Is Urinary Sarcosine Useful to Identify Patients With Significant Prostate Cancer? The Trials and Tribulations of Biomarker Development

European Urology

Volumn 58, Issue 1, 2010, Pages 19-20

  Schalken, Jack A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BIOLOGICAL MARKER; CREATININE; PROSTATE SPECIFIC ANTIGEN; SARCOSINE;

CANCER GRADING; CANCER RESEARCH; CONSENSUS DEVELOPMENT; DIAGNOSTIC VALUE; DIGITAL RECTAL EXAMINATION; EDITORIAL; GAS CHROMATOGRAPHY; HEALTH CARE ORGANIZATION; HISTOPATHOLOGY; HUMAN; MALE; MASS SPECTROMETRY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROSTATE BIOPSY; PROSTATE CANCER; URINALYSIS;

HUMANS; MALE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; SARCOSINE; TUMOR MARKERS, BIOLOGICAL;

EID: 77952880618     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2010.02.025     Document Type: Editorial

References (5)

1. Sreekumar A., Poisson L.M., Rajendiran T.M., et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457 (2009) 910-914
2. Couzin J., and Biomarkers. Metabolite in urine may point to high-risk prostate cancer. Science 323 (2009) 865
3. Jentzmik F., Stephan C., Miller K., et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 58 (2010) 12-18
4. Hessels D., and Schalken J.A. The use of PCA3 in the diagnosis of prostate cancer. Nat Rev Urol 6 (2009) 255-261
5. Tomlins S.A., Bjartell A., Chinnaiyan A.M., et al. ETS gene fusions in prostate cancer: from discovery to daily clinical practice. Eur Urol 56 (2009) 275-286