High-dose N-acetylcysteine therapy for novel H1N1 influenza pneumonia

Annals of Internal Medicine

Volumn 152, Issue 10, 2010, Pages 687-688

  Lai, Kang Yiu ^a   Ng, Wing Yiu ^a   Chan, Pik Kei Osburga ^a   Wong, Kit Fai ^a   Cheng, Fanny ^a  

^a QUEEN ELIZABETH HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; C REACTIVE PROTEIN; CLARITHROMYCIN; HYDROCORTISONE; NITRIC OXIDE; NORADRENALIN; OSELTAMIVIR; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN; ANTIVIRUS AGENT;

ADULT; ARTIFICIAL VENTILATION; BLOOD OXYGEN TENSION; CASE REPORT; CONTINUOUS INFUSION; DRUG MEGADOSE; FEMALE; HUMAN; INFLUENZA A (H1N1); LETTER; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY FAILURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK; SMOKING; TREATMENT RESPONSE; VIRUS PNEUMONIA; DRUG COMBINATION; INFLUENZA; INFLUENZA VIRUS A H1N1; MIDDLE AGED;

ACETYLCYSTEINE; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MIDDLE AGED; PNEUMONIA, VIRAL;

EID: 77952963499     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-152-10-201005180-00017     Document Type: Letter

References (5)

1. Knobil K, Choi AMK, Weigand GW, Kacoby DB. Role of oxidants in influenza virus-induced gene expression. Am J Physiol Lung Cell Mol Physiol. 1998;274:L134-42.
2. Nimmerjahn F, Dudziak D, Dirmeier U, Hobom G, Riedel A, Schlee M, et al. Active NF-kappaB signalling is a prerequisite for influenza virus infection. J Gen Virol. 2004;85:2347-56. [PMID: 15269376]
3. Garozzo A, Tempera G, Ungheri D, Timpanaro R, Castro A. N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection. Int J Immunopathol Pharmacol. 2007;20:349-54. [PMID: 17624247] (Pubitemid 47104855)
4. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J. 1997;10:1535-41. [PMID: 9230243]
5. Kaiser L, Fritz RS, Straus SE, Gubareva L, Hayden FG. Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses. J Med Virol. 2001;64:262-8. [PMID: 11424113]