Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells

Food and Chemical Toxicology

Volumn 48, Issue 6, 2010, Pages 1741-1745

  Kim, Jeong Hwan ^a   Nam, Soo Wan ^a   Kim, Byung Woo ^a   Kim, Wun Jae ^b   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

Author keywords

Adipogenesis; Astaxanthin; Differentiation; Neural stem cells; Osteogenesis

Indexed keywords

ASTAXANTHIN; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; OSTEONECTIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; RETINOID X RECEPTOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL RENEWAL; CELL VIABILITY; CLONOGENESIS; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; GENE INDUCTION; GENE OVEREXPRESSION; MOUSE; NEURAL STEM CELL; NONHUMAN;

ADIPOCYTES; ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; MICE; NERVOUS SYSTEM; STEM CELLS; XANTHOPHYLLS;

EID: 77952880766     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.04.002     Document Type: Article

References (28)

1. Andrew A.G., Phaff H.J., Starr M.P. Carotenoids of Phaffia rhodozyma, a red pigmented fermenting yeast. Phytochemistry 1976, 15:1003-1007.
2. Bendich A., Olson J.A. Biological actions of carotenoides. FASEB J. 1989, 3:1927-1932.
3. Castro-Malaspina H., Gay R.E., Resnick G., Kapoor N., Meyers P., Chiarieri D., McKenzie S., Broxmeyer H.E., Moore M.A. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980, 56:289-301.
4. Gage F.H., Ray J., Fisher L.J. Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 1995, 18:159-192.
5. Gokhale P.J., Andrews P.W. Human embryonic stem cells: 10 years on. Lab. Invest. 2009, 89:259-262.
6. Goodell M.A. Stem-cell " plasticity": befuddled by the muddle. Curr. Opin. Hematol. 2003, 10:208-213.
7. Johnson E.A., An G.H. Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 1991, 11:297-326.
8. Johnson E.A., Schroeder W.A. Microbial carotenoids. Adv. Biochem. Eng. 1995, 53:119-178.
9. Jung J.U., Ko K., Lee D.H., Ko K., Chang K.T., Choo Y.K. The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells. Exp. Mol. Med. 2009, 41:935-945.
10. Jyonouchi H., Zhang L., Gross M., Tomita Y. Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens. Nutr. Cancer 1994, 21:47-58.
11. Jyonouchi H., Sun S., Lijima K., Gross M.D. Antitumor activity of astaxanthin and its mode of action. Nutr. Cancer 2000, 36:59-65.
12. Kim J.H., Chang H.I. High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using chemical and light induction. J. Microbiol. Biotechnol. 2006, 16:381-385.
13. Kim Y., Jeoung D. The cancer/testis antigen CAGE induces MMP-2 through the activation of NF-kappaB and AP-1. BMB Rep. 2009, 42:758-763.
14. Kim J.H., Choi S.K., Choi S.Y., Kim H.K., Chang H.I. Suppressive effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats. Biosci. Biotechnol. Biochem. 2005, 69:1300-1305.
15. Kim J.H., Kim Y.S., Song G.G., Park J.J., Chang H.I. Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats. Eur. J. Pharmacol. 2005, 514:53-59.
16. Kim J.H., Choi S.K., Park Y.S., Yun C.W., Cho D.W., Chee K.M., Chang H.I. Effect of culture conditions on astaxanthin formation in red yeast Xanthophyllomyces dendrorhous mutant JH1. J. Microbiol. Biotechnol. 2006, 16:438-442.
17. Kim J.H., Lee M.R., Kim J.H., Jee M.K., Kang S.K. Selenium induces improvement of stem cell behaviors in human adipose-tissue stromal cells via SAPK/JNK and stemness acting signals. Stem Cells 2008, 26:2724-2734.
18. Krinsky N.I. Antioxidant function of carotenoids. Free Radic. Biol. Med. 1989, 7:617-635.
19. Lui K.O., Waldmann H., Fairchild P.J. Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy. Curr. Stem Cell Res. Ther. 2009, 4:70-80.
20. Naguib Y.M. Antioxidant activities of astaxanthin and related carotenoids. J. Agric. Food Chem. 2000, 48:1150-1154.
21. Neuhuber B., Gallo G., Howard L., Kostura L., Mackay A., Fischer I. Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J. Neurosci. Res. 2004, 77:192-204.
22. Okai Y., Higashi-Okai K. Possible immunomodulating activities of carotenoids in in vitro cell culture experiments. Int. J. Immunopharmacol. 1996, 8:753-758.
23. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman A.M., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
24. Slack J.M. Stem cells in epithelial tissues. Science 2000, 287:1431-1433.
25. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:1-14.
26. Tanaka T., Morishita Y., Suzuki M., Kojima T., Okumura A., Mori H. Chemoprevension of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Carcinogenesis 1994, 15:15-19.
27. Tanaka T., Makita H., Ohnishi M., Mori H., Satoh A., Hara A. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin. Cancer Res. 1995, 55:4059-4064.
28. Wagers A.J., Weissman I.L. Plasticity of adult stem cells. Cell 2004, 116:639-648.