Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice

Planta Medica

Volumn 76, Issue 8, 2010, Pages 793-795

  Joh, Eun Ha ^a   Yang, Jeong Wha ^a   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Cucurbitaceae; Gynostemma pentaphyllum; Gypenoside LXXIV; Learning; Memory; Scopolamine

Indexed keywords

GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 3; GINSENOSIDE RG 5; GINSENOSIDE RH 2; GINSENOSIDE RK1; GYPENOSIDE; HERBACEOUS AGENT; SCOPOLAMINE; TACRINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DRUG APPROVAL; DRUG EFFICACY; DRUG ISOLATION; DRUG STRUCTURE; GINSENG; GYNOSTEMMA PENTAPHYLLUM; HERBAL MEDICINE; LEARNING; LEARNING DISORDER; MAZE TEST; MEMORY; MEMORY DISORDER; MOUSE; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE; PLANT ROOT; SCUTELLARIA BAICALENSIS; SWIMMING;

ANIMALS; GYNOSTEMMA; LEARNING DISORDERS; MALE; MAZE LEARNING; MICE; MICE, INBRED ICR; PLANT EXTRACTS; SCOPOLAMINE;

CUCURBITACEAE; GYNOSTEMMA PENTAPHYLLUM; MUS;

EID: 77952916776     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1240795     Document Type: Article

References (17)

1. Eikelenboom P, Zhan S S., van Gool W A., Allsop D. Inflammatory mechanisms in Alzheimer's disease. Trends Pharmacol Sci 1994 15 447-450
2. Whitehouse P J., Price D L., Clark A W., Coyle J T., DeLong M R. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981 10 122-126
3. Araujo J A., Studzinski C M., Milgram N W. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry 2005 29 411-422
4. Tariot P N., Patel S V., Cox C, Henderson R E. Age-related decline in central cholinergic function demonstrated with scopolamine. Psychopharmacology 1996 125 50-56
5. Doody R S. Clinical profile of donepezil in the treatment of Alzheimer's disease. Gerontology 1999 45 (Suppl.1) 23-32
6. Campbell M D., Jaques Jr S, Gala R R. The lack of an effect of cholinergic agonists on anterior pituitary prolactin production in vitro. Experientia 1978 34 1522-1523
7. Hu L, Chen Z, Xie Y. New triterpenoid saponins from Gynostemma pentaphyllum. J Nat Prod 1996 59 1143-1145 (Pubitemid 27026574)
8. la Cour B, Molgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 1995 46 125-129
9. Huang W C., Kuo M L., Li M L., Yang R C., Liou C J., Shen J J. Gynostemma pentaphyllum decreases allergic reactions in a murine asthmatic model. Am J Chin Med 2008 36 579-592
10. Lu K W., Tsai M L., Chen J C., Hsu S C., Hsia T C., Lin M W., Huang A C., Chang Y H., Ip S W., Lu H F., Chung J G. Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9. Anticancer Res 2008 28 1093-1099
11. Shang T, Cheng J, Qi J, Miao H. Scutellaria flavonoid reduced memory dysfunction and neuronal injury caused by permanent global ischemia in rats. Pharmacol Biochem Behav 2005 82 67-73
12. Rudadakewich M, Ba F, Benishin C G. Neutrophic and neuroprotective actions of ginsenoside Rb1 and Rg1. Planta Med 2001 67 533-537
13. Lee T F., Shiao Y J., Chen C F., Wang L C. Effect of ginseng saponins on beta-amyloid-suppressed acetylcholine release from rat hippocampal slices. Planta Med 2001 67 634-637
14. Bao H Y., Zhang J, Yeo S J., Myung C S., Kim H M., Kim J M., Park J H., Cho J, Kang J S. Memory enhancing and neuroprotective effects of selected ginsenosides. Arch Pharm Res 2005 28 335-342
15. Park E K., Choo M K., Oh J K., Ryu J H., Kim D H. Ginsenoside Rh2 reduces ischemic brain injury in rats. Biol Pharm Bull 2004 27 433-436
16. Yamaguchi Y, Higashi M, Kobayashi H. Effects of ginsenosides on impaired performance caused by scopolamine in rats. Eur J Pharmacol 1996 312 149-151
17. Yang J H., Han S J., Ryu J H., Jang I S., Kim D H. Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. Biol Pharm Bull 2009 32 1710-1715