KV1.3: A new therapeutic target to control vascular smooth muscle cell proliferation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 6, 2010, Pages 1073-1074

  Jackson, William F ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; POTASSIUM CHANNEL KCA3.1; POTASSIUM CHANNEL KV1.3; POTASSIUM ION; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CALCIUM TRANSPORT; CELL MIGRATION; CELL PROLIFERATION; DRUG TARGETING; EDITORIAL; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; GENOTYPE; HUMANS; HYPERPLASIA; KV1.3 POTASSIUM CHANNEL; MICE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; POTASSIUM CHANNEL BLOCKERS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; UP-REGULATION; VASCULAR DISEASES;

EID: 77952858578     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.206565     Document Type: Editorial

References (21)

1. Wonderlin WF, Strobl JS. Potassium channels, proliferation and G1 progression. J Membr Biol. 1996;154:91-107.
2. Neylon CB. Potassium channels and vascular proliferation. Vascul Pharmacol. 2002;38:35-41.
3. Pardo LA. Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda). 2004;19:285-292.
4. Miguel-Velado E, Moreno-Dominguez A, Colinas O, Cidad P, Heras M, Perez-Garcia MT, Lopez-Lopez JR. Contribution of Kv channels to phenotypic remodeling of human uterine artery smooth muscle cells. Circ Res. 2005;97:1280-1287.
5. Tharp DL, Bowles DK. The intermediate-conductance Ca2 +-activated K+ channel (KCa3.1) in vascular disease. Cardiovasc Hematol Agents Med Chem. 2009;7:1-11.
6. Tharp DL, Wamhoff BR, Turk JR, Bowles DK. Upregulation of intermediate-conductance Ca2 +-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle. Am J Physiol Heart Circ Physiol. 2006;291:H2493-H2503.
7. Kohler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kampfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003;108: 1119-1125.
8. Tharp DL, Wamhoff BR, Wulff H, Raman G, Cheong A, Bowles DK. Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis. Arterioscler Thromb Vasc Biol. 2008;28:1084-1089.
9. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008;118:3025-3037.
10. Cidad P, Moreno-Dominguez A, Novensa L, Roque M, Barquin L, Heras M, Perez-Garcia MT, Lopez-Lopez JR. Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010;30.
11. Cahalan MD, Chandy KG. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009;231:59-87.
12. Gotsman I, Sharpe AH, Lichtman AH. T-cell costimulation and coinhi-bition in atherosclerosis. Circ Res. 2008;103:1220-1231.
13. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci. 1999;54:B492-B501.
14. Jackson WF. Potassium channels in the peripheral microcirculation. Microcirculation. 2005;12:113-127.
15. Jackson WF. Potassium channels and proliferation of vascular smooth muscle cells. Circ Res. 2005;97:1211-1212.
16. Lallet-Daher H, Roudbaraki M, Bavencoffe A, Mariot P, Gackiere F, Bidaux G, Urbain R, Gosset P, Delcourt P, Fleurisse L, Slomianny C, Dewailly E, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N. Intermediate-conductance Ca2 +-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene. 2009;28:1792-1806.
17. Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev. 2009;89:193-277.
18. Lang F, Foller M, Lang K, Lang P, Ritter M, Vereninov A, Szabo I, Huber SM, Gulbins E. Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol. 2007;428:209-225.
19. Schwab A, Hanley P, Fabian A, Stock C. Potassium channels keep mobile cells on the go. Physiology (Bethesda). 2008;23:212-220.
20. Levite M, Cahalon L, Peretz A, Hershkoviz R, Sobko A, Ariel A, Desai R, Attali B, Lider O. Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. J Exp Med. 2000;191:1167-1176.
21. Artym VV, Petty HR. Molecular proximity of Kv1.3 voltage-gated potassium channels and beta(1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers. J Gen Physiol. 2002;120:29-37.