Adverse drug reactions in hospital and ambulatory care settings identified using a large administrative database

Annals of Pharmacotherapy

Volumn 44, Issue 6, 2010, Pages 983-993

  Kane Gill, Sandra L ^a,b,c   Van Den Bos, Jill ^d   Handler, Steven M ^a,e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Center for Pharmacoinformatics and Outcomes Research   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d MILLIMAN INC   (United States)

^e GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

Adverse drug reaction reporting systems; Adverse drug reactions; Ambulatory care; Hospital administration; Safety; Safety management

Indexed keywords

ANALGESIC AGENT; ANTIALLERGIC AGENT; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIDIABETIC AGENT; ANTIEMETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIPYRETIC AGENT; ANTIRHEUMATIC AGENT; CARDIOTONIC AGENT; CARDIOVASCULAR AGENT; CEPHALOSPORIN DERIVATIVE; CORTICOSTEROID; DIURETIC AGENT; GLYCOSIDE; IMMUNOSUPPRESSIVE AGENT; INSULIN DERIVATIVE; NARCOTIC AGENT; OPIATE DERIVATIVE; PENICILLIN DERIVATIVE;

AMBULATORY CARE; ARTICLE; CARDIOVASCULAR DISEASE; COMORBIDITY; DATA BASE; DRUG SAFETY; ENDOCRINE DISEASE; HEALTH INSURANCE; HOSPITAL CARE; HOSPITAL PATIENT; HUMAN; MEDICARE; METABOLIC DISORDER; NUTRITIONAL DISORDER; PREVALENCE; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; ADVERSE DRUG REACTION REPORTING SYSTEMS; AGED; AGED, 80 AND OVER; AMBULATORY CARE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; DRUG TOXICITY; FEMALE; HOSPITAL ADMINISTRATION; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; YOUNG ADULT;

EID: 77952893656     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M726     Document Type: Article

References (50)

1. Lacoste-Roussillon C, Pouyanne P, Haramburu F, Miremont G, Begaud B. Incidence of serious adverse drug reactions in general practice: a prospective study. Clin Pharmacol Ther 2001;69:458-462 (Pubitemid 32554552)
2. Gurwitz JH, Field TS, Harrold LR, et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 2003;289:1107-1116
3. Honigman B, Lee J, Rothschild J, et al. Using computerized data to identify adverse drug events in outpatients. J Am Med Inform Assoc 2001;8: 254-266 (Pubitemid 32428753)
4. Aparasu RR. Visits to office-based physicians in the United States for medication-related morbidity. J Am Pharm Assoc 1999;39:332-337
5. Jha AK, Kuperman GJ, Teich JM, et al. Identifying adverse drug events: development of a computer-based monitor and comparison with chart review and stimulated voluntary report. J Am Med Inform Assoc 1998;5:305-314
6. Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events. Implications for prevention. JAMA 1995;274:29-34.
7. Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1997;277:301-306
8. Institute of Medicine. Preventing medication errors. Washington, DC: National Academies Press, 2007.
9. Aronson JK, Ferner RE. Clarification of terminology in drug safety. Drug Saf 2005;28:851-870
10. Kaushal R, Bates DW, Poon EG, Jha AK, Blumenthal D; Harvard Interfaculty Program for Health Systems Improvement NHIN Working Group. Functional gaps in attaining a national health information network. What will it take to get there in five years? Health Aff 2005;24:1281-1289
11. Kaushal R, Blumenthal D, Poon EG, et al. The costs of a national health information network. Ann Intern Med 2005;143:165-173 (Pubitemid 41076749)
12. Plews-Ogan ML, Nadkarni MM, Forren S, et al. Patient safety in the ambulatory setting. A clinician-based approach. J Gen Intern Med 2004;19:719-725 (Pubitemid 38951943)
13. Ghandi TK, Burstin HR, Cook EF, et al. Drug complications in outpatients. J Gen Intern Med 2000;15:149-154
14. Barker KN, Flynn EA, Pepper GA. Observation method of detecting medication errors. Am J Health Syst Pharm 2002;59:2314-2316
15. Murff HJ, Patel VL, Hripcsak G, Bates DW. Detecting adverse events for patient safety research: a review of current methodologies. J Biomed Inform 2003;36:131-143 (Pubitemid 37209987)
16. Stockwell D, Kane-Gill SL. Developing a patient safety surveillance system to prevent adverse drug events in the ICU. Crit Care Med 2010 (suppl) (in press).
17. Samore M, Evans RS, Lassen A, et al. Surveillance of medical device-related hazards and adverse events in hospitalized patients. JAMA 2004;291:325-370
18. Hougland P, Xu W, Pickard S, Masheter C, Williams SD. Performance of International Classification of Diseases, 9th Revision, Clinical Modification codes as an adverse drug event surveillance system. Med Care 2006;44:629-636 (Pubitemid 44284276)
19. Masheter CJ, Hougland P, Xu W. Advances in patient safety: from research to implementation. Volume 1: detection of inpatient health care associated injuries: comparing two ICD9CM code classifications. www.ahrq.gov/QUAL/advances (accessed 2010 Feb 19).
20. Hellinger FJ, Encinosa WE. Inappropriate drug combinations among privately insured patients with HIV disease. Med Care 2005;43(suppl 9):III53-62.
21. Zhao Y, Ash AS, Ellis RP, et al. Predicting pharmacy costs and other medical costs using diagnoses and drug claims. Med Care 2005;43:34-43. (Pubitemid 40137612)
22. International Classification of Diseases, 9th revision, Clinical Modification (ICD -9-CM). Los Angeles, CA: Practice Management Information Corporation, 2003.
23. Morimoto T, Gandhi TK, Seger AC, Hsieh TC, Bates DW. Adverse drug events and medication errors: detection and classification methods. Qual Saf Health Care 2004;13:306-314 (Pubitemid 39070900)
24. Boockvar KS, Liu S, Goldstein N, Nebeker J, Siu A, Fried T. Prescribing discrepancies likely to cause adverse drug events after patient transfer. Qual Saf Health Care 2009;18:32-36
25. Boockvar K, Fishman E, Kyracou CK, Monias A, Gavi S, Cortes T. Adverse events due to discontinuation in drug use and dose changes in patients transferred between acute and long-term care facilities. Arch Intern Med 2004;164:545-550 (Pubitemid 38314451)
26. Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Den S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc 2006;54:1516-1523
27. Raebel MA, Lyons EE, Andrade SE, et al. Laboratory monitoring of drugs at initiation of therapy in ambulatory care. J Gen Intern Med 2005;20:1120-1126 (Pubitemid 43110262)
28. Raebel MA, Carroll NM, Andrade SE, et al. Monitoring of drugs with a narrow therapeutic range in ambulatory care. Am J Manag Care 2006;12:268-274
29. Lassila HC, Stoehr GP, Ganguli M, et al. Use of prescription medications in an elderly rural population: the MoVIES Project. Ann Pharmacother 1996;30:589-595 (Pubitemid 26181698)
30. Bond CA, Raehl CL. Adverse drug reactions in United States hospitals. Pharmacotherapy 2006;26:601-608 (Pubitemid 43673042)
31. Field TS, Gurwitz JH, Harrold LR, et al. Risk factors for adverse drug events among older adults in ambulatory settings. J Am Geriatr Soc 2004;52:1349-1354 (Pubitemid 39038210)
32. Leape LL, Brennan TA, Laird N, et al. The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. N Engl J Med 1991;324:377-384
33. Pronovost P, Sexton B. Assessing safety culture: guidelines and recommendations. Qual Saf Health Care 2005;14:231-233 (Pubitemid 41133174)
34. Rask K, Culler S, Scott T, et al. Adopting National Quality Forum medication safe practices: progress and barriers to hospital implementation. J Hosp Med 2007;2:212-218 (Pubitemid 47377266)
35. Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. JAMA 1997;277:307-311 (Pubitemid 27045011)
36. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998;279:1200-1205 (Pubitemid 28193431)
37. Vargas E, Terleira A, Hernando F, et al. Effect of adverse drug reactions on length of stay in surgical intensive care units. Crit Care Med 2003;31:694-698 (Pubitemid 36379570)
38. Nuckols TK, Paddock SM, Bower AG, et al. Costs of intravenous adverse drug events in academic and nonacademic intensive care units. Med Care 2008;46:17-24.
39. Kane-Gill SL, Jacobi J, Rothschild JR. Adverse drug events in the ICU: risk factors, impact and role of team care. Crit Care Med 2010;(suppl) (in press).
40. Oderda GM, Said Q, Evans RS, et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother 2007;41:400-406 DOI 10.1345/aph.1H386
41. Yee JL, Hasson NK, Schreiber DH. Drug-related emergency department visits in an elderly veteran population. Ann Pharmacother 2005;39:1990-1995 DOI 10.1345/aph.1E541 (Pubitemid 41745941)
42. Field TS, Gilman BH, Subramanian S, Fuller JC, Bates DW, Gurwitz JH. The costs associated with adverse drug events in older adults in the ambulatory setting. Med Care 2005;43:1171-1176 (Pubitemid 43012173)
43. Institute of Medicine. Crossing the quality chasm: a new health system for the 21st century. Washington, DC: National Academy Press, 2001.
44. Federico F. Preventing harm from high-alert medications. Jt Comm J Qual Patient Saf 2007;33:537-542
45. Kuperman GJ, Bobb A, Payne TH, et al. Medication-related clinical decision support in computerized provider order entry systems: a review. J Am Med Inform Assoc 2007;14:29-40. (Pubitemid 44909484)
46. Evans RS, Pestotnik SL, Classen DC, Horn SD, Bass SB, Burke JP. Preventing adverse drug events in hospitalized patients. Ann Pharmacother 1994;28:523-527 (Pubitemid 24123771)
47. Rozich JD, Haraden CR, Resar RK. Adverse drug event trigger tool: a practical methodology for measuring medication related harm. Qual Saf Health Care 2003;12:194-200.
48. Kaboli PJ, Hoth AB, McClimon BJ, Schnipper JL. Clinical pharmacists and inpatient medical care: a systematic review. Arch Intern Med 2006;166:955-964
49. Osheroff JA, Teich JM, Middleton B, et al. A roadmap for national action on clinical decision support. J Am Med Inform Assoc 2007;14:141-145 (Pubitemid 46275496)
50. Strom BL. Data validity issues in using claims data. Pharmacoepidemiol Drug Saf 2001;10:389-392