYNAMICS; WATER;

EID: 77953052006     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja101494m     Document Type: Article

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