Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States

AIDS Patient Care and STDs

Volumn 24, Issue 5, 2010, Pages 279-286

  Melekhin, Vlada V ^a   Shepherd, Bryan E ^b   Jenkins, Cathy A ^b   Stinnette, Samuel E ^a,c   Rebeiro, Peter F ^a   Bebawy, Sally S ^a   Rasbach, Daniel A ^a   Hulgan, Todd ^a   Sterling, Timothy R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c Comprehensive Care Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AFRICAN AMERICAN; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; DEATH; DRUG ABUSE; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MAJOR CLINICAL STUDY; MATERNAL MORTALITY; PREGNANCY; PROGNOSIS; PUERPERIUM; RETROSPECTIVE STUDY; UNITED STATES;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROPORTIONAL HAZARDS MODELS; RNA, VIRAL; SURVIVAL RATE; TENNESSEE; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 77952977181     PISSN: 10872914     EISSN: None     Source Type: Journal    
DOI: 10.1089/apc.2009.0283     Document Type: Article

References (23)

1. Palella FJ, Jr., Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-860.
2. Achievements in public health. Reduction in perinatal transmission of HIV infection-United States, 1985-2005. MMWR Morb Mortal Wkly Rep 2006;55:592-597.
3. Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 2003;9:727-728.
4. Morse CG, Kovacs JA. Metabolic and skeletal complications of HIV infection: The price of success. JAMA 2006;296:844-854.
5. Harrington M, Carpenter CC. Hit HIV-1 hard, but only when necessary. Lancet 2000;355:2147-2152.
6. Johnson VA, Brun-Vezinet F, Clotet B, et al. Update of the Drug Resistance Mutations in HIV-1. Top HIV Med 2008;16: 138-145.
7. Cardiello PG, Hassink E, Ananworanich J, et al. A prospective, randomized trial of structured treatment interruption for patients with chronic HIV type 1 infection. Clin Infect Dis 2005;40:594-600.
8. Krolewiecki AJ, Zala C, Vanzulli C, et al. Safe treatment interruptions in patients with nadir CD4 counts of more than 350 cells=mL: A randomized trial. J Acquir Immune Defic Syndr 2006;41:425-429.
9. El-Sadr WM, Lundgren JD, Neaton JD, et al. CD4+ countguided interruption of antiretroviral treatment. N Engl J Med 2006;355:2283-2296.
10. Perinatal HIV Guidelines Working Group. Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States. July 8, 2008:1-98. http:== aidsinfo.nih.gov=ContentFiles= PerinatalGL.pdf (Last accessed September 30, 2009).
11. National Institute of Allergy and Infectious Diseases. HAART Standard Version of the Promoting Maternal and Infant Survival Everywhere (PROMISE) Study. National Library of Medicine (US). November 25, 2009. http:== clinicaltrials.gov=ct2=show=NCT00955968?term=promise& rank=12 ((Last accessed September 30, 2009).
12. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance care definition for AIDS among adolescents and adults. MMWR Recomm Rep 1992;41:1-19.
13. Fusco GP, Jusitce AC, Becker SL, Raffanti SP, Coll-Erickson P, Fusco JS. Strategies for obtaining consistent diagnoses for cause of death in an HIV observational cohort study. Poster Exhibit: The XIV International AIDS Conference 2002: Abstract no. TuPeG5686.
14. Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999;94: 496-509.
15. Danel C, Moh R, Minga A, et al. CD4-guided structured antiretroviral treatment interruption strategy in HIVinfected adults in west Africa (Trivacan ANRS 1269 trial): a randomized trial. Lancet 2006;367:1981-1989.
16. Onen NF, Nurutdinova D, Sungkanuparph S, Gase D, Mondy K, Overton ET. Effect of postpartum HIV treatment discontinuation on long-term maternal outcome. J Int Assoc Physicians AIDS Care (Chic Ill) 2008;7:245-251.
17. Martin F, Navaratne L, Khan W, et al. Pregnant women with HIV infection can expect healthy survival: Threeyear follow-up. J Acquir Immune Defic Syndr 2006;43: 186-192.
18. Watts DH, Lu M, Thompson B, et al. Treatment interruption after pregnancy: Effects on disease progression and laboratory findings. Infect Dis Obstet Gynecol 2009;2009:456717.
19. Baroncelli S, Tamburrini E, Ravizza M, et al. Antiretroviral treatment in pregnancy:Asix-year perspective on recent trends in prescription patterns, viral load suppression, and pregnancy outcomes. AIDS Patient Care STDs 2009;23:513-520.
20. Pogany K, van Valkengoed IG, Prins JM, et al. Effects of active treatment discontinuation in patients with a CD4+ T-cell nadir greater than 350 cells=mm3: 48-week Treatment Interruption in Early Starters Netherlands Study (TRIESTAN). J Acquir Immune Defic Syndr 2007;44:395-400.
21. Steingrover R, Pogany K, Fernandez Garcia E, et al. HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy. AIDS 2008;22:1583-1588.
22. Miller LG, Hays RD. Measuring adherence to antiretroviral medications in clinical trials. HIV Clin Trials 2000;1:36-46.
23. United Nations Joint Programme on HIV=AIDS. 2007 AIDS epidemic update. 2008. www.unaids.org=en= (Last accessed September 30, 2009).