Successful treatment of disseminated intravascular coagulation in a child with acute myelogenous leukaemia using recombinant thrombomodulin

British Journal of Haematology

Volumn 149, Issue 6, 2010, Pages 911-912

  Ogawa, Erika ^a   Yagasaki, Hiroshi ^a   Kato, Maiko ^a   Shichino, Hiroyuki ^a   Chin, Motoaki ^a   Mugishima, Hideo ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Anticoagulant therapy; Disseminated intravascular coagulation; Recombinant thrombomodulin

Indexed keywords

CYTARABINE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; RECOMBINANT THROMBOMODULIN; RECOMODULIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ACUTE GRANULOCYTIC LEUKEMIA; BONE MARROW BIOPSY; CASE REPORT; CHILD; CLINICAL FEATURE; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE COURSE; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG MEGADOSE; FEMALE; GINGIVA BLEEDING; HUMAN; LABORATORY TEST; LETTER; PRIORITY JOURNAL; PURPURA; SCHOOL CHILD; TREATMENT RESPONSE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; RECOMBINANT PROTEINS; THROMBOMODULIN;

EID: 77952717240     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08135.x     Document Type: Letter

References (7)

1. Dhainaut, J.F., Yan, S.B., Joyce, D.E., Pettilä, V., Basson, B., Brandt, J.T., Sundin, D.P. Levi, M. (2004) Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. Journal of Thrombosis and Haemostasis, 2, 1924 1933.
2. Kienast, J., Juers, M., Wiedermann, C.J., Hoffmann, J.N., Ostermann, H., Strauss, R., Keinecke, H.O., Warren, B.L. Opal, S.M. (2006) Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. Journal of Thrombosis and Haemostasis, 4, 90 97.
3. Levi, M., Toh, C.H., Thachil, J. Watson, H.G. (2009) Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Journal of Haematology, 145, 24 33.
4. Maruyama, I. (1999) Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation. Thrombosis and Haemostasis, 82, 719 721.
5. Moll, S., Lindley, C., Pescatore, S., Morrison, D., Tsuruta, K., Mohri, M., Serada, M., Sata, M., Shimizu, H., Yamada, K. White, II., G.C. (2004) Phase I study of a novel recombinant human soluble thrombomodulin, ART-123. Journal of Thrombosis and Haemostasis, 2, 1745 1751.
6. Saito, H., Maruyama, I., Shimazaki, S., Yamamoto, Y., Aikawa, N., Ohno, R., Hirayama, A., Matsuda, T., Asakura, H., Nakashima, M. Aoki, N. (2007) Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. Journal of Thrombosis and Haemostasis, 5, 31 41.
7. Taylor, Jr., F.B., Toh, C.H., Hoots, W.K., Wada, H. Levi, M. (2001) Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thrombosis and Haemostasis, 86, 1327 1330.