Protein microspheres for pulmonary drug delivery

Frontiers of Chemical Engineering in China

Volumn 4, Issue 1, 2010, Pages 82-86

  Sun, Yongda ^a  

^a Tianjin Crystec Pharmaceutical Technology Limited   (China)

Author keywords

Anti solvent process; Human recombinant insulin; Protein microsphere; Pulmonary drug delivery; Supercritical fluid

Indexed keywords

EID: 77952887093     PISSN: 16737369     EISSN: 16737474     Source Type: Journal    
DOI: 10.1007/s11705-009-0307-1     Document Type: Article

References (8)

1. Agu R U, Ugwoke MI, Armand M, Kinget R, Verbeke N. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respire Res, 2001, 2: 198-209.
2. York P, Kompella U B, Shekunov B Y, eds. Supercritical Fluid Technology for Drug Product Development, Series volume 138: Drugs and the Pharm Sci. USA: Marcel Dekker Inc, 2004.
3. Debenedetti P G, Lim G B, Prud'homme R K. European Patent EP 0542314; US Patent 6063910 priority 1991.
4. Thiering R, Dehghani F, Dillow A, Foster N R. Solvent effects on the controlled dense gas precipitation of model protein. J Chemical Technology & Biotechnology, 2000, 75: 42-53.
5. Hanna M H, York P, Rudd D, Beach S. A novel apparatus for controlled particle formation using supercritical fluids. Pharm Res, 1995, 12: S14; Patent PCT/GB95/01523.
6. Sievers R E, Karst U. European Patent 0677332, 1995; Us Patent 5639441, 1997.
7. Perrut M, Jung J, Leboeuf F. French patent application FR-0106403, priority 2001.
8. Sun Y D. Chinese patent application CN-200610015666. X, 2006 (in Chinese).