Administration of growth hormone in selectively protein-deprived rats decreases BMD and bone strength

Bone

Volumn 46, Issue 6, 2010, Pages 1574-1581

  Ammann, Patrick ^a   Brennan, Tara C ^a   Mekraldi, Samia ^a   Aubert, Michel L ^a   Rizzoli, René ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Bone strength; Bone turnover; Growth hormone; Protein undernutrition

Indexed keywords

CASEIN; DEOXYPYRIDINOLINE; GROWTH HORMONE; OSTEOCALCIN; SOMATOMEDIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE METABOLISM; BONE STRENGTH; BONE TURNOVER; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; MORPHOMETRICS; MUSCLE MASS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN INTAKE; RAT;

ANIMALS; BIOMECHANICS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; CASEINS; CATTLE; DIET, PROTEIN-RESTRICTED; FEMALE; GROWTH HORMONE; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77953028406     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.02.015     Document Type: Article

References (40)

1. Conigrave A.D., Brown E.M., Rizzoli R. Dietary protein and bone health: roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis. Ann Rev Nutrition 2008, 28:131-155.
2. Rizzoli R., Bonjour J.P. Dietary protein and bone health. J Bone Miner Res 2004, 19:527-531.
3. Bastow M.D., Rawlings J., Allison S.P. Undernutrition, hypothermia, and injury in elderly women with fractured femur: an injury response to altered metabolism?. Lancet 1983, 1:143-146.
4. Geinoz G., Rapin C.H., Rizzoli R., Kraemer R., Buchs B., Slosman D., et al. Relationship between bone mineral density and dietary intakes in the elderly. Ost Intl 1993, 3:242-248.
5. Rizzoli R. Nutrition: its role in bone health. Best Practice Res Clin Endo Met 2008, 22:813-829.
6. Rizzoli R., Ammann P., Chevalley T., Bonjour J.P. Protein intake and bone disorders in the elderly. Joint Bone Spine 2001, 68:383-392.
7. Schurch M., Rizzoli R., Slosman D., Vadas L., Vergnaud P., Bonjour J.P. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998, 801-809.
8. Bourrin S., Ammann P., Bonjour J.P., Rizzoli R. Dietary protein restriction lowers plasma insulin-like growth factor I (IGF-I), impairs cortical bone formation, and induces osteoblastic resistance to IGF-I in adult female rats. Endocrinology 2000, 141:3149-3155.
9. Ammann P., Laib A., Bonjour J.P., Meyer J.M., Ruegsegger P., Rizzoli R. Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet. J Bone Miner Res 2002, 17:1264-1272.
10. Bourrin S., Toromanoff A., Bonjour J.P., Rizzoli R. Dietary protein deficiency induces osteoporosis in aged male rats. J Bone Miner Res 2000, 15:1555-1563.
11. Canalis E., Agnusdei D. Insulin-like growth factors and their role in osteoporosis. Calcif Tissue Int 1996, 58:133-134.
12. Isley W.L., Underwood L.E., Clemmons D.R. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest 1983, 71:175-182.
13. Rosen C.J. Growth hormone, insulin-like growth factors, and the senescent skeleton: Ponce de Leon's Fountain revisited?. J Cell Biochem 1994, 56:527-531.
14. Straus D.S., Takemoto C.D. Effect of dietary protein deprivation on insulin-like growth factor (IGF)-I and -II, binding protein-2, and serum albumin gene expression in rat. Endocrinology 1990, 127.
15. Thissen J.P., Pucilowska J.B., Underwood L.E. Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture. Endocrinology 1994, 134:1570-1576.
16. VandeHaar M.J., Moats-Staats B.M., Davenport M.L., Walker J.L., Ketelslegers J.M., Sharma B.K., et al. Reduced serum concentrations of insulin-like growth factor-I (IGF-I) in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle. J Endocrinol 1991, 130:305-312.
17. Gamero P., Sornay-Rendu E., Delmas P.D. Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet 2000, 355:898-899.
18. Garnero P., Tsouderos Y., Marton I., Pelissier C., Varin C., Delmas P.D. Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like growth factor I in postmenopausal women. J Clin Endocrinol Metab 1999, 84:2390-2397.
19. Rosen C.J., Wuster C. Growth hormone rising: did we quit too quickly?. J Bone Miner Res 2003, 18:406-409.
20. Joseph F., Ahmad A.M., Ul-Haq M., Durham B.H., Whittingham P., Fraser W.D., et al. Effects of growth hormone administration on bone mineral metabolism, PTH sensitivity and PTH secretory rhythm in postmenopausal women with established osteoporosis. J Bone Miner Res 2008, 23:721-729.
21. Thissen J.P., Ketelslegers J.M., Underwood L.E. Nutritional regulation of the insulin-like growth factors. Endocr Rev 1994, 15:80-101.
22. Tseng K.-F., Goldstein S. Systemic over-secretion of growth hormone in transgenic mice results in a specific pattern of skeletal modeling and adaptation. J Bone Miner Res 1998, 13:706-715.
23. Tseng K.-F., Bonadio J.F., Stewart S.A., Baker A.R., Goldstein S.A. Local expression of human growth hormone in bone results in impaired mechanical integrity in the skeletal tissue of transgenic mice. J Orthop Res 1996, 14:598-604.
24. Ammann P., Rizzoli R., Slosman D., Bonjour J.P. Sequential and precise in vivo measurement of bone mineral density in rats using dual-energy x-ray absorptiometry. J Bone Miner Res 1992, 7:311-316.
25. Ammann P., Rizzoli R., Meyer J.M., Bonjour J.P. Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized rats. Osteoporos Int 1996, 6:219-227.
26. Ammann P., Bourrin S., Bonjour J.P.., Meye J.M.., Rizzoli R. Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency. J Bone Miner Res 2000, 15:683-690.
27. Chappard D., Palle S., Alexandre C., Vico L., Riffat G. Bone embedding in pure methyl methacrylate at low temperature preserves enzyme activities. Acta Histochem 1987, 81:183-190.
28. Chappard D., Alexandre C., Camps M., Montheard J.P., Riffat G. Embedding iliac bone biopsies at low temperature using glycol and methyl methacrylates. Stain Technol 1983, 58:299-308.
29. Bourrin S., Palle S., Genty C., Alexandre C. Physical exercise during remobilization restores a normal bone trabecular network after tail suspension-induced osteopenia in young rats. J Bone Miner Res 1995, 10:820-828.
30. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
31. Kotzmann H., Yilmaz N., Lercher P., Riedl M., Schmidt A., Schuster E., et al. Differential effects of growth hormone therapy in malnourished hemodialysis patients. Kidney Int 2001, 60:1578-1585.
32. Kotzmann H., Riedl M., Pietschmann P., Schmidt A., Schuster E., Kreuzer S., et al. Effects of 12months of recombinant growth hormone therapy on parameters of bone metabolism and bone mineral density in patients on chronic hemodialysis. J Nephrology 2004, 17:87-94.
33. Rosen H.N., Chen V., Cittadini A., Greenspan S.L., Douglas P.S., Moses A.C., et al. Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density. J Bone Miner Res 1995, 10:1352-1358.
34. Wang Y., Nishida S., Elalieh H.Z., Long R.K., Halloran B.P., Bikle D.D. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res 2006, 21:1350-1358.
35. Papadakis M.A., Grady D., Black D., Tierney M.J., Gooding G.A.W., Schambelan M., et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996, 124:708-716.
36. Rudman D., Feller A.G., Nagraj H.S., Gergans G.A., Lalitha P.Y., et al. Effects of human growth hormone in men over 60years old. N EJM 1990, 323:1-6.
37. Landin-Wilhelmsen K., Nilsson A., Bosaeus I., Bengtsson B.-Ã.K. Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial. J Bone Miner Res 2003, 18:393-405.
38. Koutkia P., Canavan B., Breu J., Grinspoon S. Effects of growth hormone-releasing hormone on bone turnover in human immunodeficiency virus-infected men with fat accumulation. J Clin Endocrinol Metab 2005, 90:2154-2160.
39. Misra M., Klibanski A. Anorexia nervosa and osteoporosis. Rev Endoc Met Disord 2006, 7:91-99.
40. Fritton J.C., Emerton K.B., Sun H., Kawashima Y., Mejia W., Wu Y., et al. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating IGF-1. J Bone Miner Res EPub-ahead of print 2009, 1-36.