High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study

Nutrition

Volumn 26, Issue 6, 2010, Pages 634-640

  Manzanares, William ^a   Biestro, Alberto ^a   Galusso, Federico ^a   Torre, María H ^b   Mañáy, Nelly ^b   Facchin, Gianella ^b   Hardy, Gil ^c  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c MASSEY UNIVERSITY   (New Zealand)

Author keywords

Critically ill patients; Pharmacokinetics; Selenium; Systemic inflammatory response syndrome

Indexed keywords

GLUTATHIONE PEROXIDASE; SELENIO; SELENITE; SELENIUM; UNCLASSIFIED DRUG; SODIUM SELENITE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RESPONSE; ENZYME ACTIVITY; FEMALE; HUMAN; INTENSIVE CARE; KIDNEY INJURY; LIVER DYSFUNCTION; LOADING DRUG DOSE; MALE; OUTCOME ASSESSMENT; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; AGED; BLOOD; DOSE RESPONSE; MIDDLE AGED; PILOT STUDY; PROSPECTIVE STUDY; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AGED; CRITICAL ILLNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; SELENIUM; SODIUM SELENITE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77952740986     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.06.022     Document Type: Article

References (49)

1. Rayman M.P. The importance of selenium to human health. Lancet 2000, 356:233-241.
2. Hardy G., Hardy I. Selenium: the Se-XY nutraceutical. Nutrition 2004, 20:590-593.
3. Shenkin A. The key role of micronutrients. Clin Nutr 2006, 25:1-13.
4. Demling R.H., De Biasse M.A. Micronutrients in critical illness. Crit Care Clin 1995, 11:651-673.
5. Shenkin A., Allwood M.C. Trace elements and vitamins in adult intravenous nutrition. Clinical nutrition: parenteral nutrition 2001, 60-79. Saunders, Philadelphia. 3rd ed. J.L. Rombeau, R.H. Rolandelli (Eds.).
6. Gamble S.C. Selenium-dependent glutathione peroxidase and other selenoproteins: their synthesis and biochemical roles. J Chem Tech Biotechnol 1997, 68:123-134.
7. Papp L.V., Lu J., Holmgren A., Khanna K.K. From Selenium to Selenoproteins: synthesis, identify, and their role in human health. Antioxid Redox Signal 2007, 9:775-806.
8. Forceville X. Seleno-enzymes and seleno-compounds: the two faces of selenium. Crit Care 2006, 10:180.
9. Harrison I., Littlejohn D., Fell G.S. Distribution of selenium in human blood plasma and serum. Analyst 1996, 121:189-194.
10. Gao Y., Liu Y., Deng G., Wang Z. Distribution of selenium-containing proteins in human serum. Biol Trace Elem Res 2004, 100:105-115.
11. Manzanares W., Biestro A., Galusso F., Torre M.H., Mañay N., Pittini G., et al. Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill. Intensive Care Med 2009, 35:882-889.
12. Vincent J.L., Forceville X. Critically elucidating the role of selenium. Curr Opin Anesthesiol 2008, 21:148-154.
13. Forceville X., Van Antwerpen P. Selenocompounds and selenium: a biochemical approach to sepsis. 2008 Yearbook in intensive care and emergency medicine 2008, 454-466. Springer-Verlag, Berlin. J.L. Vincent (Ed.).
14. Kretz-Remy C., Patrick Arrigo A. Selenium: a key element that controls NF-κB activation and IκBα half-life. Biofactors 2001, 14:117-125.
15. Kim S.H., Johnson V.J., Shin T.Y., Sharma R.P. Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signalling pathways. Exp Biol Med (Maywood) 2004, 229:203-213.
16. Maehira F., Miyagi I., Eguchi Y. Selenium regulates transcription factor NF-kB activation during the acute phase reaction. Clin Chem Acta 2003, 334:163-171.
17. Jeong D.W., Yoo M.H., Kim T.S., Kim J.H., Kim I.Y. Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa B activation. J Biol Chem 2002, 277:17871-17876.
18. Forceville X., Vitoux D., Gauzit R., Combes A., Lahilaire P., Chappuis P. Selenium, systemic immune response syndrome, sepsis and outcome in critically ill patients. Crit Care Med 1998, 26:1536-1544.
19. Sakr Y., Reinhart K., Bloos F., Marx G., Russwurm S., Bauer M., Brunkhorst F. Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis and multiorgan failure. Br J Anaesth 2007, 98:775-784.
20. Geoghegan M., McAuley D., Eaton S., Powell-Tuck J. Selenium in critical illness. Curr Opin Crit Care 2006, 12:136-141.
21. Heyland D.K., Dhaliwal R., Suchner U., Berger M.M. Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 2005, 31:327-337.
22. Angstwurm M.W.A., Gaertner R. Practicalities of selenium supplementation in critically ill patients. Curr Opin Clin Nutr Metab Care 2006, 9:233-238.
23. Manzanares W. Selenium in critically ill patients with systemic inflammatory response. Nutr Hosp 2007, 22:295-306.
24. Angstwurm M.W.A., Engelmann L., Zimmermann T., Lenhmann C., Spes C.H., Abel P., et al. Selenium in Intensive Care (SIC) study. Results of a prospective, randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 2007, 35:118-126.
25. Wang Z., Forceville X., Van Antwerpen P., Piagnerelli M., Ahishakiye D., Macours P., et al. A large bolus, but not a continuous infusion, of sodium selenite improves outcome in peritonitis. Shock 2009, 32:140-146.
26. Quintiliani R., Quintiliani R. Pharmacokinetics/pharmacodynamics for critical care clinicians. Crit Care Clin 2008, 24:335-348.
27. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-873. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference.
28. Bernard G.R., Artigas A., Brigham K.L., Carlet J., Falke K., Hudson L., et al. The American-European consensus conference on ARDS. Definition, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
29. Manzanares W., Torre M.H., Biestro A., Galusso F., Facchín G., Hardy G. Pharmacokinetics and pharmacodynamics of high dose selenium in systemic inflammatory response syndrome. Clin Nutr 2008, 3(suppl 1):6-7.
30. Stewart M.S., Spallholz J.E., Neldner K.H., Pence B.C. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med 1999, 26:42-48.
31. Chung Y.W., Kim T.S., Lee S.Y., Lee S.H., Choi Y., Kim N., et al. Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway. Toxicol Lett 2006, 160:143-150.
32. Nilsonne G., Sun X., Nystrom C., Rundlöf A.K., Potamitou Fernandes A., Björnstedt M., Dobra K. Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells trough oxidative stress. Free Radic Biol Med 2006, 41:874-885.
33. Schrauzer G.N. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr 2000, 130:1653-1656.
34. Wernerman J. Role of glutamine supplementation in critically ill patients. Curr Opin Anaesthesiol 2008, 21:155-159.
35. Eaton S. The biochemical basis of antioxidant therapy in critical illness. Proc Nutr Soc 2006, 65:242-249.
36. Heyland D.K., Dhaliwal R., Day A.G., Muscedere J., Drover J., Suchner U., et al. Reducing Deaths due to Oxidative Stress (The REDOXS Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically ill patients. Proc Nutr Soc 2006, 65:250-263.
37. Heyland D.K., Dhaliwalm R.D., Day A., Drover J., Cote H., Wischmeyer P. Optimizing the dose of Glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. JPEN 2007, 31:109-118.
38. Hardy G., Hardy I.J., Powell-Tuck J. Compatibility of sodium selenite with L-alanyl L-glutamine dipeptide in normal saline admixtures. Clin Nutr 2008, 3(suppl 1):161-162.
39. Dhaliwal R., Drover J., Muscedere J., Heyland D.K. The REDOXS study: feasibility of pharmaconutrition in critically ill patients. Clin Nutr 2008, 3(suppl 1):41.
40. Andrews P.J., Avenell A., Noble D.W., Campbell M.K., Battison C.G., Croal B.L., et al. Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients. SIGNET (Scottish Intensive care Glutamine or seleNium Evaluative Trial). Trials 2007, 8:25.
41. Mishra V., Baines M., Perry S.E., McLaughlin P.J., Carson J., Wenstone R., Shenkin A. Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clin Nutr 2006, 26:41-50.
42. Forceville X., Laviolle B., Annane D., Vitoux D., Bleichner G., Korach J.M., et al. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double blind, phase II study. Crit Care 2007, 11:R73.
43. Olson O.E. Selenium toxicity in animals, with emphasis on man. J Am Coll Toxicol 1986, 5:45-69.
44. Forceville X., Chancerelle Y., Agay D., Galusso F., Facchín G., Hardy G., et al. At moderately high level, sodium selenium seems to decrease mortality in lipopolysaccharide rat model (abstract). Intensive Care Med 2004, 30:S110.
45. Berger M.M. Can oxidative damage be treated nutritionally?. Clin Nutr 2005, 24:172-183.
46. Berger M.M., Chioléro R.L. Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med 2007, 35(suppl):S584-S590.
47. Berger M.M., Shenkin A. Selenium in intensive care: probably not a magic bullet but an important adjuvant therapy. Crit Care Med 2007, 35:306-307.
48. Heyland D.K. Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?. Crit Care 2007, 11:153.
49. Manzanares W., Hardy G. Selenium supplementation in the critically ill: posology and pharmacokinetics. Curr Opin Clin Nutr Metab Care 2009, 12:273-280.