-
1
-
-
68949164754
-
Phospholipase D in endocytosis and endosomal recycling pathways
-
Donaldson J.G. Phospholipase D in endocytosis and endosomal recycling pathways. Biochim. Biophys. Acta 1791 (2009) 845-849
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 845-849
-
-
Donaldson, J.G.1
-
2
-
-
68949103681
-
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells
-
Foster D.A. Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochem. Biophys. Acta 1791 (2009) 949-955
-
(2009)
Biochem. Biophys. Acta
, vol.1791
, pp. 949-955
-
-
Foster, D.A.1
-
3
-
-
68949083047
-
The roles of phospholipase D in EGFR signaling
-
Lee C.S., Kim K.L., Jang J.H., Choi Y.S., Suh P.G., and Ryu S.H. The roles of phospholipase D in EGFR signaling. Biochim. Biophys. Acta 1791 (2009) 862-868
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 862-868
-
-
Lee, C.S.1
Kim, K.L.2
Jang, J.H.3
Choi, Y.S.4
Suh, P.G.5
Ryu, S.H.6
-
4
-
-
54149107123
-
mTOR signaling: PLD takes center stage
-
Sun Y., and Chen J. mTOR signaling: PLD takes center stage. Cell Cycle 7 (2008) 3118-3123
-
(2008)
Cell Cycle
, vol.7
, pp. 3118-3123
-
-
Sun, Y.1
Chen, J.2
-
5
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 (2007) 9-22
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
6
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y., Peterson T.R., Shaul Y.D., Lindquist R.A., Thoreen C.C., Bar-Peled L., and Sabatini D.M. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320 (2008) 1496-1501
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
7
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., and Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 (2008) 214-226
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
8
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., Yang Q., Bennett C., Harada Y., Stankunas K., Wang C.Y., He X., MacDougald O.A., You M., Williams B.O., and Guan K.L. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126 (2006) 955-968
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
Wang, C.Y.11
He, X.12
MacDougald, O.A.13
You, M.14
Williams, B.O.15
Guan, K.L.16
-
9
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning B.D., and Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 129 (2007) 1261-1274
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
10
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., and Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110 (2002) 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
11
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., and Sabatini D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14 (2004) 1296-1302
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
12
-
-
33747819801
-
mTOR and cancer: insights into a complex relationship
-
Sabatini D.M. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6 (2006) 729-734
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
13
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D.D., Ali S.M., Sengupta S., Sheen J.H., Hsu P.P., Bagley A.F., Markhard A.L., and Sabatini D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22 (2006) 159-168
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
14
-
-
62849111751
-
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
-
Toschi A., Lee E., Xu L., Garcia A., Gadir N., and Foster D.A. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol. Cell. Biol. 29 (2009) 1411-1420
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1411-1420
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.A.6
-
15
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang Y., Vilella-Bach M., Bachmann R., Flanigan A., and Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294 (2001) 1942-1945
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
16
-
-
38549134335
-
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
-
Veverka V., Crabbe T., Bird I., Lennie G., Muskett F.W., Taylor R.J., and Carr M.D. Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 27 (2008) 585-595
-
(2008)
Oncogene
, vol.27
, pp. 585-595
-
-
Veverka, V.1
Crabbe, T.2
Bird, I.3
Lennie, G.4
Muskett, F.W.5
Taylor, R.J.6
Carr, M.D.7
-
17
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
18
-
-
2942716838
-
Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53
-
Hui L., Abbas T., Pielak R.M., Joseph T., Bargonetti J., and Foster D.A. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol. Cell. Biol. 24 (2004) 5677-5686
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5677-5686
-
-
Hui, L.1
Abbas, T.2
Pielak, R.M.3
Joseph, T.4
Bargonetti, J.5
Foster, D.A.6
-
19
-
-
0033552613
-
Regulation of p53 stability
-
Ashcroft M., and Vousden K.H. Regulation of p53 stability. Oncogene 18 (1999) 7637-7643
-
(1999)
Oncogene
, vol.18
, pp. 7637-7643
-
-
Ashcroft, M.1
Vousden, K.H.2
-
21
-
-
0033959744
-
MDM2-master regulator of the p53 tumor suppressor protein
-
Momand J., Wu H.H., and Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene 242 (2000) 15-29
-
(2000)
Gene
, vol.242
, pp. 15-29
-
-
Momand, J.1
Wu, H.H.2
Dasgupta, G.3
-
22
-
-
85047700501
-
Phosphorylation of HDM2 by Akt
-
Ashcroft M., Ludwig R.L., Woods D.B., Copeland T.D., Weber H.O., MacRae E.J., and Vousden K.H. Phosphorylation of HDM2 by Akt. Oncogene 21 (2002) 1955-1962
-
(2002)
Oncogene
, vol.21
, pp. 1955-1962
-
-
Ashcroft, M.1
Ludwig, R.L.2
Woods, D.B.3
Copeland, T.D.4
Weber, H.O.5
MacRae, E.J.6
Vousden, K.H.7
-
23
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil D.P., Park J., and Hemmings B.A. PKB binding proteins. Getting in on the Akt. Cell 111 (2002) 293-303
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
24
-
-
42549109144
-
HIFα expression in VHL-deficient renal cancer cells is dependent on phospholipase D
-
Toschi A., Edelstein J., Rockwell P., Ohh M., and Foster D.A. HIFα expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene 27 (2008) 2746-2753
-
(2008)
Oncogene
, vol.27
, pp. 2746-2753
-
-
Toschi, A.1
Edelstein, J.2
Rockwell, P.3
Ohh, M.4
Foster, D.A.5
-
25
-
-
23344447873
-
Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance
-
Kulikov R., Boehme K.A., and Blattner C. Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Mol. Cell. Biol. 25 (2005) 7170-7180
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7170-7180
-
-
Kulikov, R.1
Boehme, K.A.2
Blattner, C.3
-
26
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo L.D., and Donner D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98 (2001) 11598-11603
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
27
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
Zhou B.P., Liao Y., Xia W., Zou Y., Spohn B., and Hung M.C. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3 (2001) 973-982
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.C.6
-
28
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
-
Toschi A., Lee E., Gadir N., Ohh M., and Foster D.A. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J. Biol. Chem. 283 (2008) 34495-34499
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
Ohh, M.4
Foster, D.A.5
-
29
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez J.M., and Alessi D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416 (2008) 375-385
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
30
-
-
70849085548
-
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
-
Amato R., D'Antona L., Porciatti G., Agosti V., Menniti M., Rinaldo C., Costa N., Bellacchio E., Mattarocci S., Fuiano G., Soddu S., Paggi M.G., Lang F., and Perrotti N. Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation. J. Mol. Med. 87 (2009) 1221-1239
-
(2009)
J. Mol. Med.
, vol.87
, pp. 1221-1239
-
-
Amato, R.1
D'Antona, L.2
Porciatti, G.3
Agosti, V.4
Menniti, M.5
Rinaldo, C.6
Costa, N.7
Bellacchio, E.8
Mattarocci, S.9
Fuiano, G.10
Soddu, S.11
Paggi, M.G.12
Lang, F.13
Perrotti, N.14
-
31
-
-
77952565472
-
mTOR complex-2 activates ENaC by phosphorylating SGK1
-
Lu M., Wang J., Jones K.T., Ives H.E., Feldman M.E., Yao L.J., Shokat K.M., Ashrafi K., and Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J. Am. Soc. Nephrol. 21 (2010) 811-818
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 811-818
-
-
Lu, M.1
Wang, J.2
Jones, K.T.3
Ives, H.E.4
Feldman, M.E.5
Yao, L.J.6
Shokat, K.M.7
Ashrafi, K.8
Pearce, D.9
-
32
-
-
33749500123
-
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms
-
Lang F., Bohmer C., Palmada M., Seebohm G., Strutz-Seebohm N., and Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol. Rev. 86 (2006) 1151-1178
-
(2006)
Physiol. Rev.
, vol.86
, pp. 1151-1178
-
-
Lang, F.1
Bohmer, C.2
Palmada, M.3
Seebohm, G.4
Strutz-Seebohm, N.5
Vallon, V.6
-
33
-
-
33646060747
-
Sgk kinases and their role in epithelial transport
-
Loffing J., Flores S.Y., and Staub O. Sgk kinases and their role in epithelial transport. Annu. Rev. Physiol. 68 (2006) 461-490
-
(2006)
Annu. Rev. Physiol.
, vol.68
, pp. 461-490
-
-
Loffing, J.1
Flores, S.Y.2
Staub, O.3
-
34
-
-
58949084058
-
mTORC2 is the hydrophobic motif kinase for SGK1
-
Yan L., Mieulet V., and Lamb R.F. mTORC2 is the hydrophobic motif kinase for SGK1. Biochem. J. 416 (2008) e19-e21
-
(2008)
Biochem. J.
, vol.416
-
-
Yan, L.1
Mieulet, V.2
Lamb, R.F.3
-
36
-
-
34447330960
-
IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells
-
Amato R., Menniti M., Agosti V., Boito R., Costa N., Bond H.M., Barbieri V., Tagliaferri P., Venuta S., and Perrotti N. IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells. J. Mol. Med. 85 (2007) 707-721
-
(2007)
J. Mol. Med.
, vol.85
, pp. 707-721
-
-
Amato, R.1
Menniti, M.2
Agosti, V.3
Boito, R.4
Costa, N.5
Bond, H.M.6
Barbieri, V.7
Tagliaferri, P.8
Venuta, S.9
Perrotti, N.10
-
37
-
-
44949201143
-
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
-
Hong F., Larrea M.D., Doughty C., Kwiatkowski D.J., Squillace R., and Slingerland J.M. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol. Cell 30 (2008) 701-711
-
(2008)
Mol. Cell
, vol.30
, pp. 701-711
-
-
Hong, F.1
Larrea, M.D.2
Doughty, C.3
Kwiatkowski, D.J.4
Squillace, R.5
Slingerland, J.M.6
-
38
-
-
69249219304
-
Relative resistance of SGK1 knockout mice against chemical carcinogenesis
-
Nasir O., Wang K., Foller M., Gu S., Bhandaru M., Ackermann T.F., Boini K.M., Mack A., Klingel K., Amato R., Perrotti N., Kuhl D., Behrens J., Stournaras C., and Lang F. Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB Life 61 (2009) 768-776
-
(2009)
IUBMB Life
, vol.61
, pp. 768-776
-
-
Nasir, O.1
Wang, K.2
Foller, M.3
Gu, S.4
Bhandaru, M.5
Ackermann, T.F.6
Boini, K.M.7
Mack, A.8
Klingel, K.9
Amato, R.10
Perrotti, N.11
Kuhl, D.12
Behrens, J.13
Stournaras, C.14
Lang, F.15
-
39
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan K.M., Barbie D.A., Davies M.A., Rabinovsky R., McNear C.J., Kim J.J., Hennessy B.T., Tseng H., Pochanard P., Kim S.Y., Dunn I.F., Schinzel A.C., Sandy P., Hoersch S., Sheng Q., Gupta P.B., Boehm J.S., Reiling J.H., Silver S., Lu Y., Stemke-Hale K., Dutta B., Joy C., Sahin A.A., Gonzalez-Angulo A.M., Lluch A., Rameh L.E., Jacks T., Root D.E., Lander E.S., Mills G.B., Hahn W.C., Sellers W.R., and Garraway L.A. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16 (2009) 21-32
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
40
-
-
46149088441
-
mTOR and signaling in cancer: SGK cycles in
-
Toker A. mTOR and signaling in cancer: SGK cycles in. Mol. Cell 31 (2008) 6-8
-
(2008)
Mol. Cell
, vol.31
, pp. 6-8
-
-
Toker, A.1
|