The pathophysiology of hypoactive sexual desire disorder in women

International Journal of Gynecology and Obstetrics

Volumn 110, Issue 1, 2010, Pages 7-11

  Clayton, Anita H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Female sexual dysfunction; HSDD; Hypoactive Sexual Desire Disorder; Pathophysiology; Risk factors

Indexed keywords

ANTIHYPERTENSIVE AGENT; DOPAMINE; NEUROLEPTIC AGENT; OPIATE; ORAL CONTRACEPTIVE AGENT; PROGESTERONE; PROLACTIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TESTOSTERONE;

AGING; CLIMACTERIUM; COMORBIDITY; DEPRESSION; DOPAMINE RELEASE; EMOTION; FEMALE SEXUAL DYSFUNCTION; HORMONAL REGULATION; HUMAN; HYPOACTIVE SEXUAL DESIRE DISORDER; INTIMACY; LIMBIC SYSTEM; MENOPAUSE; NEUROBIOLOGY; NEUROTRANSMISSION; NONHUMAN; ORGASM DISORDER; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEDATION; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SOCIAL PSYCHOLOGY; VENTRAL TEGMENTUM; ADULT; ANIMAL; BRAIN; EUROPE; FEMALE; LIBIDO; METABOLISM; RISK FACTOR; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; UNITED STATES;

ADULT; ANIMALS; BRAIN; EUROPE; FEMALE; HUMANS; LIBIDO; RISK FACTORS; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; UNITED STATES;

EID: 77953024788     PISSN: 00207292     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijgo.2010.02.014     Document Type: Review

References (46)

1. Shifren J.L., Monz B.U., Russo P.A., Segreti A., and Johannes C.B. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol 112 5 (2008) 970-978
2. Leiblum S.R., Koochaki P.E., Rodenberg C.A., Barton I.P., and Rosen R.C. Hypoactive Sexual Desire Disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 13 1 (2006) 46-56
3. Dennerstein L., Koochaki P., Barton I., and Graziottin A. Hypoactive Sexual Desire Disorder in menopausal women: a survey of Western European women. J Sex Med 3 2 (2006) 212-222
4. Hayes R.D., Dennerstein L., Bennett C.M., and Fairley C.K. What is the "true" prevalence of female sexual dysfunctions and does the way we assess these conditions have an impact?. J Sex Med 5 4 (2008) 777-787
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th edition, text revision (2000), American Psychiatric Press, Washington, DC
6. Marwick C. Survey says patients expect little physician help on sex. JAMA 281 23 (1999) 2173-2174
7. Harsh V., McGarvey E.L., and Clayton A.H. Physician attitudes regarding Hypoactive Sexual Desire Disorder in a primary care clinic: a pilot study. J Sex Med 5 3 (2008) 640-645
8. Masters W.H., and Johnson V.E. Human Sexual Response (1966), Little, Brown, Boston
9. Kaplan H.S. Disorders of sexual desire and other new concepts and techniques in sex therapy (1979), Brunner/Hazel Publications, New York
10. Basson R. Female sexual response: the role of drugs in the management of sexual dysfunction. Obstet Gynecol 98 2 (2001) 350-353
11. Sand M., and Fisher W.A. Women's endorsement of models of female sexual response: the nurses' sexuality study. J Sex Med 4 3 (2007) 708-719
12. Giles K.R., and McCabe M.P. Conceptualizing women's sexual function: linear vs. circular models of sexual response. J Sex Med 6 10 (2009) 2761-2771
13. Hull E.M., Lorrain D.S., Du J., Matuszewich L., Lumley L.A., Putnam S.K., et al. Hormone-neurotransmitter interactions in the control of sexual behavior. Behav Brain Res 105 1 (1999) 105-116
14. Becker J.B. Direct effect of 17 beta-estradiol on striatum: sex differences in dopamine release. Synapse 5 2 (1990) 157-164
15. Sato S., Braham C.S., Putnam S.K., and Hull E.M. Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity. Brain Res 1043 1-2 (2005) 205-213
16. Halaris A. Neurochemical aspects of the sexual response cycle. CNS Spectr 8 3 (2003) 211-216
17. Pfaus J.G., and Gorzalka B.B. Opioids and sexual behavior. Neurosci Biobehav Rev 11 1 (1987) 1-34
18. Clayton A.H. Sexual function and dysfunction in women. Psychiatr Clin North Am 26 3 (2003) 673-682
19. Persky H., Lief H.I., Strauss D., Miller W.R., and O'Brien C.P. Plasma testosterone level and sexual behavior of couples. Arch Sex Behav 7 3 (1978) 157-173
20. Bachmann G., Bancroft J., Braunstein G., Burger H., Davis S., Dennerstein L., et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 77 4 (2002) 660-665
21. Janssen E., and Bancroft J. The dual control model. The role of sexual inhibition and excitation in sexual arousal and behavior. In: Janssen E. (Ed). The psychophysiology of sex (2007), Indiana University Press, Bloomington 197-222
22. Laumann E.O., Paik A., and Rosen R.C. Sexual dysfunction in the United States: prevalence and predictors. JAMA 281 6 (1999) 537-544
23. Burleson M.H., Trevathan W.R., and Todd M. In the mood for love or vice versa? Exploring the relations among sexual activity, physical affection, affect, and stress in the daily lives of mid-aged women. Arch Sex Behav 36 3 (2007) 357-368
24. Bancroft J., Loftus J., and Long J.S. Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav 32 3 (2003) 193-208
25. Laumann E.O., Nicolosi A., Glasser D.B., Paik A., Gingell C., Moreira E., et al. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 17 1 (2005) 39-57
26. Dennerstein L., and Lehert P. Modeling mid-aged women's sexual functioning: a prospective, population-based study. J Sex Marital Ther 30 3 (2004) 173-183
27. Johnson S.D., Phelps D.L., and Cottler L.B. The association of sexual dysfunction and substance use among a community epidemiological sample. Arch Sex Behav 33 1 (2004) 55-63
28. Hayes R.D., Dennerstein L., Bennett C.M., Koochaki P.E., Leiblum S.R., and Graziottin A. Relationship between Hypoactive Sexual Desire Disorder and aging. Fertil Steril 87 1 (2007) 107-112
29. Judd H.L., Judd G.E., Lucas W.E., and Yen S.S. Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 39 6 (1974) 1020-1024
30. Hawighorst-Knapstein S., Fusshoeller C., Franz C., Trautmann K., Schmidt M., Pilch H., et al. The impact of treatment for genital cancer on quality of life and body image-results of a prospective longitudinal 10-year study. Gynecol Oncol 94 2 (2004) 398-403
31. Basson R. Recent advances in women's sexual function and dysfunction. Menopause 11 6 Pt 2 (2004) 714-725
32. Kingsberg S.A. The impact of aging on sexual function in women and their partners. Arch Sex Behav 31 5 (2002) 431-437
33. Basson R., and Schultz W.W. Sexual sequelae of general medical disorders. Lancet 369 9559 (2007) 409-424
34. Salonia A., Zanni G., Nappi R.E., Briganti A., Deho F., Fabbri F., et al. Sexual dysfunction is common in women with lower urinary tract symptoms and urinary incontinence: Results of a cross-sectional study. Eur Urol 45 5 (2004) 642-648
35. Alder J., Zanetti R., Wight E., Urech C., Fink N., and Bitzer J. Sexual dysfunction after premenopausal stage I and II breast cancer: do androgens play a role?. J Sex Med 5 8 (2008) 1898-1906
36. Bossini L., Fagiolini A., Valdagno M., Polizzotto N.R., and Castrogiovanni P. Sexual disorders in subjects treated for mood and anxiety diseases. J Clin Psychopharmacol 27 3 (2007) 310-312
37. Clayton A.H. Epidemiology and neurobiology of female sexual dysfunction. J Sex Med 4 Suppl 4 (2007) 260-268
38. Clayton A.H., Pradko J.F., Croft H.A., Montano C.B., Leadbetter R.A., Bolden-Watson C., et al. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 63 4 (2002) 357-366
39. Smith P.J., and Talbert R.L. Sexual dysfunction with antihypertensive and antipsychotic agents. Clin Pharm 5 5 (1986) 373-384
40. Palha A.P., and Esteves M. Drugs of abuse and sexual functioning. Adv Psychosom Med 29 (2008) 131-149
41. Schaffir J. Hormonal contraception and sexual desire: a critical review. J Sex Marital Ther 32 4 (2006) 305-314
42. Panzer C., Wise S., Fantini G., Kang D., Munarriz R., Guay A., et al. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunction. J Sex Med 3 1 (2006) 104-113
43. Rellini A., and Meston C. Sexual function and satisfaction in adults based on the definition of child sexual abuse. J Sex Med 4 5 (2007) 1312-1321
44. Bachmann G. Female sexuality and sexual dysfunction: are we stuck on the learning curve?. J Sex Med 3 4 (2006) 639-645
45. Clayton A.H., Goldfischer E.R., Goldstein I., Derogatis L., Lewis-D'Agostino D.J., and Pyke R. Validation of the Decreased Sexual Desire Screener (DSDS): A Brief Diagnostic Instrument for Generalized Acquired Female Hypoactive Sexual Desire Disorder (HSDD). J Sex Med 6 (2009) 730-738
46. Simon J.A. Opportunities for intervention in HSDD. J Fam Pract 58 7 Suppl Hypoactive (2009) S26-S30