Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction

Neuroscience Letters

Volumn 476, Issue 3, 2010, Pages 127-132

  Leng, Yan ^a   Marinova, Zoya ^a   Reis Fernandes, Marcos A ^b   Nau, Heinz ^b   Chuang, De Maw ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Excitotoxicity; Glutamate; HDAC inhibitors; HSP70; Neuroprotection; Valproic acid

Indexed keywords

2 ETHYL 4 METHYL PENTANOIC ACID; 2 HEXYL 4 PENTYNOIC ACID; 2 PENTYL 4 PENTYNOIC ACID; GLUTAMIC ACID; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 1A; HEAT SHOCK PROTEIN 70 1B; HISTONE; HISTONE DEACETYLASE; MESSENGER RNA; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; VALPROIC ACID; VALPROIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; EXCITOTOXICITY; GENE EXPRESSION REGULATION; GRANULE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; UPREGULATION;

ACETYLATION; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; FATTY ACIDS, UNSATURATED; GLUTAMIC ACID; HISTONE DEACETYLASE INHIBITORS; HSP72 HEAT-SHOCK PROTEINS; NEUROPROTECTIVE AGENTS; RATS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; VALPROIC ACID;

EID: 77952885959     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.04.013     Document Type: Article

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