Flow cytometric analysis of 4-HPR-induced apoptosis and cell cycle arrest in acute myelocytic leukemia cell line (NB-4)

Avicenna Journal of Medical Biotechnology

Volumn 2, Issue 1, 2010, Pages 53-61

  Fard, Shahrzad Soleymani ^a   Jeddi Tehrani, Mahmood ^b   Akhondi, Mohammad Mehdi ^b   Hashemi, Mehrdad ^c   Ardekani, Ali M ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

4 HPR; Acute myelocytic leukemia; Apoptosis; Cell differentiation; Flow cytometry

Indexed keywords

FENRETINIDE; PHOSPHATIDYLINOSITOL;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE;

EID: 77953043396     PISSN: 20082835     EISSN: 20084625     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. McKenzie SB. Advances in understanding the biology and genetics of acute myelocytic leukemia. Clin Lab Sci 2005;18(1):28-37.
2. Stone RM, O'Donnell MR, Sekeres MA. Acute myeloid leukemia. Hematology 2004;98-117.
3. Lovino CS, Camacho LH. A classification and treatment update. Clin J Oncol Nurs 2003;7(5):535-540.
4. Gale RP. Progress in acute myelogenous leukemia. Ann Intern Med l984;101:702-705.
5. Weinstein HJ, Mayer RJ, Rosenthal DS, Coral FS, Camitta BM, Gelber RD. Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update. Blood 1983;62(2):315-319. (Pubitemid 13036080)
6. Foon KA, Gale RP. Therapy of acute myelogenous leukemia. Blood Reviews 1992;6(1):15-25.
7. Deangelo DJ. The treatment of adolescents and young adults with acute lymphoblastic leukemia. Hematology 2005;123-130.
8. Darwiche N, Hatoum A, Dbaibo G, Kadara H, Nasr R, Abou-Lteif G, et al. N-(4-hydroxyphenyl) retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells. Leukemia 2004;18:607-615. (Pubitemid 38425877)
9. Sun SY, Yue P, Lotan R. Induction of apoptosis by N-(4-hydroxyphenyl) retinamide and its association with reactive oxygen species, nuclear retinoic acid receptors, and apoptosis related genes in human prostate carcinoma cells. Mol Pharmacol 1999;55(3):403-410. (Pubitemid 29128096)
10. Ulukaya E, Pirianov G, Kurt MA, Wood EJ, Mehmet H. Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation. Cell Death Differ 2003;10:856-859. (Pubitemid 36850248)
11. Yazdanparast R, Moosavi M, Mahdavi M, Lotfi A. Guanosine 5′-triphosphate induces differentiation dependent apoptosis in human leukemia U937 and KG1 cells. Acta Pharmacologica Sinica 2006;27(9):1175-1184. (Pubitemid 44410998)
12. Sun SY, Hail N Jr, Lotan R. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 2004;96(9):662-672. (Pubitemid 38660229)
13. Supino R, Crosti M, Clerici M, Warlters A, Cleris L, Zunino F, et al. Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression. Int J Cancer 1996;65(4):491-497. (Pubitemid 26084403)
14. Hail N Jr, Kim H J, Lotan R. Mechanisms of fenretinide- induced apoptosis. Apoptosis 2006 11:1677-1694.
15. Paulson JD, Oldham JW, Preston RF, Newman D. Lack of genotoxicity of the cancer chemopreventive agent N-(4-hydroxyphenyl) retinamide. Fundam Appl Toxicol 1985;5(1):144-150. (Pubitemid 15164324)
16. Lotan R. Retinoids and apoptosis: implications for chemoprevention and therapy. J Natl Cancer Inst 1995;87(22):1655-1657.
17. Faderl S, Lotan R, Kantarjian HM, Harris D, Van Q, Estrov Z. N-(4 Hydroxylphenyl) retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL). Leuk Res 2003;27(3):259-266.
18. Maurer BJ, Metelitsa LS, Seeger RC, Cabot MC, Reynolds CP. Increased of ceramide and induction of mixed apoptosis/ necrosis by N-(4-hydroxyphenyl) retinamide in neuroblastoma cell lines. J Natl Cancer Inst 1999;91(13):1138- 1146.
19. Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M, Tomita F. Staurosporine, a potent inhibitor of phospholipid/ Ca++dependent protein kinase. Biochem Biophys Res Commun 1986;135(2):397-402.
20. Kruman I, Guo Q, Mattson MP. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 1998;51(3):293-308.
21. DiPietrantonio AM, Hsieh T-C, Olson SC, Wu JM. Regulation of G1/ S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4-HPR). Int J Cancer 1998;78(1):53-61.
22. Greenberg ER, Sporn MB. Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med 1996;334(18):1189-1190.
23. Di Vinci A, Geido E, Infusini E, Giaretti W. Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl) retinamide. Int J Cancer 1994;59(3):422-426.
24. Kazmi SM, Plante RK, Visconti V, Lau CY. Comparison of N-(4-hydroxyphenyl) retinamide and all-trans-retinoic acid in the regulation of retinoid acid receptor-mediated gene expression in human breast cancer cell lines. Cancer Res 1996;56:1056-1062.
25. Scher RL, Saito W, Dodge RK, Richtsmeier WJ, Fine RL. Fenretinide-induced apoptosis of human head and neck squamous carcinoma cell lines. Otolaryngol Head Neck Surg 1998;118(4):464-471.
26. Coradini D, Biffi A, Pellizzaro C, Pirronello E, Di Fronzo G. Combined effect of tamoxifen or interferon-β and 4-hydroxyphenylretinamide on the growth of breast cancer cell lines. Tumour Biol 1997;18:22-29.
27. Delia D, Aiello A, Lombardi L, Pelicci PG, Grignani F, Grignani F, et al. N-(4 hydroxyphenyl) retinamide induces apoptosis of malignant hematopoietic cell lines including those unresponsive to retinoic acid. Cancer Res 1993;53(24):6036-6041. (Pubitemid 2015338)
28. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation and 13-cis-retinoic acid. Children's cancer group. N Engl J Med 1999;341(19):1165-1173.
29. Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley RW Jr, Webb TE. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995;15:805-810.
30. Ohshima M, Ward JM, Wenk ML. Preventive and enhancing effects of retinoids on the development of naturally occurring skin, prostate gland, and endocrine pancreas in aged male ACI/segHapBR rats. J Natl Cancer Inst 1985;74:517-524. (Pubitemid 15112141)
31. McCormick DL, Moon RC. Antipromotional activity of dietary N-(4 hydroxyphenyl) retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice. Cancer Lett 1986;31(2):133-138.
32. McCormick DL, Bagg BJ, Hultin TA. Comparative activity of dietary or topical exposure to three retinoids in the promotion of skin tumor induction in mice. Cancer Res 1987; 47:5989-5993.
33. Chodak GW, Rukstalis D, Kellman HM, Williams M. Phase II study of the retinoid analogue 4-HPR in men with carcinoma of the prostate. J Urol 1993;149:257.
34. Veronesi U, De Palo G, Marubini E, Costa A, Formelli F, Mariani L, et al. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst 1999;91(21):1847-1856. (Pubitemid 32166500)
35. Bernhard D, Tinhofer I, Tonko M, Hubi H, Ausserlechner MJ, Gril R, et al. Resveratrol causes arrest in the S-phase prior to Fas independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ 2000;7(9):834-842.
36. Rapaport E. Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle. J Cell Physiol 1983;114(3):279-283. (Pubitemid 13161547)
37. Gorin NC, Estey E, Jones RJ, Levitsky HI, Borrello I, Slavin S. New developments in the therapy of acute myelocytic leukemia. Hematology 2000;69-89.
38. Lodish H, Berk A, Zipursky SL, Baltimore D, Darneii JE. Molecular cell biology. 4th ed. New York: Scientific American; 2000.
39. Chan NP, Ma ESK, Wan TSK, Chan LC. The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype. Leuk Res 2003;27(3):231-234. (Pubitemid 36132112)
40. Chan LNL, Zhang S, Shao J, Waikela R, Thompson A, Chan TS. N-(4-Hydroxyphenyl) retinamide induces apoptosis in T lymphoma and T lymphoblastoid leukemia cells. Leuk Lymphoma 1997;25(3-4):271-280. (Pubitemid 27248178)