Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinoma

Head and Neck

Volumn 32, Issue 6, 2010, Pages 757-762

  Hinojar Gutiérrez, Adolfo ^a   Fernández Contreras, María Encarnación ^a,b   Álvarez Carrillo, Solssireé ^a   Quintanilla, Miguel ^c   Gamallo, Carlos ^a,b  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Intratumoral lymphatic vessels; Larynx cancer; Lymph node metastasis

Indexed keywords

PODOPLANIN;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HYPOPHARYNX CARCINOMA; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL ENDOTHELIUM; MAJOR CLINICAL STUDY; MALE; MICROCIRCULATION; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SQUAMOUS CELL CARCINOMA; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; LYMPH NODES; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHARYNGEAL NEOPLASMS;

EID: 77952774530     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21249     Document Type: Article

References (39)

1. Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin 2004;54:8-29.
2. Ferlay J, Bray F, Sankila R, Parkin DM. EUCAN: cancer incidence, mortality and prevalence in the European Union, version 4.0. IARC Cancer Base No. 4. Lyon: IARC Press.
3. Maula SM, Luukkaa M, Grénman R, Jackson D, Jalkanen S, Ristamäki R. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 2003;63:1920-1926. (Pubitemid 36460859)
4. Almadori G, Bussu F, Cadoni G, Galli J, Paludetti G, Maurizi M. Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach. Eur J Cancer 2005;41:683-693. (Pubitemid 40342550)
5. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. TNM, 6th ed. New York: Springer-Verlag; 2002.
6. Martín-Villar E, Scholl FG, Gamallo C, et al. Characterization of human PA2.26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer 2005;113:899-910. (Pubitemid 40096869)
7. Hinojar-Gutiérrez A, Fernández-Contreras ME, Gonzá - lez-González R, et al. Intratumoral lymphatic vessels and VEGF-C expression are predictive factors of lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma. Ann Surg Oncol 2007;14:248-257.
8. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
9. Takes RP, Baatenburg de Jong RJ, Schuuring E, et al. Markers for assessment of nodal metastasis in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 1997;123:412-419.
10. Cappellari JO. Histopathology and pathologic prognostic indicators. Otolaryngol Clin North Am 1997;30:251-268.
11. Pepper MS. Lymphangiogenesis and tumour metastasis: myth or reality. Clin Cancer Res 2001;7:462-468.
12. Sleeman JP. The lymph node as a bridgehead in the metastatic dissemination of tumours. Recent Results Cancer Res 2000;157:55-81.
13. He Y, Kerpanen T, Alitalo K. Role of lymphangiogenic factors in tumour metastasis. Biochim Biophys Acta 2004;1654:3-12.
14. Nathanson SD. Insights into the mechanisms of lymph node metastasis. Cancer 2003;98:413-423.
15. Jussila L, Valtola R, Partanen TA, et al. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. Cancer Res 1998;58:1599-1604.
16. Kaipainen A, Korhonen J, Mustonen T, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A 1995;92:3566-3570.
17. Partanen TA, Arola J, Saaristo A, et al. VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues. FASEB J 2000;14:2087-2096.
18. Valtola R, Salven P, Heikkila P, et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am J Pathol 1999;154:1381-1390.
19. Jussila L, Alitalo K. Vascular growth factors and lymphangiogenesis. Physiol Rev 2002;82:673-700.
20. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999;154:385-394.
21. Wigle JT, Oliver G. Prox 1 function is required for the development of the murine lymphatic system. Cell 1999;98:769-778.
22. Stacker SA, Baldwin ME, Achen MG. The role of tumour lymphangiogenesis in metastatic spread. FASEB J 2002;16:922-934.
23. Carreira CM, Nasser SM, di Tomaso E, et al. LYVE-1 is not restricted to the lymph vessels expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res 2001;61:8079-8084.
24. Banerji S, Ni J, Wang SX, et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 1999;144:789-801.
25. Khan HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumours. Lab Invest 2002;82:1255-1257. (Pubitemid 35014860)
26. Muñoz-Guerra MF, Marazuela EG, Martín-Villar E, Quintanilla M, Gamallo C. Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral cavity. A study of the early stages. Cancer 2004;100:553-600.
27. Scholl FG, Gamallo C, Vilaró S, Quintanilla M. Identification of PA2.26 antigen as a novel cell-surface mucintype glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. J Cell Sci 1999;112:4601-4613. (Pubitemid 30034809)
28. Rishi AK, Joyce-Brady M, Fisher J, et al. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol 1995;167:294-306.
29. Breiteneder-Geleff S, Matsui K, Soleiman A, et al. Podoplanin, novel 43-kD membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol 1997;151:1141-1152. (Pubitemid 27424324)
30. Evangelou E, Kyzas PA, Trikalinos TA. Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach. Mod Pathol 2005;18:1490-1497. (Pubitemid 41509404)
31. Cassella M, Skobe M. Lymphatic vessel activation cancer. Ann N Y Acad Sci 2002;979:120-130.
32. Padera TP, Kadambi A, di Tomaso E, et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002;296:1883-1886. (Pubitemid 34596277)
33. Jain RK, Fenton BT. Intratumoral lymphatic vessels: a case of mistaken identity or malfunction? J Natl Cancer Inst 2002;94:417-421.
34. Kyzas PA, Geleff S, Batistatou A, Agnantis NJ, Stefanou D. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 2005;206:170-177. (Pubitemid 40754020)
35. Beasley NJP, Prevo R, Banerji S, et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 2002;62:1315-1320. (Pubitemid 34407785)
36. Hall FT, Freeman JL, Asa SL, Jackson DG, Beasley NJ. Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 2003;129:716-719. (Pubitemid 36858956)
37. Massi D, Puig S, Franchi A, et al. Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study. J Clin Pathol 2006;59:166-173. (Pubitemid 43235582)
38. Miyata Y, Kanda S, Ohba K, et al. Tumour lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis. J Urol 2006;176:348-353. (Pubitemid 43815391)
39. Patel SG, Shah JP. TNM staging of cancers of the head and neck: striving for uniformity among diversity. CA Cancer J Clin 2005;55:242-258.