Nitric oxide synthase immunolocalization and expression in the rat hippocampus after sub-acute lead acetate exposure in rats

Experimental and Toxicologic Pathology

Volumn 62, Issue 3, 2010, Pages 311-316

  Nava Ruíz, Concepción ^a,b   Alcaraz Zubeldia, Mireya ^c   Méndez Armenta, Marisela ^a   Vergara, Paula ^d   Díaz Ruìz, Araceli ^c   Ríos, Camilo ^c  

^a De Neurología y Neurocirugía   (Mexico)

^b NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^c UNIVERSIDAD AUTÓNOMA METROPOLITANA   (Mexico)

^d DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Hippocampus; Lead; Neurotoxicity; Nitric oxide; Nitric oxide synthase; Rats

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LEAD ACETATE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BRAIN LEVEL; CONTROLLED STUDY; ENZYME LOCALIZATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; LEAD BLOOD LEVEL; LEAD POISONING; MALE; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; NITRIC OXIDE SYNTHASE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ATOMIC;

RATTUS; RATTUS NORVEGICUS;

EID: 77952891871     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.04.006     Document Type: Article

References (30)

1. Adonaylo V.N., Oteiza P.I. Lead intoxication: antioxidants defenses damage in rat brain. Toxicology 1999, 135:77-85.
2. Altmann L., Weinsber F., Sveinsson K., Lilienthal H., Wiegand H., Winneke G. Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol Lett 1993, 66:105-112.
3. Antonio M.T., Copras I., Leret M.L. Neurochemical changes in new born rat's brain after gestational cadmium and lead exposure. Toxicol Lett 1999, 104:1-9.
4. Toxicological profile for lead 2005, Agency for Toxic Substance and Disease Register (ATSDR), US Department of Health and Humans Services, Public Health Service, Centres for Diseases Control, Atlanta, GA.
5. Bressler J.P., Goldstein G.W. Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991, 41:479-484.
6. Bridges C.C., Zalups R.K. Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 2005, 204:274-308.
7. Daniel S., Limson L.J., Dairam A., Watkins G.M., Daya S. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 2004, 98:266-275.
8. Doyle C.A., Slater P. Localization of neuronal and endothelial nitric oxide synthase isoforms in human hippocampus. Neuroscience 1997, 76:387-395.
9. García-Arenas G., Claudio L., Pérez-Severiano F., Ríos C. Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain. Toxicol Sci 1999, 50:244-284.
10. Garcia-Arenas G., Ramirez-Amaya V., Balderas I., Sandoval J., Escobar M.L., Rios C., Bermúdez-Rattoni F. Cognitive deficits in adult rats by lead intoxication are related with regional specific inhibition on cNOS. Behav Brain Res 2004, 149:49-59.
11. Goldstein W.G. Lead poisoning and brain cell function. Environ Health Perspect 1990, 89:91-94.
12. Glowinski J., Iversen L.L. Regional studies of catecholamines in the rat brain. J Neurochem 1966, 13:655-699.
13. Goyer R.A., Clarkson T.W. Toxic effects of metals. Casarett and Doull's, toxicology: the basic science of poisons 2001, 811-867. McGraw-Hill, New York. C.D. Klaassen (Ed.).
14. Hernández-Avila M., Romieu I., Rios C., Rivero A., Palazuelos E. Lead-glazed ceremics as major determinations of blood lead levels in Mexican women. Environ Health Perspect 1991, 94:117-120.
15. Jacoby S., Sims R.E., Hartell N.A. Nitric oxide is required for the induction of heterosynaptic spread of long-term potentiation in rat cerebellum slices. J Physiol 2001, 535:825-839.
16. Lasley S.M., Polan C., Armstrong D.L. Chronic exposure to environmental levels of lead impairs in vivo induction of long-term potentiation in rat hippocampal dentate. Brain Res 1993, 614:347-351.
17. Li H., Matsumoto K., Watanabe H. Different effects of unilateral and bilateral hippocampal lesions in rats on the performance of radial maze and odor-paired associate tasks. Brain Res Bull 1999, 48:113-119.
18. Li H., Wallareth T., Förstermann U. Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide 2002, 7:132-147.
19. Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
20. Miller D., Paschal D., Gunter E., Stroud P., D'Angelo J. Determination of lead in blood using electrothermal atomization atomic absoption spectrometry a l'vov plataform and matrix metabolism. Analyst 1987, 112:1701-1704.
21. Moncada S., Higgs A. The l-arginine-nitric oxide pathway. N Eng J Med 1993, 329:2002-2012.
22. Nathan C., Xie Q.W. Nitric oxide synthases: role, tolls and controls. Cell 1994, 78:915-918.
23. Papanikolaou N.C., Hatzidaki G.E., Belivanis S., Tzanakakis N.G., Tsatsakis M.A. Lead toxicity update. A brief review. Med Sci Monit 2005, 11:RA329-RA336.
24. 2+ -stimulated nitric oxide synthase activity from rat cerebellum. Neurosci Lett 1995, 196:65-68.
25. Sandhir R., Gill K.D. Effect of lead on the biological activity of calmodulin in rat brain. Exp Mol Pathol 1994, 61:69-75.
26. Selvin-Testa A., Capani F., Loidl F.C., Pecci-Saavedra J. The nitric oxide synthase expresión of rat cortical and hyppocampal neurons changes after early lead exposure. Neurosci Lett 1997, 236:75-78.
27. Snyder S.H. Nitric oxide: first a new class of neurotransmitters. Science 1992, 257:494-496.
28. Soltaninejad K., Kebriaeezadeh A., Minaiee B., Ostad N.S., Hosseini R., Azizi E., Abdollahi M. Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum Exp Toxicol 2003, 22:417-423.
29. Villeda-Hernández J., Barroso-Moguel R., Méndez-Armenta M., Nava-Ruíz C., Huerta-Romero R., Ríos C. Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate. Brain Res Bull 2001, 55:247-251.
30. Weaver J., Prasuphatana S., Tsai P., Cao G.L., Budzichowski T.A., Roman L.J., Rosen G.M. The activation of neuronal Nitric-oxide synthase by various divalent cations. J Pharmacol Exp Ther 2002, 302:781-786.