Variants of the mannose-binding lectin gene in the benin population: Heterozygosity for the p.G57E allele may confer a selective advantage

Human Biology

Volumn 81, Issue 5-6, 2009, Pages 899-909

  Dossou Yovo, Omer Placide ^a,b,c   Lapoumeroulie, Claudine ^a,b   Hauchecorne, Michelle ^a,b   Zaccaria, Isabelle ^a,d   Ducrocq, Rolande ^a,b   Krishnamoorthy, Rajagopal ^a,b   Rahimy, Mohamed Chérif ^c   Elion, Jacques ^a,b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF ABOMEY CALAVI   (Benin)

^d INSERM   (France)

Author keywords

Benin; HIV; Mannose binding lectin; MBL2; Meningitis; Selection; Sickle cell disease; Tuberculosis

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS;

MANNOSE BINDING LECTIN; MBL2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AFRICA; ANEMIA, SICKLE CELL; CHILD; FEMALE; GENETIC VARIATION; GENETICS; HETEROZYGOTE; HISTORY; HIV INFECTIONS; HUMAN; INCIDENCE; INFANT; MALE; MIDDLE AGED; MUTATION; POPULATION GENETICS; PRESCHOOL CHILD; PREVALENCE; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICA; ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC VARIATION; GENETICS, POPULATION; HETEROZYGOTE; HISTORY, 21ST CENTURY; HIV INFECTIONS; HUMANS; INCIDENCE; INFANT; MALE; MANNOSE-BINDING LECTIN; MIDDLE AGED; MUTATION; PREVALENCE; RISK FACTORS; YOUNG ADULT;

EID: 77952926856     PISSN: 00187143     EISSN: 15346617     Source Type: Journal    
DOI: 10.3378/027.081.0630     Document Type: Article

References (36)

1. Bellamy, R., C. Ruwende, K. P. McAdam et al. 1998. Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Q. J. Med. 91(1):13-18.
2. Bernig, T., J. G. Taylor, C. B. Foster et al. 2004. Sequence analysis of the mannose- binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection. Genes Immun. 5(6):461-476.
3. Boldt, A. B., A. Luty, M. P. Grobusch et al. 2006. Association of a new mannose- binding lectin variant with severe malaria in Gabonese children. Genes Immun. 7(5):393-400.
4. Ducrocq, R., O. Pascaud, A. Bevier et al. 2001. Strategy linking several analytical methods of neonatal screening for sickle cell disease. J. Med. Screen. 8(1):8-14.
5. Ezekowitz, R. A. 1998. Genetic heterogeneity of mannose- binding proteins: The Jekyll and Hyde of innate immunity? Am. J. Hum. Genet. 62(1):6-9.
6. Garred, P., M. Harboe, T. Oettinger et al. 1994. Dual role of mannan- binding protein in infections: Another case of heterosis? Eur. J. Immunogenet. 21(2):125-131.
7. Garred, P., H. O. Madsen, J. A. Kurtzhals et al. 1992. Diallelic polymorphism may explain variations of the blood concentration of mannan- binding protein in Eskimos but not in black Africans. Eur. J. Immunogenet. 19(6):403-412.
8. Garred, P., M. A. Nielsen, J. A. Kurtzhals et al. 2003. Mannose- binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum- infected erythrocytes. Infect. Immun. 71(9):5245-5253.
9. Garred, P., T. Pressler, H. O. Madsen et al. 1999. Association of mannose- binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J. Clin. Invest. 104(4):431-437.
10. Gill, F. M., L. A. Sleeper, S. J. Weiner et al. 1995. Clinical events in the first decade in a cohort of infants with sickle cell disease: Cooperative study of sickle cell disease. Blood 86(2):776-783.
11. Hibberd, M. L., M. Sumiya, J. A. Summerfield et al. 1999. Association of variants of the gene for mannose- binding lectin with susceptibility to meningococcal disease: Meningococcal Research Group. Lancet 353(9158):1049-1053.
12. Hoal- Van Helden, E. G., J. Epstein, T. C. Victor et al. 1999. Mannose- binding protein B allele confers protection against tuberculous meningitis. Pediatr. Res. 45(4, pt. 1):459-464.
13. Koch, A., M. Melbye, P. Sorensen et al. 2001. Acute respiratory tract infections and mannose- binding lectin insufficiency during early childhood. J. Am. Med. Assoc. 285(10):1316-1321.
14. Kristensen, I. A., S. Thiel, R. Steffensen et al. 2004. Mannan- binding lectin and RSV lower respiratory tract infection leading to hospitalization in children: A case- control study from Soweto, South Africa. Scand. J. Immunol. 60(1-2):184-188.
15. Lee, S. G., J. S. Yum, H. M. Moon et al. 2005. Analysis of mannose- binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population. Mol. Immunol. 42(8):969-977.
16. Lipscombe, R. J., M. Sumiya, A. V. Hill et al. 1992. High frequencies in African and non- African populations of independent mutations in the mannose binding protein gene. Hum. Mol. Genet. 1(9):709-715.
17. Lipscombe, R. J., M. Sumiya, J. A. Summerfield et al. 1995. Distinct physicochemical characteristics of human mannose binding protein expressed by individuals of differing genotype. Immunology 85(4):660-667.
18. Madsen, H. O., P. Garred, J. A. Kurtzhals et al. 1994. A new frequent allele is the missing link in the structural polymorphism of the human mannan- binding protein. Immunogenetics 40(1):37-44.
19. Madsen, H. O., P. Garred, S. Thiel et al. 1995. Interplay between promoter and structural gene variants control basal serum level of mannan- binding protein. J. Immunol. 155(6):3013-3020.
20. Madsen, H. O., M. L. Satz, B. Hogh et al. 1998. Different molecular events result in low protein levels of mannan- binding lectin in populations from southeast Africa and South America. J. Immunol. 161(6):3169-3175.
21. Matsushita, M., A. Takahashi, H. Hatsuse et al. 1992. Human mannose- binding protein is identical to a component of Ra- reactive factor. Biochem. Biophys. Res. Commun. 183(2):645-651.
22. Mombo, L. E., C. Y. Lu, S. Ossari et al. 2003. Mannose- binding lectin alleles in sub- Saharan Africans and relation with susceptibility to infections. Genes Immun. 4(5):362-367.
23. Neonato, M. G., C. Y. Lu, M. Guilloud- Bataille et al. 1999. Genetic polymorphism of the mannosebinding protein gene in children with sickle cell disease: Identification of three new variant alleles and relationship to infections. Eur. J. Hum. Genet. 7(6):679-686.
24. Peterslund, N. A., C. Koch, J. C. Jensenius et al. 2001. Association between deficiency of mannosebinding lectin and severe infections after chemotherapy. Lancet 358(9282):637-638.
25. Rahimy, M. C., A. Gangbo, G. Ahouignan et al. 1999. Outpatient management of fever in children with sickle cell disease (SCD) in an African setting. Am. J. Hematol. 62(1):1-6.
26. Santos, I. K., C. H. Costa, H. Krieger et al. 2001. Mannan- binding lectin enhances susceptibility to visceral leishmaniasis. Infect. Immun. 69(8):5212-5215.
27. Sastry, K., G. A. Herman, L. Day et al. 1989. The human mannose- binding protein gene: Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J. Exp. Med. 170(4):1175-1189.
28. Seyfarth, J., P. Garred, and H. O. Madsen. 2005. The " involution" of mannose- binding lectin. Hum. Mol. Genet. 14(19):2859-2869.
29. Sullivan, K. E., C. Wooten, D. Goldman et al. 1996. Mannose- binding protein genetic polymorphisms in black patients with systemic lupus erythematosus. Arthritis Rheum. 39(12):2046-2051.
30. Sumiya, M., M. Super, P. Tabona et al. 1991. Molecular basis of opsonic defect in immunodeficient children. Lancet 337(8757):1569-1570.
31. Summerfield, J. A., S. Ryder, M. Sumiya et al. 1995. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet 345(8954):886-889.
32. Van Hoeyveld, E., F. Houtmeyers, C. Massonet et al. 2004. Detection of single nucleotide polymorphisms in the mannose- binding lectin gene using minor groove binder- DNA probes. J. Immunol. Meth. 287(1-2):227-230.
33. Verdu, P., L. B. Barreiro, E. Patin et al. 2006. Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles. Hum. Mol. Genet. 15(17):2650-2658.
34. Walsh, E. C., P. Sabeti, H. B. Hutcheson et al. 2006. Searching for signals of evolutionary selection in 168 genes related to immune function. Hum. Genet. 119(1-2):92-102.
35. World Health Organization. 2005. Enhanced surveillance of epidemic meningococcal meningitis in Africa: A three- year experience. Weekly Epidemiol. Rec. 37(80):313-320. Available at http:// www.who.int/entity/wer/2005/wer8037
36. World Health Organization. 2006. Global Tuberculosis Control: Regional and Country Data-Africa. Available at http://www.who.int/tb/publications/global report/2006/pdf/afr.pdf