Genetics of patent foramen ovale-NKX2-5 and beyond

Clinical Neurology and Neurosurgery

Volumn 112, Issue 6, 2010, Pages 457-458

  Elliott, Graeme C ^a   Sargurupremraj, Muralidharan ^a   Velupandian, Uma ^b   Gurtu, Rockesh ^b   Trump, Dorothy ^a   Newman, William ^a   Wang, Tao ^a   McCollum, Charles ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Cryptogenic; Genetics; Genome wide association; Migraine; NKX2 5; Patent foramen ovale; Stroke; Varicose veins

Indexed keywords

TRANSCRIPTION FACTOR NKX2.5;

CEREBROVASCULAR ACCIDENT; DNA POLYMORPHISM; EXON; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; LETTER; MIGRAINE AURA; NUCLEOTIDE SEQUENCE; PATENT FORAMEN OVALE;

FORAMEN OVALE, PATENT; HOMEODOMAIN PROTEINS; HUMANS; MUTATION; TRANSCRIPTION FACTORS;

EID: 77952952541     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2010.03.005     Document Type: Letter

References (9)

1. Belvis R., Tizzano E.F., Marti-Fabregas J., Leta R.G., Baena M., Carreras F., et al. Mutations in the NKX2-5 gene in patients with stroke and patent foramen ovale. Clin Neurol Neurosurg 111 (2009) 574-578
2. Handke M., Harloff A., Olschewski M., Hetzel A., and Geibel A. Patent foramen ovale and cryptogenic stroke in older patients. N Engl J Med 357 (2007) 2262-2268
3. Schwerzmann M.M., Nedeltchev K.M., Lagger F.B., Mattle H.P.M., Windecker S.M., Meier B.M., et al. Prevalence and size of directly detected patent foramen ovale in migraine with aura. Neurology 65 (2005) 1415-1418
4. Kirk E.P., Hyun C., Thomson P.C., Lai D., Castro M.L., Biben C., et al. Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. Circ Res 98 (2006) 651-658
5. Wilmshurst P.T., Pearson M.J., Nightingale S., Walsh K.P., and Morrison W.L. Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura. Heart 90 (2004) 1315-1320
6. Wright D.D., Gibson K.D., Rush J.E., Barclay J., Razumovsky A., and McCollum C.N. High prevalence of right-to-left shunt in patients with symptomatic great saphenous incompetence and varicose veins. J. Vasc. Surg. 51 1 (2010) 104-107
7. Ng M.Y.M., Andrew T., Spector T.D., and Jeffery S. Linkage to the FOXC2 region of chromosome 16 for varicose veins in the otherwise healthy, unselected sibling pairs. J Med Genet 42 (2005) 235-239
8. Benson D.W., Silberbach G.M., Kavanaugh-McHugh A., Cottrill C., Zhang Y., Riggs S., et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J Clin Invest 104 (1999) 1567-1573
9. Sarkozy A., Conti E., Neri C., D'Agostino R., Digilio M.C., Esposito G., et al. Spectrum of atrial septal defects associated with mutations of NKX2.5 and GATA4 transcription factors. J Med Genet 42 (2005) e16