A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding

Journal of Biological Chemistry

Volumn 285, Issue 23, 2010, Pages 17371-17379

  Dweck, David ^a   Reynaldo, Daniel P ^a   Pinto, Jose R ^a   Potter, James D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-ASE ACTIVITY; CARDIAC MUSCLES; CARDIAC TROPONIN; CARDIAC TROPONIN C; CONTRACTILE FORCE; DILATED CARDIOMYOPATHY; DILATED CARDIOMYOPATHY-CAUSING MUTATIONS; DOUBLE MUTATION; MUSCLE FIBER; SINGLE MUTANT; THIN FILAMENTS; TROPONIN; TROPONIN C; WILD TYPES;

BINDING ENERGY; BIOCHEMISTRY; CALCIUM; FILAMENTS (LAMP); HEART; MUSCLE; PROTEINS; STOICHIOMETRY;

BINDING SITES;

ACTIN; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; MYOSIN; TROPONIN C; TROPONIN T;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HEART MUSCLE CONTRACTILE FORCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ACTINS; ADENOSINE TRIPHOSPHATASES; ANIMALS; BINDING SITES; CALCIUM; CARDIOMYOPATHY, DILATED; ENZYME ACTIVATION; HUMANS; MUSCLE CONTRACTION; MUTATION; MYOSINS; PROTEIN BINDING; PROTEIN CONFORMATION; SWINE; TROPONIN C;

EID: 77952903869     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064105     Document Type: Article

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