Rivastigmine in the treatment of dementia associated with Parkinson's disease: Effects on activities of daily living

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 6, 2010, Pages 510-515

  Olin, Jason T ^a   Aarsland, Dag ^b   Meng, Xiangyi ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b STAVANGER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Activities of daily living; Parkinson's disease; Rivastigmine

Indexed keywords

PLACEBO; RIVASTIGMINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEMENTIA; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARKINSON DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; CHOLINESTERASE INHIBITORS; DEMENTIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PHENYLCARBAMATES; TREATMENT OUTCOME;

EID: 77952967621     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000305100     Document Type: Article

References (32)

1. Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sorensen P: Risk of dementia in Parkinson's disease: a communitybased, prospective study. Neurology 2001; 56: 730-736.
2. Hobson P, Meara J: Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom. Mov Disord 2004; 19: 1043-1049.
3. Buter TC, van den Hout A, Matthews FE, Larsen JP, Brayne C, Aarsland D: Dementia and survival in Parkinson disease: a 12-year population study. Neurology 2008; 70: 1017-1022.
4. Aarsland D, Andersen K, Larsen JP, Lolk A, Kragh-Sorensen P: Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol 2003; 60: 387-392.
5. Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG: The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord 2008; 23: 837-844.
6. Huber SJ, Paulson GW, Shuttleworth EC: Relationship of motor symptoms, intellectual impairment, and depression in Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 855-858.
7. Bronnick K, Ehrt U, Emre M, De Deyn PP, Wesnes K, Tekin S, Aarsland D: Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease. J Neurol Neurosurg Psychiatry 2006; 77: 1136-1142.
8. Allan L, McKeith I, Ballard C, Kenny RA: The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life. Dement Geriatr Cogn Disord 2006; 22: 230-237.
9. Schrag A, Jahanshahi M, Quinn N: What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry 2000; 69: 308-312.
10. McKinlay A, Grace RC, Dalrymple-Alford JC, Anderson T, Fink J, Roger D: A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson's disease patients without dementia. Parkinsonism Relat Disord 2008; 14: 37-42.
11. Aarsland D, Bronnick K, Ehrt U, De Deyn PP, Tekin S, Emre M, Cummings JL: Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 2007; 78: 36-42.
12. Aarsland D, Larsen JP, Karlsen K, Lim NG, Tandberg E: Mental symptoms in Parkinson's disease are important contributors to caregiver distress. Int J Geriatr Psychiatry 1999; 14: 866-874.
13. Stella F, Banzato CE, Quagliato EM, Viana MA, Christofoletti G: Psychopathological features in patients with Parkinson's disease and related caregivers' burden. Int J Geriatr Psychiatry 2009.
14. Andersen CK, Wittrup-Jensen KU, Lolk A, Andersen K, Kragh-Sorensen P: Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia. Health Qual Life Outcomes 2004; 2: 52.
15. Marras C, Lang A: Invited article: Changing concepts in Parkinson disease: Moving beyond the decade of the brain. Neurology 2008; 70: 1996-2003.
16. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K: Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004; 318: 121-134.
17. Farlow MR, Miller ML, Pejovic V: Treatment options in Alzheimer's disease: maximizing benefit, managing expectations. Dement Geriatr Cogn Disord 2008; 25: 408-422.
18. Emre M: Treatment of dementia associated with Parkinson's disease. Parkinsonism Relat Disord 2007; 13(suppl 3):S457-S461.
19. Bohnen NI, Kaufer DI, Ivanco LS, Lopresti B, Koeppe RA, Davis JG, Mathis CA, Moore RY, DeKosky ST: Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Arch Neurol 2003; 60: 1745-1748.
20. Bohnen NI, Kaufer DI, Hendrickson R, Ivanco LS, Lopresti BJ, Constantine GM, Mathis Ch A, Davis JG, Moore RY, Dekosky ST: Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia. J Neurol 2006; 253: 242-247.
21. Perry EK, Curtis M, Dick DJ, Candy JM, Atack JR, Bloxham CA, Blessed G, Fairbairn A, Tomlinson BE, Perry RH: Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985; 48: 413-421.
22. Hilker R, Thomas AV, Klein JC, Weisenbach S, Kalbe E, Burghaus L, Jacobs AH, Herholz K, Heiss WD: Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology 2005; 65: 1716-1722.
23. Novartis Pharmaceuticals Corporation. Exelon Capsule: Prescribing information.
24. Novartis Pharmaceuticals Corporation. Exelon Transdermal Patch: Prescribing information.
25. Emre M, Aarsland D, Albanese A, Byrne EJ, Deuschl G, De Deyn PP, Durif F, Kulisevsky J, van Laar T, Lees A, Poewe W, Robillard A, Rosa MM, Wolters E, Quarg P, Tekin S, Lane R: Rivastigmine for dementia associated with Parkinson's disease. N Engl J Med 2004; 351: 2509-2518. (Pubitemid 39603164)
26. Gibb WR, Lees AJ: The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 745-752.
27. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4, text revision (DSM-IV-TR ). Arlington, American Psychiatric Press, 1994.
28. Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M, Ferris S: An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997; 11(suppl 2):S33-S39.
29. Feldman HH, Schmitt FA, Olin JT; Group MM-M-S: Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment. Alzheimer Dis Assoc Disord 2006; 20: 263-268.
30. Wesnes KA, McKeith I, Edgar C, Emre M, Lane R: Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology 2005; 65: 1654-1656. (Pubitemid 41689487)
31. Wesnes K, Edgar C, O'Brien JT: Rivastigmine reduces the attentional deficit in dementia associated with Parkinson's disease and treatment response is dependent on the initial severity of the deficits. Int Psychogeriatr 2005; 17: 263-264.
32. Cifu DX, Carne W, Brown R, Pegg P, Ong J, Qutubuddin A, Baron MS: Caregiver distress in parkinsonism. J Rehabil Res Dev 2006; 43: 499-508.