Subchronic MK-801 treatment and post-weaning social isolation in rats: Differential effects on locomotor activity and hippocampal long-term potentiation

Behavioural Brain Research

Volumn 212, Issue 1, 2010, Pages 64-70

  Ashby, Donovan M ^a   Habib, Diala ^b   Dringenberg, Hans C ^a,b   Reynolds, James N ^a,b   Beninger, Richard J ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Locomotor activity; Long term potentiation; NMDA receptor; Schaffer

Indexed keywords

AMPHETAMINE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DRUG MECHANISM; GABAERGIC SYSTEM; HIPPOCAMPUS; IN VIVO STUDY; LOCOMOTION; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SOCIAL ISOLATION; SPRAGUE DAWLEY RAT; SYNAPSE;

AMPHETAMINE; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICS; CENTRAL NERVOUS SYSTEM STIMULANTS; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; FUNCTIONAL LATERALITY; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SOCIAL ISOLATION; TIME FACTORS;

EID: 77952879740     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.03.041     Document Type: Article

References (45)

1. Abdul-Monim Z., Neill J.C., Reynolds G.P. Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat. J Psychopharmacol 2007, 21:198-205.
2. Arrigoni E., Greene R.W. Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell. Br J Pharmacol 2004, 142:317-322.
3. Arvanov V.L., Wang R.Y. Clozapine, but not haloperidol, prevents the functional hyperactivity of n-methyl-d-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine. J Pharmacol Exp Ther 1999, 289:1000-1006.
4. Balla A., Sershen H., Serra M., Koneru R., Javitt D.C. Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release. Neuropsychopharmacology 2003, 28:34-44.
5. Benes F.M. Evidence for altered trisynaptic circuitry in schizophrenic hippocampus. Biol Psychiatry 1999, 46:589-599.
6. Benes F.M., Kwok E.W., Vincent S.L., Todtenkopf M.S. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 1998, 44:88-97.
7. Benes F.M., McSparren J., Bird E.D., SanGiovanni J.P., Vincent S.L. Deficits in small interneurons in prefrontal cortex and cingulated cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991, 48:996-1001.
8. Beninger R.J., Cooper T.A., Mazurski T.A. Automating the measurement of locomotor activity. Neurobehav Toxicol Teratol 1985, 7:79-85.
9. Beninger R.J., Forsyth J.K., Van Adel M., Reynolds J.N., Boegman R.J., Jhamandas K. Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061. Pharmacol Biochem Behav 2009, 91:495-502.
10. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993, 361:31-39.
11. Buck N., Cali S., Behr J. Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats. Neurosci Lett 2006, 392:5-9.
12. Dringenberg H.C., Kuo M.-C. Cholinergic, histaminergic, and noradrenergic regulation of LTP stability and induction threshold: cognitive implications. Neurotransmitter Interactions and Cognitive Function 2006, 165-183. Birkhäuser, Boston. E.D. Levin, L. Butcher, M. Decker (Eds.).
13. Fone K.C.F., Porkess M.V. Behavioural and neurochemical effects of post-weaning social isolation in rodents-Relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 2008, 32:1087-1102.
14. Goldner E.M., Hsu L., Waraich P., Somers J. Prevalence and incidence studies of schizophrenic disorders: a systematic review of the literature. Can J Psychiatry 2002, 47:833-843.
15. Grønli J., Murison R., Fiske E., Bjorvatn B., Sørensen E., Portas C.M., Ursin R. Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiol Behav 2005, 84:571-577.
16. Grunze H.C., Rainnie D.G., Hasselmo M.E., Barkai E., Hearn E.F., McCarley R.W., Greene R.W. NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci 1996, 16:2034-2043.
17. Habib D., Dringenberg H.C. Alternating low frequency stimulation of medial septal and commissural fibers induced NMDA-dependent, long-lasting potentiation of hippocampal synapses in urethane-anesthetized rats. Hippocampus 2009, 19:299-307.
18. Harrison P.J. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implication. Psychopharmacology 2004, 174:151-162.
19. Harte M.K., Powell S.B., Swerdlow N.R., Geyer M.A., Reynolds G.P. Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats. J Neural Transm 2007, 114:893-898.
20. Javitt D.C., Zukin S.R. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991, 148:1301-1308.
21. Jentsch J.D., Roth R.H. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1999, 20:201-225.
22. Jentsch J.D., Taylor J.R., Roth R.H. Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress and psychostimulant-induced hyperlocomotion. Neuropsychopharmacology 1998, 19:105-113.
23. Jentsch J.D., Tran A., Le D., Youngren K.D., Roth R.H. Subchronic phencyclidine administration reduces mesoprefrontal dopamine utilization and impairs prefrontal cortical-dependent cognition in the rat. Neuropsychopharmacology 1997, 17:92-99.
24. Lapiz M.D.S., Fulford A., Muchimapura S., Mason R., Parker T., Marsden C.A. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol 2003, 33:13-29.
25. Lee P.R., Brady D.L., Shapiro R.A., Dorsa D.M., Koenig J.I. Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin. Neuropsychopharmacology 2005, 30:1883-1894.
26. Leung L.S., Shen B., Rajakumar N., Ma J. Cholinergic activity enhances hippocampal long-term potentiation in CA1 during walking in rats. J Neurosci 2003, 23:9297-9304.
27. Lindahl J.S., Keifer J. Glutamate receptor subunits are altered in forebrain and cerebellum in rats chronically exposed to the NMDA receptor antagonist phencyclidine. Neuropsychopharmacology 2004, 29:2065-2073.
28. Lu L., Bao G., Chen H., Xia P., Fan X., Zhang J., Pei G., Ma L. Modification of hippocampal neurogenesis and neuroplasticity by social environments. Exp Neurol 2003, 183:600-609.
29. Manahan-Vaughan D., von Haebler D., Winter C., Juckel G., Heinemann U. A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats. Hippocampus 2008, 18:125-134.
30. Matthews D.B., Kralic L.E., Devaud L.L., Fritschy J., Leslie Morrow A.L. Chronic blockade of N-methyl-D-aspartate receptors alter g-aminobutyric acid type a receptor peptide expression and function in the rat. J Neurochem 2000, 74:1522-1528.
31. Meredith R.M., Floyer-Lea A.M., Paulsen O. Maturation of long-term potentiation induction rules in rodent hippocampus: role of GABAergic inhibition. J Neurosci 2003, 23:11142-11146.
32. Morris B.J., Cochran S.M., Pratt J.A. PCP: from pharmacology to modeling schizophrenia. Curr Opin Pharmacol 2005, 5:101-106.
33. Ninan I., Jardemark K.E., Wang R.Y. Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex. Neuropharmacology 2003, 44:462-472.
34. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego. 4th ed.
35. Pinault D. N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant γ oscillations in the rat neocortex. Biol Psychiatry 2008, 63:730-735.
36. Roberts L., Greene J.R.T. Post-weaning social isolation of rats leads to a diminution of LTP in the CA1 to subiculum pathway. Brain Res 2003, 991:271-273.
37. Rujescu D., Bender A., Keck M., Hartmann A.M., Ohl F., Raeder H., Giegling I., Genius J., McCarley R.W., Möller H.J., Grunze H. A pharmacological model for psychosis based on n-methyl-d-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities. Biol Psychiatry 2006, 59:721-729.
38. Snighda S., Neill J.C. Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats-a preliminary investigation. Behav Brain Res 2008, 187:489-494.
39. Uhlhaas P.J., Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 2010, 11:100-113.
40. Wang C., Showalter V.M., Hillman G.R., Johnson K.M. Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain. J Neurosci Res 1999, 55:762-769.
41. Wöhrl R., Eisenach S., Manahan-Vaughan D., Heinemann U., von Haebler D. Acute and long-term effects of MK-801 on direct cortical input evoked homosynaptic and heterosynaptic plasticity in the CA1 region of the female rat. Eur J Neurosci 2007, 26:2873-2883.
42. Xi D., Zhang W., Wang H.-X., Stradtman G.G., Gao W.-G. Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex. Int J Neuropsychopharmacol 2009, 12:1395-1408.
43. Yu B., Wang C., Liu J., Johnson K.M., Gallagher J.P. Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABAA synaptic receptors. Neuroscience 2002, 113:1-10.
44. Zhang Z.J., Reynolds G.P. A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia. Schizophr Res 2002, 55:1-10.
45. Zucker R.S., Regehr W.G. Short-term plasticity. Annu Rev Physiol 2002, 64:355-405.