Naringenin chalcone improves adipocyte functions by enhancing adiponectin production

Molecular and Cellular Endocrinology

Volumn 323, Issue 2, 2010, Pages 208-214

  Horiba, Taro ^a   Nishimura, Ikuko ^a   Nakai, Yuji ^b   Abe, Keiko ^b   Sato, Ryuichiro ^b  

^a KIKKOMAN CORPORATION   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adipocyte; Adiponectin; DNA microarray; Naringenin chalcone

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 2; FLAVONOID; NARINGENIN CHALCONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; ADIPONECTIN RECEPTOR; ADIPONECTIN RECEPTOR 2, MOUSE; CHALCONE DERIVATIVE; HYBRID PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA MICROARRAY; DRUG MECHANISM; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; INSULIN SENSITIVITY; MITOCHONDRIAL ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; TOMATO; UPREGULATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHALCONES; GENE EXPRESSION; LYCOPERSICON ESCULENTUM; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PPAR GAMMA; RECEPTORS, ADIPONECTIN; RECOMBINANT FUSION PROTEINS; UP-REGULATION;

EID: 77952944681     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.03.020     Document Type: Article

References (43)

1. Arimura N., Horiba T., Imagawa M., Shimizu M., Sato R. The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. J. Biol. Chem. 2004, 279:10070-10076.
2. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. 1995, 57:289-300.
3. Breitling R., Armengaud P., Amtmann A., Herzyk P. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 2004, 573:83-92.
4. Chen Z., McGee M., Liu Q., Scheuermann R.H. A distribution free summarization method for Affymetrix GeneChip arrays. Bioinformatics 2007, 23:321-327.
5. Combs T.P., Wagner J.A., Berger J., Doebber T., Wang W.J., Zhang B.B., Tanen M., Berg A.H., O'Rahilly S., Savage D.B., Chatterjee K., Weiss S., Larson P.J., Gottesdiener K.M., Gertz B.J., Charron M.J., Scherer P.E., Moller D.E. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002, 143:998-1007.
6. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., Lempicki R.A. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 2003, 4:P3.
7. Diez J.J., Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. Endocrinol. 2003, 148:293-300.
8. Fasshauer M., Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia 2003, 46:1594-1603.
9. Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004, 53(Suppl. 1):S43-S50.
10. Galli A., Crabb D.W., Ceni E., Salzano R., Mello T., Svegliati-Baroni G., Ridolfi F., Trozzi L., Surrenti C., Casini A. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 2002, 122:1924-1940.
11. Gentleman R.C., Carey V.J., Bates D.M., Bolstad B., Dettling M., Dudoit S., Ellis B., Gautier L., Ge Y., Gentry J., Hornik K., Hothorn T., Huber W., Iacus S., Irizarry R., Leisch F., Li C., Maechler M., Rossini A.J., Sawitzki G., Smith C., Smyth G., Tierney L., Yang J.Y., Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004, 5:R80.
12. Hassan M., El Yazidi C., Landrier J.F., Lairon D., Margotat A., Amiot M.J. Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells. Biochem. Biophys. Res. Commun. 2007, 361:208-213.
13. Hirai S., Kim Y.I., Goto T., Kang M.S., Yoshimura M., Obata A., Yu R., Kawada T. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007, 81:1272-1279.
14. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
15. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4:44-57.
16. Ihaka R., Gentleman R. R: A language for data analysis and graphics. J. Comp. Graph. Stat. 1996, 5:299-314.
17. Iwaki M., Matsuda M., Maeda N., Funahashi T., Matsuzawa Y., Makishima M., Shimomura I. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003, 52:1655-1663.
18. Kanayama T., Arito M., So K., Hachimura S., Inoue J., Sato R. Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities. J. Biol. Chem. 2007, 282:10290-10298.
19. Kawai Y., Nishikawa T., Shiba Y., Saito S., Murota K., Shibata N., Kobayashi M., Kanayama M., Uchida K., Terao J. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J. Biol. Chem. 2008, 283:9424-9434.
20. Kelley D.E., He J., Menshikova E.V., Ritov V.B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002, 51:2944-2950.
21. Kunimasa K., Kuranuki S., Matsuura N., Iwasaki N., Ikeda M., Ito A., Sashida Y., Mimaki Y., Yano M., Sato M., Igarashi Y., Oikawa T. Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion. Bioorg. Med. Chem. Lett. 2009, 19:2062-2064.
22. Lazarus S.A., Bowen K., Garg M.L. Tomato juice and platelet aggregation in type 2 diabetes. JAMA 2004, 292:805-806.
23. Lehmann J.M., Moore L.B., Smith-Oliver T.A., Wilkison W.O., Willson T.M., Kliewer S.A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 1995, 270:12953-12956.
24. Li W., Tonelli J., Kishore P., Owen R., Goodman E., Scherer P.E., Hawkins M. Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle. Am. J. Physiol. Endocrinol. Metab. 2007, 292:E1301-E1307.
25. Liu B.H., Wang P.H., Wang Y.C., Cheng W.M., Mersmann H.J., Ding S.T. Fasting regulates the expression of adiponectin receptors in young growing pigs. J. Anim. Sci. 2008, 86:3377-3384.
26. Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett. 2006, 580:2917-2921.
27. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., Groop L.C. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 2003, 34:267-273.
28. Morino K., Petersen K.F., Dufour S., Befroy D., Frattini J., Shatzkes N., Neschen S., White M.F., Bilz S., Sono S., Pypaert M., Shulman G.I. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 2005, 115:3587-3593.
29. Muir S.R., Collins G.J., Robinson S., Hughes S., Bovy A., Ric De Vos C.H., van Tunen A.J., Verhoeyen M.E. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat. Biotechnol. 2001, 19:470-474.
30. Mustelin L., Pietilainen K.H., Rissanen A., Sovijarvi A.R., Piirila P., Naukkarinen J., Peltonen L., Kaprio J., Yki-Jarvinen H. Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E148-E154.
31. Pandey D.K., Shekelle R., Selwyn B.J., Tangney C., Stamler J. Dietary vitamin C and beta-carotene and risk of death in middle-aged men. The Western Electric Study. Am. J. Epidemiol. 1995, 142:1269-1278.
32. Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E.J., Goldfine A.B., Mun E., DeFronzo R., Finlayson J., Kahn C.R., Mandarino L.J. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:8466-8471.
33. Petersen K.F., Dufour S., Shulman G.I. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005, 2:e233.
34. Sartipy P., Loskutoff D.J. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:7265-7270.
35. Shimomura I., Funahashi T., Takahashi M., Maeda K., Kotani K., Nakamura T., Yamashita S., Miura M., Fukuda Y., Takemura K., Tokunaga K., Matsuzawa Y. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat. Med. 1996, 2:800-803.
36. Tsuchida A., Yamauchi T., Ito Y., Hada Y., Maki T., Takekawa S., Kamon J., Kobayashi M., Suzuki R., Hara K., Kubota N., Terauchi Y., Froguel P., Nakae J., Kasuga M., Accili D., Tobe K., Ueki K., Nagai R., Kadowaki T. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J. Biol. Chem. 2004, 279:30817-30822.
37. Wang Z., Masternak M.M., Al-Regaiey K.A., Bartke A. Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology 2007, 148:2845-2853.
38. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112:1796-1808.
39. Yamamoto T., Yoshimura M., Yamaguchi F., Kouchi T., Tsuji R., Saito M., Obata A., Kikuchi M. Anti-allergic activity of naringenin chalcone from a tomato skin extract. Biosci. Biotechnol. Biochem. 2004, 68:1706-1711.
40. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001, 7:941-946.
41. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y., Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
42. Yoshimura M., Sano A., Kamei J., Obata A. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J. Agric. Food Chem. 2009, 57:6432-6437.
43. Zhu M., Lee G.D., Ding L., Hu J., Qiu G., de Cabo R., Bernier M., Ingram D.K., Zou S. Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp. Gerontol. 2007, 42:733-744.