Evaluation of subharmonic emission from encapsulated microbubbles as an indicator for sonoporation of cell monolayers

Proceedings - IEEE Ultrasonics Symposium

Volumn , Issue , 2009, Pages 19-22

  Hensel, K ^a   Haagen, R ^a   Schmitz, G ^a   Maghnouj, A ^a   Hahn, S A ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Drug delivery; Sonoporation; Subharmonic emission; Therapy; Ultrasound contrast agents

Indexed keywords

CELLS; CONTAINERS; DRUG DELIVERY; EFFICIENCY; FLUORESCENCE; MONOLAYERS; TRANSDUCERS; ULTRASONICS;

FLUORESCENCE INTENSITIES; FLUORESCENCE PROPERTIES; LARGE SCALE OSCILLATIONS; SINGLE ELEMENT TRANSDUCERS; SONOPORATION; SUBHARMONIC EMISSIONS; THERAPY; ULTRASOUND CONTRAST AGENT;

CYTOLOGY;

EID: 77952837386     PISSN: 10510117     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ULTSYM.2009.5441709     Document Type: Conference Paper

References (14)

1. C. M. H. Newman and T. Bettinger, "Gene Therapy Progress And Prospects: Ultrasound For Gene Transfer," Gene Therapy, vol. 14, pp. 465-475, 2007.
2. R. Karshafian, P. Bevan, and P. Burns, .,Ultrasound-Induced Uptake of Different Size Markers in Mammalian Cells," 2005 IEEE Ultrasonics Symposium, vol. 1, pp. 13-16, 2005.
3. K. Hensel, M. Siepmann, A. Maghnouj, S. A. Hahn, and G. Schmitz, "Monitoring and Modeling of Microbubble Behavior during Ultrasound Mediated Transfection of Cell Monolayers," in Proc IEEE International Ultrasonics Symposium, pp 1671-1674, 2008.
4. K. Hensel, M. Siepmann, K. Haendschke, S. Emmelmann, A. Daigeler, J. Hauser, and G. Schmitz, "Monitoring of Insonicated Microbubble Behavior and their Effect on Sonoporation Supported Chemotherapy of Fibrosarcoma Cells," in IFMBE Proceedings. vol. 22, pp. 1422-1425. 2008
5. M. M. Forbes and J. William D. O'Brien, "The Role of Inertial Cavitation of Ultrasound Constrast Agents in Producing Sonoporation," in Proceedings of the 2007 IEEE Ultrasonics Symposium, pp. 424-427, 2007.
6. D. M. Hallow, A. D. Mahajan, T. E. McCutchen, and M. R. Prausnitz, "Measurement and Correlation of Acoustic Cavitation with Cellular Bioeffects," Ultrasound Med Biol, vol. 32, pp. 1111-1122, 2006.
7. E. Biagi, L. Breschi, E. Vannacci, and L. Masotti, "Subharmonic Emissions from Microbubbles: Effect of the Driving Pulse Shape," TUFFC, vol. 53, pp. 2174-2180, 2006.
8. K. Cheung, O. Couture, P. D. Bevan, E. Cherin, R. Williams, P. N. Burns, and F. S. Foster, "In vitro characterization of the subharmonic ultrasound signal from Definity microbubbles at high frequencies," Physics in Medicine and Biology, vol. 53, p. 1209-1223, 2008.
9. K. I. Morton, G. R. T. Haar, I. J. Stratford, and C. R. Hill, .,Subharmonic emission as an indicator of ultrasonically-induced biological damage," Ultrasound Med Biol, vol. 9, pp. 629-633, 1983.
10. D. L. Miller and S. Bao, "The relationship of scattered subharmonic, 3.3-MHz fundamental and second harmonic signals to damage of monolayer cells by ultrasonically activated Albunex® ," The Journal of the Acoustical Society of America, vol. 103, pp. 1183-1189, 1998.
11. A. van Wamel, K. Kooimann, M. Harteveld, M. Emmer, F. J. ten Cate, M. Versluis, and N. De Jong, "Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation," J. Controlled Release, vol. 112, pp. 149-155, 2006.
12. M.-X. Tang and R. J. Eckersley, "Nonlinear Propagation of Ultrasound Through Microbubble Contrast Agents and Implications for Imaging," IEEE Trans Ultrason Ferroelectr Freq Control, vol. 53, pp. 1406-1415, 2006.
13. M.-X. Tang and R. J. Eckersley, "Frequency and pressure dependent attenuation and scattering by microbubbles," Ultrasound Med Biol, vol. 33, pp. 164-168, 2007.
14. A. Eller and H. G. Flynn, .,Generation of Subharmonics of Order One-Half by Bubbles in a Sound Field," J Acoust Soc Am, vol. 46, pp. 722-727, 1969.