Application of a Bayesian deconvolution approach for high-resolution 1H NMR spectra to assessing the metabolic effects of acute phenobarbital exposure in liver tissue

Analytical Chemistry

Volumn 82, Issue 11, 2010, Pages 4479-4485

  Rubtsov, Denis V ^a   Waterman, Claire ^a   Currie, Richard A ^b   Waterfield, Catherine ^b   Salazar, José Domingo ^b   Wright, Jayne ^b   Griffin, Julian L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BAYESIAN; BAYESIAN MODELING; BIO-MARKER DISCOVERY; BIOFLUIDS; BIOLOGICAL PROCESS; DECONVOLUTION APPROACH; FALSE DISCOVERY RATE; FREE INDUCTION DECAY; H NMR SPECTRA; H NMR SPECTROSCOPY; HIGH RESOLUTION; INFORMATION EXTRACTION; LIVER TISSUE; METABOLIC EFFECTS; METABOLIC PROFILES; METABOLOMICS; NMR SPECTRUM; NON-PARAMETRIC; NUMBER OF COMPONENTS; TIME DOMAIN; TISSUE EXTRACTS;

CONVOLUTION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNAL PROCESSING;

BAYESIAN NETWORKS;

BIOLOGICAL MARKER; GLYCINE; PHENOBARBITAL;

ANIMAL; ARTICLE; BAYES THEOREM; CYTOLOGY; DRUG EFFECT; LABORATORY DIAGNOSIS; LIVER; MALE; METABOLISM; METABOLOMICS; METHODOLOGY; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; STATISTICS;

ANIMALS; BAYES THEOREM; BIOLOGICAL MARKERS; FALSE POSITIVE REACTIONS; GLYCINE; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MULTIVARIATE ANALYSIS; PHENOBARBITAL; RATS;

EID: 77953000217     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac100344m     Document Type: Article

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