Purified PTP1 protein induces antigen-specific protective immunity against Encephalitozoon cuniculi

Microbes and Infection

Volumn 12, Issue 7, 2010, Pages 574-579

  Moretto, Magali M ^a   Lawlor, Elizabeth M ^a   Xu, Yanji ^b   Khan, Imtiaz A ^a   Weiss, Louis M ^b  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Immunization; Microsporidia; T cells

Indexed keywords

FUNGAL PROTEIN; POLAR TUBE PROTEIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; ENCEPHALITOZOON; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOON HELLEM; ENCEPHALITOZOONOSIS; ENZYME PURIFICATION; FEMALE; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD8; CARRIER PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOONOSIS; FEMALE; FUNGAL PROTEINS; FUNGAL VACCINES; IMMUNITY, CELLULAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

ANIMALIA; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOON HELLEM; MICROSPORIDIA; MICROSPORIDIUM; MUS;

EID: 77953022836     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2010.03.008     Document Type: Article

References (23)

1. In: Wittner M., and Weiss L.M. (Eds). The Microsporidia and Microsporidiosis (1999), American Society of Microbiology, Washington, DC
2. Fournier S., Liguory O., Sarfati C., David-Ouaknine F., Derouin F., Decazes J.M., and Molina J.M. Disseminated infection due to Encephalitozoon cuniculi in a patient with AIDS: case report and review. HIV Med. 1 (2000) 155-161
3. Weitzel T., Wolff M., Dabanch J., Levy I., Schmetz C., Visvesvara G.S., and Sobottka I. Dual microsporidial infection with Encephalitozoon cuniculi and Enterocytozoon bieneusi in an HIV-positive patient. Infection 29 (2001) 237-239
4. Botterel F., Minozzi C., Vittecoq D., and Bouree P. Pulmonary localization of Enterocytozoon bieneusi in an AIDS patient: case report and review. J. Clin. Microbiol. 40 (2002) 4800-4801
5. Scaglia M., Sacchi L., Croppo G.P., da Silva A., Gatti S., Corona S., Orani A., Bernuzzi A.M., Pieniazek N.J., Slemenda S.B., Wallace S., and Visvesvara G.S. Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS. J. Infect. 34 (1997) 119-126
6. Svedhem V., Lebbad M., Hedkvist B., Del Aguila C., Hedman P., Larsson R., Navajas R., and Aust-Kettis A. Disseminated infection with Encephalitozoon intestinalis in AIDS patients: report of 2 cases. Scand. J. Infect. Dis. 34 (2002) 703-705
7. Schmidt E.C., and Shadduck J.A. Murine encephalitozoonosis model for studying the host-parasite relationship of a chronic infection. Infect. Immun. 40 (1983) 936-942
8. Schmidt E.C., and Shadduck J.A. Mechanisms of resistance to the intracellular protozoan Encephalitozoon cuniculi in mice. J. Immunol. 133 (1984) 2712-2719
9. Moretto M., Casciotti L., Durell B., and Khan I.A. Lack of CD4(+) T cells does not affect induction of CD8(+) T-cell immunity against Encephalitozoon cuniculi infection. Infect. Immun. 68 (2000) 6223-6232
10. Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., and Weiss L.M. The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans. Mol. Biochem. Parasitol. 94 (1998) 227-236
11. Keohane E.M., Orr G.A., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., and Weiss L.M. Purification and characterization of human microsporidian polar tube proteins. J. Eukaryot. Microbiol. 43 (1996) 100S
12. Keohane E.M., Orr G.A., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., and Weiss L.M. Purification and characterization of a microsporidian polar tube protein. Mol. Biochem. Parasitol. 79 (1996) 255-259
13. + T cell immune response against Encephalitozoon cuniculi infection. J. Immunol. 166 (2001) 7389-7397
14. Moretto M.M., Lawlor E.M., and Khan I.A. Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen. J. Immunol. 181 (2008) 7977-7984
15. Moretto M.M., Weiss L.M., Combe C.L., and Khan I.A. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J. Immunol. 179 (2007) 2485-2492
16. + CTLs are essential for protective immunity against Encephalitozoon cuniculi infection. J. Immunol. 162 (1999) 6086-6091
17. Keohane E.M., Orr G.A., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., and Weiss L.M. Polar tube proteins of microsporidia of the family encephalitozoonidae. J. Eukaryot. Microbiol. 46 (1999) 1-5
18. Moretto M., Weiss L.M., and Khan I.A. Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infection. J. Immunol. 172 (2004) 4402-4409
19. + T cells. J. Immunol. 162 (1999) 2890-2894
20. Khan I.A., Matsuura T., and Kasper L.H. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect. Immun. 62 (1994) 1639-1642
21. Leav B.A., Yoshida M., Rogers K., Cohen S., Godiwala N., Blumberg R.S., and Ward H. An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice. Infect. Immun. 73 (2005) 8425-8428
22. Wang X., Kang H., Kikuchi T., and Suzuki Y. Gamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease. Infect. Immun. 72 (2004) 4432-4438
23. E. Enriquez, Microsporidia: immunity and immunodiagnosis, in: Second Workshop on Microsporidiosis and Cryptosporidiosis Immunodeficient Patients, Ceske Budejovice, Cezh Republic, 1997, p. 16.